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Ethnic-Specific In Vitro–In Vivo Extrapolation and Physiologically Based Pharmacokinetic Approaches to Predict Cytochrome P450-Mediated Pharmacokinetics in the Chinese Population: Opportunities and Challenges

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Acknowledgments

The authors wish to thank Dr Yunfei Li for his assistance with the preparation of this manuscript. This work was supported by the National Key Technology R&D Program Project of China (grant no. 2008BAI51B03), the National Key Project for IND of China (grant nos. 2012ZX09303-003, 2012ZX09303009-001) and the Leading Academic Discipline Project of the Shanghai Municipal Education Commission (grant nos. 085ZY1202, J50303, ZYSNXD-CC-LCPJ). The authors have no conflicts of interest that are directly relevant to the content of this study.

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Authors and Affiliations

  1. Center for Drug Clinical Research, Shanghai University of Chinese Medicine, No. 1200 Cailun Road, Shanghai, 201203, China

    Guo-Fu Li, Hong-Xia Liu & Qing-Shan Zheng

  2. Medical Research Center, Subei People’s Hospital & Clinical Medical School of Yangzhou University, Yangzhou, China

    Guo Yu

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  1. Guo-Fu Li
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  2. Guo Yu
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  3. Hong-Xia Liu
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  4. Qing-Shan Zheng
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Correspondence to Qing-Shan Zheng.

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Li, GF., Yu, G., Liu, HX. et al. Ethnic-Specific In Vitro–In Vivo Extrapolation and Physiologically Based Pharmacokinetic Approaches to Predict Cytochrome P450-Mediated Pharmacokinetics in the Chinese Population: Opportunities and Challenges. Clin Pharmacokinet 53, 197–202 (2014). https://doi.org/10.1007/s40262-013-0119-9

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