Clinical Drug Investigation

, Volume 35, Issue 10, pp 653–657 | Cite as

Association of Meloxicam Use with the Risk of Acute Pancreatitis: A Case–Control Study

  • Shih-Wei Lai
  • Cheng-Li Lin
  • Kuan-Fu LiaoEmail author
Original Research Article


Background and Objective

No sufficient research has focused on the relationship between meloxicam use and acute pancreatitis. This study aimed to explore this issue in Taiwan.


This case–control study was conducted using the database of the Taiwan National Health Insurance Program. In all, there were 6780 cases aged 20–84 years who were newly diagnosed with acute pancreatitis during the period 1998–2011, and 21,393 control subjects without acute pancreatitis. Cases and controls were matched for sex, age and comorbidities. Odds ratios (ORs) and 95 % confidence intervals (CIs) were measured to explore the associations between acute pancreatitis, meloxicam use and comorbidities, using a multivariable unconditional logistic regression model.


After controlling for potential confounding factors, the adjusted OR for acute pancreatitis was 1.76 (95 % CI 1.30–2.40) for subjects with current use of meloxicam, in comparison with subjects who had never used meloxicam. The adjusted OR decreased to 1.29 (95 % CI 0.82–2.03) for subjects with late use of meloxicam, but without statistical significance.


Current use of meloxicam is associated with increased odds of acute pancreatitis. Clinicians should consider the potential risk of acute pancreatitis when prescribing meloxicam.


Chronic Obstructive Pulmonary Disease Chronic Kidney Disease Acute Pancreatitis Meloxicam Biliary Stone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Specific Author Contributions

Shih-Wei Lai substantially contributed to the conception of the article. He planned and conducted this study, initiated the draft of the article and critically revised the article.

Cheng-Li Lin conducted the data analysis and critically revised the article.

Kuan-Fu Liao planned and conducted this study, participated in the data interpretation and critically revised the article.

Compliance with Ethical Standards


This study was supported in part by the Taiwan Ministry of Health and the Welfare Clinical Trial and Research Center of Excellence (Grant No. MOHW104-TDU-B-212-113002), China Medical University Hospital, Academia Sinica Taiwan Biobank, Stroke Biosignature Project (Grant No. BM104010092), NRPB Stroke Clinical Trial Consortium (Grant No. MOST 103-2325-B-039-006), Tseng-Lien Lin Foundation, Taichung, Taiwan, Taiwan Brain Disease Foundation, Taipei, Taiwan, and Katsuzo and Kiyo Aoshima Memorial Funds in Japan. These funding agencies did not influence the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Conflict of interest statement

The authors disclose no conflicts of interest.


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.College of MedicineChina Medical UniversityTaichung CityTaiwan
  2. 2.Department of Family MedicineChina Medical University HospitalTaichung CityTaiwan
  3. 3.Management Office for Health DataChina Medical University HospitalTaichung CityTaiwan
  4. 4.College of MedicineTzu Chi UniversityHualien CityTaiwan
  5. 5.Department of Internal MedicineTaichung Tzu Chi General HospitalTaichung CityTaiwan
  6. 6.Graduate Institute of Integrated MedicineChina Medical UniversityTaichung CityTaiwan

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