Clinical Drug Investigation

, Volume 33, Issue 11, pp 789–794 | Cite as

Pharmaceutical Costs of Assisted Reproduction in Spain

  • Maria-Reyes LorenteEmail author
  • Juana Hernández
  • Fernando Antoñanzas
Original Research Article



Assisted reproduction is one of the health services currently being considered for possible limitation or exclusion from the public health services portfolio in Spain. One of the main reasons claimed for this is the impact on the budget for pharmaceutical expenditure.


The objective of this study was to assess the significance of the pharmaceutical costs of assisted reproduction in Spain.


This study focused on medical practice in Spain, and is based on the opinions of experts in assisted reproduction and the results provided by professional societies’ publications. The reference year is 2012 and the setting was secondary care. We have included all existing pharmaceutical modalities for assisted reproduction, as well as the most common drug for each modality. We have considered the pharmaceutical cost per cycle for artificial insemination, in vitro fertilisation with or without intracytoplasmic sperm injection (IVF_ICSI), and cryotransfer and donated fresh oocytes reception.


In Spain, artificial insemination has a pharmaceutical cost per cycle of between €69.36 and €873.79. This amounts to an average cycle cost of €364.87 for partner’s sperm and €327.10 for donor sperm. The pharmaceutical cost of IVF_ICSI ranges between €278.16 and €1,902.66, giving an average cost per cycle of €1,139.65. In the case of cryotransfer and donated fresh oocytes reception, the pharmaceutical cost per cycle is between €22.61 and €58.73, yielding an average cost of €40.67. The budgetary impact of pharmaceutical expenditure for assisted reproduction in Spain for the year 2012 was estimated at €98.7 million.


In Spain, the total pharmaceutical cost of assisted reproduction is substantial. According to our results, we can say that about 29 % of the total pharmaceutical expenditure for assisted reproduction techniques is funded by the National Health System and the rest represents 2.4 % of the total annual out-of-pocket family expenditure on drugs.


Average Cost Ovarian Stimulation Artificial Insemination Assisted Reproduction Budgetary Impact 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



No sources of funding were used to assist in the preparation of this study. The authors have no potential conflicts of interest that are directly relevant to the content of this study.

Supplementary material

40261_2013_123_MOESM1_ESM.doc (33 kb)
Supplementary material 1 (DOC 33 kb)


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Copyright information

© Springer International Publishing Switzerland 2013

Authors and Affiliations

  • Maria-Reyes Lorente
    • 1
    Email author
  • Juana Hernández
    • 2
  • Fernando Antoñanzas
    • 1
  1. 1.University of La RiojaLogroñoSpain
  2. 2.Juana Hernández Gynecology ClinicLogroñoSpain

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