Skip to main content
Log in

Early Fungal Infection in an Aortic Prosthesis with Probable Cerebral Metastasis: The Success of a Conservative Strategy

  • Case Report
  • Published:
Clinical Drug Investigation Aims and scope Submit manuscript

Abstract

Infection of an aortic prosthesis presents a diagnostic and therapeutic challenge. Fungal infections are rarely described and among these Candida spp. are the most prevalent agents. Although the therapeutic approach to prosthetic bacterial infection may be conservative, in the case of fungal etiology, surgery, such as the removal and substitution of the device, debridement and repair of the infected prosthesis is usually warranted. The authors describe the case of a 48-year-old man, with a thoraco-abdominal aneurysm of the aorta, submitted to surgery for insertion of a prosthetic aortic duct. The procedure was made difficult by Candida albicans empyema associated with an aortic prosthesis infection that was complicated by probable cerebral metastasis. Antifungal therapy was the initial option, as the steady clinical, laboratory and radiological improvement deferred a surgical intervention. This case demonstrates the success of a conservative approach in a very serious fungal infection of a thoraco-abdominal aorta prosthesis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Kitamura T, Morota T, Motomura N, et al. Management of infected grafts and aneurysms of the aorta. Ann Vasc Surg. 2005;19:335–42.

    Article  PubMed  Google Scholar 

  2. Mathes DW, Yaremchuk MJ, Isselbacher EM, Madsen JC. Successful in situ treatment of an infected ascending aortic graft. Ann Thorac Surg. 2000;70:1410–2.

    Article  PubMed  CAS  Google Scholar 

  3. Bakoyiannis CN, Georgopoulos SE, Tsekouras NS, Klonaris CN, Papalambros EL, Bastounis EA. Fungal infection of aortoiliac endograft: a case report and review of the literature. Ann Vasc Surg. 2007;21:228–31.

    Article  PubMed  Google Scholar 

  4. Collazos J, Mayo J, Martínez E, Ibarra S. Prosthetic vascular graft infection due to Aspergillus species: case report and literature review. Eur J Clin Microbiol Infect Dis. 2001;20:414–7.

    PubMed  CAS  Google Scholar 

  5. Pappas PG, Kauffman C, Andes D, et al. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Disease Society of America. Clin Infect Dis. 2009;48:503–35.

    Article  PubMed  CAS  Google Scholar 

  6. Coselli JS, Koksoy C, LeMaire SA. Management of thoracic aortic graft infections. Ann Thorac Surg. 1996;67:1990–3.

    Article  Google Scholar 

  7. Antidulafungin prescribing information; Pfizer Inc NY. 2006. http://www.pfizer.com/pfizer/download/uspi_eraxis.pdf. Accessed June 22 2012.

  8. Kethireddy S, Andes D. CNS pharmacokinetics of antifungal agents. Expert Opin Drug Metab Toxicol. 2007;3:573–81.

    Article  PubMed  CAS  Google Scholar 

Download references

Disclosures

This manuscript has been published in a journal supplement that was created with an unrestricted educational grant from Gilead Portugal. The authors have no conflicts of interest to declare.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Anabela Malho Guedes.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Guedes, A.M., de Macedo, T.A., Rocha, C. et al. Early Fungal Infection in an Aortic Prosthesis with Probable Cerebral Metastasis: The Success of a Conservative Strategy. Clin Drug Investig 33 (Suppl 1), 41–45 (2013). https://doi.org/10.1007/s40261-012-0020-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40261-012-0020-6

Keywords

Navigation