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French Value-Set of the QLU-C10D, a Cancer-Specific Utility Measure Derived from the QLQ-C30

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Abstract

Background and objective

The EORTC Quality of Life Utility Measure-Core 10 Dimensions (QLU-C10D) is a new multi-attribute utility instrument derived from the EORTC Quality of Life Questionnaire-Core 30 (QLQ-C30), a widely used cancer-specific quality-of-life questionnaire. It covers ten dimensions: physical, role functioning, social, emotional functioning, pain, fatigue, sleep, appetite, nausea and bowel problems. To allow national health preferences to be reflected, country-specific valuations are being performed through collaboration between the Multi-Attribute Utility Cancer (MAUCa) Consortium and the EORTC. The aim of this study was to determine the utility weights for health states in the French version of the QLU-C10D.

Methods

Valuations were run in a web-based setting in a general population sample of 1033 adults. Utilities were elicited using a discrete-choice experiment (DCE). Data were analyzed by conditional logistic regression and mixed logits.

Results

The sample was representative of the general French population in terms of gender and age. Dimensions with the largest impact on utility weights were, in this order: physical functioning, pain and emotional functioning. The impact on utilities was lower for role functioning, nausea, bowel problems and social functioning. The dimensions of sleep, fatigue and lacking appetite were associated with the smallest utility decrement.

Conclusion

The results of the present study provide utility weights for the QLU-C10D and offer interesting prospects, as some cancer-specific dimensions also received sizeable utility weights (nausea and bowel problems). In fact, the EQ-5D and the HUI 3 are recommended in France and commonly used for cancer-related CUA; however, both these instruments are generic. The availability of a new cancer-specific utility instrument, such as the QLU-C10D, could improve the quality and the pertinence of future CUA in oncology

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Data Availability Statement

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Author information

Authors and Affiliations

  1. Department of Pharmacy, University Hospital, Boulevard Fleming, 25030, Besancon Cedex, France

    Virginie Nerich

  2. INSERM, EFS-BFC, UMR1098, University of Franche-Comté, Besançon, France

    Virginie Nerich

  3. Division of Psychiatry II, Department of Psychiatry, Psychotherapy and Psychosomatics, Medical University of Innsbruck, Innsbruck, Austria

    Eva Maria Gamper & Bernhard Holzner

  4. School of Public Health, Curtin University, Perth, WA, Australia

    Richard Norman

  5. School of Psychology, Faculty of Science, University of Sydney, Sydney, NSW, Australia

    Madeleine King

  6. Sydney Medical School, Faculty of Medicine, University of Sydney, Sydney, NSW, Australia

    Madeleine King

  7. Centre for for Health Economics Research and Evaluation (CHERE), UTS Business School University of Technology Sydney (UTS), Sydney, NSW, Australia

    Rosalie Viney

  8. Division of Psychiatry I, Department of Psychiatry, Psychotherapy and Psychosomatics, Medical University of Innsbruck, Innsbruck, Austria

    Georg Kemmler

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  1. Virginie Nerich
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  2. Eva Maria Gamper
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  4. Madeleine King
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  6. Rosalie Viney
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  7. Georg Kemmler
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Prof. VN and GK. The first draft of the manuscript was written by Prof. VN and Dr GK and all co-authors commented on previous versions of the manuscript. All authors approved the final manuscript.

Corresponding author

Correspondence to Virginie Nerich.

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Funding

This research project was funded by Grant Number 002-2014 of the EORTC Quality of Life Group. Professor King was supported by the Australian Government through Cancer Australia.

Conflict of interest

The authors declare no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Medical University of Innsbruck Ethics Committee, number 20151207–1336.

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Nerich, V., Gamper, E.M., Norman, R. et al. French Value-Set of the QLU-C10D, a Cancer-Specific Utility Measure Derived from the QLQ-C30. Appl Health Econ Health Policy 19, 191–202 (2021). https://doi.org/10.1007/s40258-020-00598-1

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  • DOI: https://doi.org/10.1007/s40258-020-00598-1

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