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Table 3 Clinical outcome comparisons (study references in square brackets)

From: The Impact of Generic Substitution on Health and Economic Outcomes: A Systematic Review

Clinical outcomes De novo patients starting on generics Maintenance patients switching to generics Both: de novo and maintenance patients Total n = 37
n = 14 studies n = 21 studies n = 2 studies
Evidence supporting generic use Evidence opposing generic use Evidence supporting generic use Evidence opposing generic use Evidence supporting generic use Evidence opposing generic use
Dose adjustments 3 7 7 17
[23, 25, 52] [20, 21, 26, 29, 49, 50, 54] [22, 30, 35, 37, 47, 48, 58]
Concomitant medication 3 3 4 1 11
[32, 34, 55] [21, 26, 37] [22, 31, 47, 56] [42]
Adherence 1 3 3 1 8
[57] [34, 53, 55] [39, 45, 46] [43]
Adverse events 8 3 11 3 1 26
[2325, 32, 40, 51, 52, 59] [33, 38, 53] [20, 21,29, 36, 39, 45, 4850, 54, 58] [27, 28, 41] [43]
Healthcare utilization 4 5 2 1 12
[23, 34, 38, 57] [20, 21, 3537] [31, 47] [42]
Surrogate endpoints 6 2 9 5 22
[24, 25, 32, 40, 52, 59] [51, 53] [20, 29, 36, 39, 45, 48, 49, 54, 58] [26, 27, 35, 41, 50]
Others 1 1
[43]
Overall equivalence 25 8 38 21 2 3 97