Skip to main content
SpringerLink
Log in

Comment on: “Methotrexate Cutaneous Ulceration: A Systematic Review of Cases”

  • Letter to the Editor
  • Published:
American Journal of Clinical Dermatology Aims and scope Submit manuscript

A Letter to the Editor to this article was published on 17 April 2023

The Original Article was published on 29 April 2022

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Data availability statement

The data that supports the findings of this study are available within the material of this article and the supplementary material.

References

  1. Berna R, Rosenbach M, Margolis DJ, Mitra N, Baumrin E. Methotrexate cutaneous ulceration: a systematic review of cases. Am J Clin Dermatol. 2022;23(4):449–57. https://doi.org/10.1007/s40257-022-00692-1.

    Article  PubMed  Google Scholar 

  2. Bedoui Y, Guillot X, Sélambarom J, Guiraud P, Giry C, Jaffar-Bandjee MC, et al. Methotrexate an old drug with new tricks. Int J Mol Sci. 2019;20(20):5023. https://doi.org/10.3390/ijms20205023.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Weinstein GD, Frost P. Methotrexate for psoriasis: a new therapeutic schedule. Arch Dermatol. 1971;103(1):33–8. https://doi.org/10.1001/archderm.1971.04000130035004.

    Article  CAS  PubMed  Google Scholar 

  4. Gyulai R, Bagot M, Griffiths CEM, Luger T, Naldi L, Paul C, et al. Current practice of methotrexate use for psoriasis: results of a worldwide survey among dermatologists. J Eur Acad Dermatol Venereol. 2015;29(2):224–31. https://doi.org/10.1111/jdv.12495.

    Article  CAS  PubMed  Google Scholar 

  5. Arnet I, Bernhardt V, Hersberger KE. Methotrexate intoxication: the pharmaceutical care process reveals a critical error. J Clin Pharm Ther. 2012;37(2):242–4. https://doi.org/10.1111/j.1365-2710.2011.01263.x.

    Article  CAS  PubMed  Google Scholar 

  6. Pradhan S, Sirka CS, Rout AN, Dash G, Sahu K. Acute methotrexate toxicity due to overdosing in psoriasis: a series of seven cases. Indian Dermatol Online J. 2019;10(1):64–8. https://doi.org/10.4103/idoj.IDOJ_157_18.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Vial T, Patat AM, Boels D, Castellan D, Villa A, Theophile H, Torrents R, et al. Adverse consequences of low-dose methotrexate medication errors: data from French poison control and pharmacovigilance centers. Jt Bone Spine. 2019;86(3):351–5. https://doi.org/10.1016/j.jbspin.2018.09.006.

    Article  CAS  Google Scholar 

  8. Cairns R, Brown JA, Lynch AM, Robinson J, Wylie C, Buckley NA. A decade of Australian methotrexate dosing errors. Med J Aust. 2016;204(10):384. https://doi.org/10.5694/mja15.01242.

    Article  PubMed  Google Scholar 

  9. Radmanesh M, Rafiei B, Moosavi ZB, Sina N. Weekly vs. daily administration of oral methotrexate (MTX) for generalized plaque psoriasis: a randomized controlled clinical trial. Int J Dermatol. 2011;50(10):1291–3. https://doi.org/10.1111/j.1365-4632.2011.04967.

    Article  CAS  PubMed  Google Scholar 

  10. Chen M, Suzuki A, Thakkar S, Yu K, Hu C, Tong W. DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug Discov Today. 2016;21(4):648–53. https://doi.org/10.1016/j.drudis.2016.02.015.

    Article  CAS  PubMed  Google Scholar 

  11. Pharmacovigilance Risk Assessment Committee. PRAC recommends new measures to avoid dosing errors with methotrexate. European Medicines Agency. 2019. https://www.ema.europa.eu/en/news/prac-recommends-new-measures-avoid-dosing-errors-methotrexate. Accessed 5 Jan 2023.

  12. Conn VS, Ruppar TM, Chan KC, Dunbar-Jacob J, Pepper GA, De Geest S. Packaging interventions to increase medication adherence: systematic review and meta-analysis. Curr Med Res Opin. 2015;31(1):145–60. https://doi.org/10.1185/03007995.2014.978939.

    Article  PubMed  Google Scholar 

  13. Institute for Safe Medication Practices. Call to action: longstanding strategies to prevent accidental daily methotrexate dosing must be implemented. Institute for Safe Medication Practices; 2018. https://www.ismp.org/resources/call-action-longstanding-strategies-prevent-accidental-daily-methotrexate-dosing-must-be. Accessed 10 Jan 2023.

Download references

Author information

Authors and Affiliations

  1. College of Medicine, McGovern Medical School at UTHealth Houston, Houston, TX, USA

    Aarthi Parvathaneni

  2. Ascension Medical Group Dermatology, Austin, TX, USA

    Adam Olesen

  3. Division of Dermatology, Department of Internal Medicine, Dell Medical School, Austin, TX, USA

    Dayna Diven

Authors
  1. Aarthi Parvathaneni
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Adam Olesen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dayna Diven
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Dayna Diven: conceptualized the project and provided edits. Adam Olesen: edited the paper, gave suggestions for references, and reformatted the paper. Aarthi Parvathaneni: Primary writter of the paper.

Corresponding author

Correspondence to Aarthi Parvathaneni.

Ethics declarations

Funding

No sources of funding were used to assist in the preparation of this article.

Conflicts of interest

Aarthi Parvathaneni, Adam Olesen, and Danya Diven have no conflicts of interest to declare.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Parvathaneni, A., Olesen, A. & Diven, D. Comment on: “Methotrexate Cutaneous Ulceration: A Systematic Review of Cases”. Am J Clin Dermatol 24, 487–489 (2023). https://doi.org/10.1007/s40257-023-00773-9

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40257-023-00773-9

Search

Navigation