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Neutrophilic Dermatoses Associated with Myeloid Malignancies

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Abstract

Neutrophilic dermatoses (ND) are a group of conditions characterized by an aseptic accumulation of polymorphonuclear leukocytes in the skin. Occurrence of ND in association with myeloid malignancies, mainly myelodysplastic syndrome and myelogenous acute leukemia, is not rare and is often associated with a poor prognosis. Recent findings have improved understanding of the pathophysiology of myeloid malignancy-associated ND. We review the clinical spectrum of myeloid malignancy-associated ND with an emphasis on recently identified mechanisms. Myeloid leukemia cells retain the potential for terminal differentiation into polymorphonuclear leukocytes in the skin. Many studies suggest a clonal link between myeloid malignancies and ND. Activation of autoinflammatory pathways (NOD-like receptor family pyrin domain-containing-3, Familial Mediterranean Fever Gene) in the clonal cells of myeloid disorders may also be involved in this setting.

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  1. Assistance Publique-Hôpitaux de Paris, Département de Dermatologie, Hôpital Saint-Louis, 1, Avenue Claude Vellefaux, 75010, Paris, France

    Clémence Lepelletier, Jean-David Bouaziz, Michel Rybojad & Martine Bagot

  2. Université Paris-Diderot, Sorbonne Paris Cité, Paris, France

    Clémence Lepelletier, Jean-David Bouaziz & Martine Bagot

  3. Assistance Publique-Hôpitaux de Paris, Service de Médecine interne, Hôpital Tenon, Paris, France

    Sophie Georgin-Lavialle

  4. Université Pierre et Marie Curie, Sorbonne Paris Cité, Paris, France

    Sophie Georgin-Lavialle

  5. Assistance Publique-Hôpitaux de Paris, Département de Pathologie, Hôpital Saint-Louis, Paris, France

    Marie-Dominique Vignon-Pennamen

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  1. Clémence Lepelletier
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  2. Jean-David Bouaziz
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Correspondence to Clémence Lepelletier.

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CL, J-DB, MR MB, SG-L, and M-DV-P have no conflicts of interest that are directly relevant to the content of this article.

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Lepelletier, C., Bouaziz, JD., Rybojad, M. et al. Neutrophilic Dermatoses Associated with Myeloid Malignancies. Am J Clin Dermatol 20, 325–333 (2019). https://doi.org/10.1007/s40257-018-00418-2

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