Biological Therapy of Refractory Ulcerative Oral Lichen Planus with Plasma Rich in Growth Factors
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Oral lichen planus (OLP) is a chronic inflammatory disorder affecting stratified squamous epithelia and oral mucosa [1, 2]. The atrophic-erosive form has symptoms that range from a mild burning sensation to severe pain, affecting the patient’s quality of life .
The treatment of choice for OLP is topical corticosteroids [4, 5]. In the event of acute exacerbation and refractory lesions, systemic corticosteroids are often prescribed. However, corticosteroid treatment is not always effective and several treatment modalities have been suggested.
In this study, we present an alternative treatment for patients with OLP who are refractory to corticosteroid therapy. This treatment is based on the infiltration of autologous plasma rich in growth factors (PRGF) into ulcerative and erosive lesions of OLP.
Materials and Methods
Patients with ulcerative-erosive OLP, diagnosed by clinical histopathological examination, and refractory to corticosteroids therapy were included in the...
KeywordsHepatocyte Growth Factor Mycophenolate Mofetil Pemphigus Lichen Planus Triamcinolone Acetonide
Compliance with Ethical Standards
No funding was received for the conduct of this study.
Conflict of interest
Eduardo Anitua is the Scientific Director of BTI Biotechnology Institute (Vitoria, Spain) and the head of the Foundation Eduardo Anitua, Vitoria, Spain. Laura Piñas and Ricardo Suarez Fernández have no conflicts of interest directly relevant to the content of this article. Mohammad Hamdan Alkhraisat is a scientist at BTI Biotechnology Institute (Vitoria, Spain).
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