American Journal of Clinical Dermatology

, Volume 18, Issue 2, pp 287–297

The Inpatient Burden of Autoimmune Blistering Disease in US Children: Analysis of Nationwide Inpatient Sample Data

  • Ziyou Ren
  • Derek Y. Hsu
  • Nanette B. Silverberg
  • Jonathan I. Silverberg
Original Research Article

DOI: 10.1007/s40257-017-0257-1

Cite this article as:
Ren, Z., Hsu, D.Y., Silverberg, N.B. et al. Am J Clin Dermatol (2017) 18: 287. doi:10.1007/s40257-017-0257-1



Little is known about the epidemiology of pediatric autoimmune blistering disorders (PAIBD).


We sought to determine the inpatient burden and comorbidities of PAIBD.


We analyzed data from the Nationwide Inpatient Sample from 2002 to 2012, which contained a representative 20% sample of all US hospitalizations.


The most common PAIBD with a primary admission was pemphigus (8.0 per million), whereas the most common secondary diagnosis of PAIBD was dermatitis herpetiformis (DH; 9.6 per million). Bullous pemphigoid (BP) was inversely associated with being female and having government or no insurance but positively associated with Black and Hispanic race/ethnicity and more chronic conditions. Pemphigus was associated with being female, Hispanic, having government or no insurance, and having a higher number of chronic conditions. DH was inversely associated with non-White race but positively associated with having government insurance and more chronic conditions. BP was associated with dialysis, hypertension, and diabetes. Pemphigus was associated with osteoarthritis, renal failure, hypothyroidism, and weight loss. DH was associated with herpes simplex virus infection, rheumatoid arthritis, and fungal, viral, and other skin infections.


PAIBD are associated with a considerable inpatient burden and comorbid health conditions.

Supplementary material

40257_2017_257_MOESM1_ESM.pdf (47 kb)
Supplementary material 1 (PDF 47 kb)

Funding information

Funder NameGrant NumberFunding Note
Agency for Healthcare Research and Quality (US)
    Dermatology Foundation (US)

      Copyright information

      © Springer International Publishing Switzerland 2017

      Authors and Affiliations

      • Ziyou Ren
        • 1
        • 2
      • Derek Y. Hsu
        • 1
      • Nanette B. Silverberg
        • 3
      • Jonathan I. Silverberg
        • 4
      1. 1.Department of DermatologyNorthwestern University Feinberg School of MedicineChicagoUSA
      2. 2.The Graduate SchoolNorthwestern UniversityChicagoUSA
      3. 3.Department of DermatologyMount-Sinai Icahn School of MedicineNew YorkUSA
      4. 4.Departments of Dermatology, Preventive Medicine and Medical Social SciencesNorthwestern University Feinberg School of MedicineChicagoUSA

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