Platelet-rich plasma (PRP) is a solution derived from whole blood that is enriched in the platelet fraction. Platelets serve as a reservoir of growth factors and cytokines. When platelets are activated in vivo, signaling molecules are released into the immediate microenvironment and activate receptors for various pathways. Historically, PRP has been applied to wound beds to promote healing of complex wounds. Over the last decade, it has served as a valuable therapeutic tool in various specialties such as maxillofacial surgery, plastic surgery, orthopedics and sports medicine. Only recently has PRP been utilized for dermatologic purposes, more specifically, for the treatment of male and female pattern hair loss. In this review, we discuss molecular and cellular pathways upregulated by PRP important in hair folliculogenesis, and examine clinical evidence from all previously published studies involving the use of PRP for pattern hair loss.
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The authors would like to thank Nicole Rogers, MD, FAAD, FISHRS for providing the sample protocol and the clinical photographs.
No funding was received for the preparation of this review.
Conflict of interest
Babu Singh and Lynne J. Goldberg have no conflicts of interest to declare.
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Singh, B., Goldberg, L.J. Autologous Platelet-Rich Plasma for the Treatment of Pattern Hair Loss. Am J Clin Dermatol 17, 359–367 (2016). https://doi.org/10.1007/s40257-016-0196-2
- Hair Follicle
- Hair Loss
- Pyoderma Gangrenosum
- Dermal Papilla