Coffee Consumption and Melanoma: A Systematic Review and Meta-Analysis of Observational Studies
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Laboratory and animals studies have suggested a possible protective effect of coffee consumption on the development of melanoma. However, the results of epidemiological studies investigating this association have been inconclusive.
A systematic review and meta-analysis of published studies was conducted to evaluate any association between coffee consumption and melanoma.
Observational studies were searched for in MEDLINE, EMBASE, and the Cochrane Central Register from inception to September 1, 2015. The Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guidelines were followed in conducting this study.
We identified nine observational studies with a total of 927,173 study participants, of which 3787 had melanoma. With random-effects modeling, the pooled relative risks (RR) for melanoma among regular coffee drinkers was 0.75 (95 % confidence interval [CI] 0.63–0.89, p = 0.001) compared with controls. Visual inspection of a funnel plot suggested publication bias, although Egger’s test (p = 0.981) delineated no small-study effects. The pooled relative risks for melanoma among decaffeinated coffee drinkers was, however, not statistically significant at 0.92 (95 % CI 0.82–1.05, p = 0.215).
There is some evidence for the beneficial effects of regular coffee consumption on melanoma. More prospective cohort studies with systematic quantification of coffee consumption would be necessary to further elucidate this association.
KeywordsMelanoma Coffee Consumption Cochrane Central Register Relative Risk Estimate Pool Relative Risk
Compliance with Ethical Standards
No funding was received for the preparation of this review.
Conflict of interest
Yik Weng Yew, Yi Chun Lai and Robert A. Schwartz have no conflicts of interest.
- 1.American Cancer Society. What are the key statistics about melanoma skin cancer? 2014. Available at: http://www.cancer.org/cancer/skincancer-melanoma/detailedguide/melanoma-skin-cancer-key-statistics. Last accessed 1 April 2015.
- 2.Surveillance, Epidemiology, and End Results Program. SEER Stat Fact Sheets: melanoma of the skin. 2015. Available at: http://seer.cancer.gov/statfacts/html/melan.html. Last accessed 2 April 2015.
- 5.Heffernan TP, Kawasumi M, Blasina A, Anderes K, Conney AH, Nghiem P. ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine. J Invest Dermatol. 2009;129:1805–15.CrossRefPubMedPubMedCentralGoogle Scholar
- 24.Wu H, Reeves KW, Qian J, Sturgeon SR. Coffee, tea, and melanoma risk among postmenopausal women. Eur J Cancer Prev. 2014. doi: 10.1097/CEJ.0000000000000093.
- 25.Loftfield E, Freedman ND, Graubard BI, et al. Coffee drinking and cutaneous melanoma risk in the NIH-AARP diet and health study J Natl Cancer Inst. 2015;107. doi: 10.1093/jnci/dju421.
- 30.Cárdenas C, Quesada AR, Medina MA. Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene. McCormick DL, editor. PLoS One. 2011;6(8):e23407. doi: 10.1371/journal.pone.0023407.
- 38.Merritt MA, Tzoulaki I, Tworoger SS, De Vivo I, Hankinson SE, et al. Investigation of dietary factors and endometrial cancer risk using a nutrient-wide association study approach in the EPIC and Nurses’ Health Study (NHS) and NHSII. Cancer Epidemiol Biomarkers Prev. 2015;24:466–71.CrossRefPubMedPubMedCentralGoogle Scholar
- 45.Willett W. Nutritional epidemiology. 1st ed. New York: Oxford University Press; 1990.Google Scholar