American Journal of Clinical Dermatology

, Volume 17, Issue 2, pp 113–123 | Cite as

Coffee Consumption and Melanoma: A Systematic Review and Meta-Analysis of Observational Studies

  • Yik Weng YewEmail author
  • Yi Chun Lai
  • Robert A. Schwartz
Systematic Review



Laboratory and animals studies have suggested a possible protective effect of coffee consumption on the development of melanoma. However, the results of epidemiological studies investigating this association have been inconclusive.


A systematic review and meta-analysis of published studies was conducted to evaluate any association between coffee consumption and melanoma.


Observational studies were searched for in MEDLINE, EMBASE, and the Cochrane Central Register from inception to September 1, 2015. The Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guidelines were followed in conducting this study.


We identified nine observational studies with a total of 927,173 study participants, of which 3787 had melanoma. With random-effects modeling, the pooled relative risks (RR) for melanoma among regular coffee drinkers was 0.75 (95 % confidence interval [CI] 0.63–0.89, p = 0.001) compared with controls. Visual inspection of a funnel plot suggested publication bias, although Egger’s test (p = 0.981) delineated no small-study effects. The pooled relative risks for melanoma among decaffeinated coffee drinkers was, however, not statistically significant at 0.92 (95 % CI 0.82–1.05, p = 0.215).


There is some evidence for the beneficial effects of regular coffee consumption on melanoma. More prospective cohort studies with systematic quantification of coffee consumption would be necessary to further elucidate this association.


Melanoma Coffee Consumption Cochrane Central Register Relative Risk Estimate Pool Relative Risk 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Compliance with Ethical Standards


No funding was received for the preparation of this review.

Conflict of interest

Yik Weng Yew, Yi Chun Lai and Robert A. Schwartz have no conflicts of interest.


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Yik Weng Yew
    • 1
    • 2
    Email author
  • Yi Chun Lai
    • 2
    • 3
  • Robert A. Schwartz
    • 4
  1. 1.National Skin CentreSingaporeSingapore
  2. 2.Harvard T.H. Chan School of Public HealthBostonUSA
  3. 3.Rutgers New Jersey Medical SchoolNewarkUSA
  4. 4.Dermatology, Preventive Medicine, and PathologyRutgers New Jersey Medical School, and Rutgers University School of Public Affairs and AdministrationNewarkUSA

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