American Journal of Clinical Dermatology

, Volume 15, Issue 2, pp 101–113 | Cite as

Perioral Dermatitis: A Review of the Condition with Special Attention to Treatment Options

  • Therdpong TemparkEmail author
  • Tor A. Shwayder
Review Article


Perioral dermatitis is a common acneiform facial eruption found in both adults and children. Its variants are periorificial and granulomatous periorificial dermatitis. The etiology of perioral dermatitis remains unknown; however, topical corticosteroid use on the face commonly precedes the manifestation of this condition. There are an overwhelming number of treatment options for perioral dermatitis, and the options in children are slightly different from those in adults for both systemic medications and topical treatment. This article provides a literature review of the various applicable treatments available based on the level and quality of the evidence by the US Preventive Service Task Force. Oral tetracycline reveals the best valid evidence. However, if the patient is less than 8 years old, then this oral therapy may not be suitable. Topical metronidazole, erythromycin, and pimecrolimus also represent effective treatment choices with good evidence. Topical corticosteroid use is common in these cases and the question of whether it is a good treatment or a cause remains unanswered. Corticosteroid cream can improve the clinical picture, but there is a risk of rebound when treatment is stopped. We propose a treatment algorithm to assist dermatologists, pediatric dermatologists, and general practitioners encountering this condition.


Isotretinoin Topical Corticosteroid Pimecrolimus Rosacea Seborrheic Dermatitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Statement of Funding


Conflict of Interest Disclosures

Dr. Tor A. Shwayder: None.

Dr. Therdpong Tempark: None.


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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  1. 1.Department of Pediatrics, Faculty of MedicineChulalongkorn UniversityBangkokThailand
  2. 2.Department of DermatologyHenry Ford HospitalDetroitUSA

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