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How May Proton Pump Inhibitors Impair Cardiovascular Health?

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Abstract

Proton pump inhibitors (PPIs) are among the most widely used drugs worldwide. They are used to treat a number of gastroesophageal disorders and are usually prescribed as a long-term medication or even taken without a prescription. There are a number of clinical studies that associate PPI use with an increased cardiovascular risk. In this article, we review the clinical evidence for adverse cardiovascular effects of PPIs, and we discuss possible biological mechanisms by which PPIs can impair cardiovascular health.

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  1. Department of Cardiovascular Sciences, Houston Methodist Research Institute, 6670 Bertner Ave, Houston, TX, 77030, USA

    Roman A. Sukhovershin & John P. Cooke

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  1. Roman A. Sukhovershin
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  2. John P. Cooke
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Correspondence to John P. Cooke.

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Funding

This study was funded in part by a Grant to Dr. Cooke from the National Institutes of Health (U01 HL100397).

Conflict of interest

Stanford University holds patents on therapeutic modulation of the nitric oxide synthase pathway, and on therapeutic uses of proton pump inhibitors, on which Dr. Cooke is an inventor. Dr. Sukhovershin declares that he has no conflict of interest.

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Sukhovershin, R.A., Cooke, J.P. How May Proton Pump Inhibitors Impair Cardiovascular Health?. Am J Cardiovasc Drugs 16, 153–161 (2016). https://doi.org/10.1007/s40256-016-0160-9

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