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Elaborate Design of Two Novel Fluorescent Zinc-based Metal-Organic Frameworks for Highly Efficient Tetracycline Antibiotics Detection

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Abstract

The abuse of tetracycline antibiotics has caused great harm to human health and ecosystems. Developing inexpensive, convenient and sensitive methods for the detection of tetracycline antibiotics is highly desirable. Herein, based on the H4ddp ligand [H4ddp=3-(3,5-dicarboxyphenyl)pyridine-2,6-dicarboxylic acid], two novel zinc-based metal-organic frameworks (MOFs) {[Zn3(ddp)2(H2O)4]·3H2O}n (Zn1-ddp) and {[Zn3(ddp)2(H2O)4]·3H2O}n (Zn2-ddp) were successfully designed by delicate structural regulation. Both Zn1-ddp and Zn2-ddp exhibited excellent water and chemical stability and showed excellent fluorescence quenching performance for tetracycline antibiotics. Notably, the more advanced framework structure and better fluorescent performance make Zn1-ddp more sensitive than Zn2-ddp in fluorescent detection with a detection limit of 0.29 µmol/L for tetracycline (TC), 0.09 µmol/L for doxycycline (DOX), 0.10 µmol/L for minocycline (MIN) and metacycline (MEL), 0.19 µmol/L for chlortetracycline (CTC), and 0.67 µmol/L for oxytetracycline (OTC) among tetracycline antibiotics. The fluorescence quenching mechanism of Zn1-ddp and Zn2-ddp for tetracycline antibiotics detection was deeply investigated. The reasons for the superior detection performance of Zn1-ddp over Zn2-ddp were also analyzed in depth through Fourier transform infrared spectrophotometry (FTIR), X-ray photoelectron spectroscopy (XPS) analysis and framework structure analysis. The developed method opens up a new perspective for antibiotics detection based on zinc-based MOFs.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 22072034 and 22001050).

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  1. The authors contributed equally to this work.

Authors and Affiliations

  1. MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, P. R. China

    He Tao, Chengshan Ji, Jian Zhang, Yuanyuan Yin, Wenwen Jia, Xin Jiang, Jie Xu & Yulin Yang

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  1. He Tao
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  2. Chengshan Ji
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  3. Jian Zhang
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  4. Yuanyuan Yin
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  6. Xin Jiang
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Correspondence to Jian Zhang.

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Elaborate Design of Two Novel Fluorescent Zinc-Based Metal-Organic Frameworks for Highly Efficient Tetracycline Antibiotics Detection

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Tao, H., Ji, C., Zhang, J. et al. Elaborate Design of Two Novel Fluorescent Zinc-based Metal-Organic Frameworks for Highly Efficient Tetracycline Antibiotics Detection. Chem. Res. Chin. Univ. (2024). https://doi.org/10.1007/s40242-024-4043-3

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