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A Review on Nanomaterial-based Strategies for Manipulating Tumor Microenvironment to Enhance Chemodynamic Therapy

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Chemical Research in Chinese Universities Aims and scope

Abstract

Cancer is a leading cause of death worldwide, and a series of strategies has been reported for tumor-specific therapy. Currently, chemodynamic therapy (CDT) has become a research hotspot for antitumor treatment due to its advantages of high specificity, endogenous stimulation, and high biosafety. However, the therapeutic effects of CDT are normally limited in the complex tumor microenvironment (TME), such as insufficient acidity, tumor hypoxia, low hydrogen peroxide (H2O2), and high glutathione (GSH). Consequently, different kinds of multifunctional nanomaterials have been designed to manipulate TME conditions, which provided more opportunities to improve the efficiency of CDT. This review focuses on nanomaterial-based strategies for enhancing CDT through manipulating TME. Upon CDT enhancements, this review would provide a reference for the future development of efficient CDT nanomaterials.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 22274012, 21974010), the Fundamental Research Funds for the Central Universities, China (No. 2233300007) and the Key Project of Science and Technology Plan of Beijing Education Commission, China (No. KZ20231002807).

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Authors and Affiliations

  1. Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, 100875, P. R. China

    Mengyu Cao, Xiaotong Shen & Na Na

  2. Department of Chemistry, College of Arts and Sciences, Beijing Normal University at Zhuhai, Zhuhai, 519087, P. R. China

    Jin Ouyang

  3. State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan, 430074, P. R. China

    Xiner Xing

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  1. Mengyu Cao
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Correspondence to Xiaotong Shen or Na Na.

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NA Na is a youth executive editorial board member for Chemical Research in Chinese Universities and was not involved in the editorial review or the decision to publish this article. The authors declare no conflicts of interest.

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Cao, M., Xing, X., Shen, X. et al. A Review on Nanomaterial-based Strategies for Manipulating Tumor Microenvironment to Enhance Chemodynamic Therapy. Chem. Res. Chin. Univ. 40, 202–212 (2024). https://doi.org/10.1007/s40242-024-3267-6

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