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Progress in DNA Aptamers as Recognition Components for Protein Functional Regulation

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Chemical Research in Chinese Universities Aims and scope

Abstract

Proteins play a central role in all domains of life, and precise regulation of their activity is essential for understanding the related biological processes and therapeutic functions. Nucleic acid aptamers, the molecular recognition components derived from systematic evolution of ligands by exponential enrichment(SELEX), can specifically identify proteins with antibody-like recognition characteristics and help to regulate their activity. This minireview covers the SELEX-based selection of protein-binding aptamers, membrane protein analytical techniques based on aptamer-mediated target recognition, aptamer-mediated functional regulation of proteins, including membrane receptors and non-membrane proteins(thrombin as a model), as well as the potential challenges and prospects regarding aptamer-mediated protein manipulation, aiming to supply some useful information for researchers in this field.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China(No. 21904046).

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Authors and Affiliations

  1. College of Science, Huazhong Agricultural University, Wuhan, 430070, P. R. China

    Lingling Hu, Ke Liu, Guolan Ren, Jiangong Liang & Yuan Wu

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  1. Lingling Hu
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  2. Ke Liu
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  3. Guolan Ren
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  4. Jiangong Liang
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  5. Yuan Wu
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Correspondence to Yuan Wu.

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Hu, L., Liu, K., Ren, G. et al. Progress in DNA Aptamers as Recognition Components for Protein Functional Regulation. Chem. Res. Chin. Univ. 38, 894–901 (2022). https://doi.org/10.1007/s40242-022-2124-8

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