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Study on the Interaction and Properties of Cucurbit[8]uril with Oroxin B

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Chemical Research in Chinese Universities Aims and scope

Abstract

The interaction between cucurbit[8]uril(Q[8]) and oroxin B(ORB) was investigated by UV-visible(UV-Vis) spectroscopy, isothermal titration calorimetry(ITC), mass spectrum(MS) and nuclear magnetic resonance(NMR) spectroscopy. The results showed that ORB formed a 2:1 inclusion complex with Q[8] with a binding constant of 8.266×105 L2·mol−2. ORB had good scavenging ability for 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulphonate)(ABTS) free radicals(IC50=5.74 µmol/L) and the addition of Q[8] did not significantly affect the antioxidant activity of ORB(IC50=5.76 µmol/L). A phase solubility experiment revealed a 1.86-fold increase in the solubility of ORB when c(Q[8])=100 µmol/L. In vitro drug release experiments showed that the release rate for ORB@Q[8] complex was lower than that of ORB in artificial intestinal juice, and higher than that of ORB in artificial gastric juice.

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Authors and Affiliations

  1. Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, College of Chemistry and Chemical Engineering, Guizhou University, Guiyang, 550025, P. R. China

    Jun Xie, Zhishu Zeng, Zhu Tao & Qianjun Zhang

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  1. Jun Xie
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  2. Zhishu Zeng
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  3. Zhu Tao
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  4. Qianjun Zhang
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Correspondence to Qianjun Zhang.

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Xie, J., Zeng, Z., Tao, Z. et al. Study on the Interaction and Properties of Cucurbit[8]uril with Oroxin B. Chem. Res. Chin. Univ. 36, 804–809 (2020). https://doi.org/10.1007/s40242-020-0005-6

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  • DOI: https://doi.org/10.1007/s40242-020-0005-6

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