Skip to main content
SpringerLink
Log in

Exploration of Zinc(II) Complexes as Potent Inhibitors Against Protein Tyrosine Phosphatase 1B

  • Published:
Chemical Research in Chinese Universities Aims and scope

Abstract

Although protein tyrosine phosphatases(PTPs) do not contain any metals, their activities can be inhibited by some metal complexes. Here we investigated the inhibition of two zinc complexes with Schiff base ligands against PTPs activity to explore their effect on the cellular metabolism. It has been found that they are potent inhibitors against four recombinant PTPs, including protein tyrosine phosphatase 1B(PTP1B), T cell protein tyrosine phosphatase( TCPTP), megakaryocyte protein tyrosine phosphatase 2(PTP-MEG2), and Src-homology phosphatase 1(SHP-1), with exception of Src-homology phosphatase 2(SHP-2). Moreover, they showed moderate selective inhibition against PTP1B with the IC50 values of 0.15 and 0.36 μmol/L. Meanwhile, the complexes also inhibited cellular phosphatase activities efficiently. Comparing the inhibitory potency over PTPs mediated by the zinc ion, we found that zinc complexes might be easily developed into potent and selective inhibitors against certain PTP by rationally modifying the organic ligands moieties.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Alonso A., Sasin J., Bottini N., Friedberg I., Osterman A., Godzik A., Hunter T., Dixon J., Mustelin T., Cell, 2004, 117(6), 699

    Article  CAS  PubMed  Google Scholar 

  2. Andersen J. N., Mortensen O. H., Peters G. H., Drake P. G., Iversen L. F., Olsen O. H., Jansen P. G., Andersen H. S., Tonks N. K., Moller N. P. H., Mol. Cell. Biol., 2001, 21(21), 7117

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Shivani V., Saurabh S., Curr. Mol. Pharmacol., 2018, 11(3), 191

    Article  CAS  Google Scholar 

  4. Hale A. J., ter Steege E., den Hergog J., Dev. Biol., 2017, 428(2), 283

    Article  CAS  PubMed  Google Scholar 

  5. Bollu L. R., Mazumdar A., Savage M. I., Brown P. H., Clin. Cancer Res., 2017, 23(9), 2136

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Ruddraraju K. V., Zhang Z. Y., Mol. Biosyst., 2017, 13, 1257

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Zhang C. L., Sun X. N., Li C. Y., Cai J. Y., Wang J., Li Y. Z., Wang H. Y., Chem. J. Chinese Universities, 2017, 38(10), 1764

    CAS  Google Scholar 

  8. Chai Q., Shen Q., Ma L. P., Wang X., Meng T., Li J. Y., Li J., Shen J. K., Chem. J. Chinese Universities, 2011, 32(2), 306

    CAS  Google Scholar 

  9. Lu L. P., Zhu M. L., Antioxid. Redox Signal., 2014, 20(14), 2210

    Article  CAS  PubMed  Google Scholar 

  10. Jia Y., Lu L., Zhu M., Yuan C., Xing S., Fu X., Eur. J. Med. Chem., 2017, 128, 287

    Article  CAS  PubMed  Google Scholar 

  11. Li Y. H., Yuan C. X., Lu L. P., Zhu M. L., Fu X. Q., Xing S., Gao Z. Q., Chem. J. Chinese Universities, 2016, 37(12), 2138

    CAS  Google Scholar 

  12. Maywald M., Wessels I., Rink L., Int. J. Mol. Sci., 2017, 18(11), 2222

    Article  CAS  PubMed Central  Google Scholar 

  13. Maret W., Biometals, 2013, 26(2), 197

    Article  CAS  PubMed  Google Scholar 

  14. Bellomo E., Massarotti A., Hogstrand C., Maret W., Metallomics, 2014, 6(7), 1229

    Article  CAS  PubMed  Google Scholar 

  15. Haase H., Maret W., Biometals, 2005, 18(4), 333

    Article  CAS  PubMed  Google Scholar 

  16. Wilson M., Hogstrand C., Maret W., J. Biol. Chem., 2012, 287(12), 9322

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Price K. A., Caragounis A., Paterson B. M., Filiz G., Volitakis I., Masters C. L., Barnham K. J., Donnelly P. S., Crouch P. J., White A. R., J. Med. Chem., 2009, 52(21), 6606

    Article  CAS  PubMed  Google Scholar 

  18. Yuan C., Lu L., Gao X., Wu Y., Guo M., Li Y., Fu X., Zhu M., J. Biol. Inorg. Chem., 2009, 14(6), 841

    Article  CAS  PubMed  Google Scholar 

  19. Zhang L., Zhang S. T., Zhang X. P., Sun J., Wang Y. S., Liu Y. L., Xue M. M., Wang Z., Xing S., Ma J. F., Li W. N., Fu X. Q., Chem. Res. Chinese Universities, 2013, 29(4), 730

    Article  CAS  Google Scholar 

  20. Yuan C. X., Lan S. F., Lu L. P., Chin. J. Inorg. Chem., 2015, 31(5), 915

    CAS  Google Scholar 

  21. Clague M. J., Keder N. L, Butler A., Inorg. Chem., 1993, 32(22), 4754

    Article  CAS  Google Scholar 

  22. Sheldrick G. M., Correction Software, University of Göttingen, Göttingen, 1996

    Google Scholar 

  23. Sheldrick G. M., Program for the Solution of Crystal Structure, University of Göttingen, Göttingen, 1997

    Google Scholar 

  24. Farrugia L. J., J. Appl. Cryst., 1997, 30, 565

    Article  CAS  Google Scholar 

  25. Ma L., Lu L., Zhu M., Wang Q., Li Y., Xing S., Fu X., Gao Z., Dong Y., Dalton Trans., 2011, 40(24), 6532

    Article  CAS  PubMed  Google Scholar 

  26. Woolley E. M., Tomkins J., Hepler L. G., J. Sol. Chem., 1972, 1, 341

    Article  CAS  Google Scholar 

  27. Yuan C., Lu L., Wu Y., Liu Z., Guo M., Xing S., Fu X., Zhu M., J. Inorg. Biochem., 2010, 104(9), 978

    Article  CAS  PubMed  Google Scholar 

  28. Alain M., Michel B., Michel D., J. Chem. Edu., 1986, 63, 365

    Article  Google Scholar 

  29. Kumar S. M., Rajesh J., Anitha K., Dhahagani K., Marappan M., Gandhi N. I., Rajagopal G., Spectrochim. Acta A, 2015, 142(5), 292

    Google Scholar 

  30. Gans P., Sabatini A., Vacca A., J. Chem. Soc., Dalton Trans., 1985, 1195

    Google Scholar 

  31. Yuan C., Zhu M., Wang Q., Lu L., Xing S., Fu X., Jiang Z., Zhang S., Li Z., Zhu R., Ma L., Xu L., Chem. Commun., 2012, 48, 1153

    Article  CAS  Google Scholar 

  32. Ding F., Zhao G., Huang J., Sun Y., Zhang L., Eur. J. Med. Chem., 2009, 44(10), 4083

    Article  CAS  PubMed  Google Scholar 

  33. Haj F. G., Markova B., Klaman L. D., Bohmer F. D., Neel B. G., J. Biol. Chem., 2003, 278, 739

    Article  CAS  PubMed  Google Scholar 

  34. Zhang S., Chen L., Luo Y., Gunawan A., Lawrence D. S., Zhang Z. Y., J. Am. Chem. Soc., 2009, 131, 13072

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Yuan T., Wang Y., Zhao Z. J., Gu H., J. Bio. Chem., 2010, 285(20), 14861

    Article  CAS  Google Scholar 

  36. Chen Q., Lu L. P., Chinese J. Inorg. Chem., 2016, 32(6), 1001

    CAS  Google Scholar 

  37. Li Y. H., Lu L. P., Zhu M. L., Yuan C. X., Feng S. S., Gao Z. Q., Chinese J. Struct. Chem., 2017, 36(2), 316

    Google Scholar 

  38. Seale A. P., de Jesus L. A., Kim S., Choi Y., Lim H. B., Hwang C., Kim Y., Biotechnol. Lett., 2005, 27, 221

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Key Laboratory of Chemical Biology and Molecular Engineering, Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan, 030006, P. R. China

    Xinhua Li, Caixia Yuan, Liping Lu & Miaoli Zhu

  2. Edmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin University, Changchun, 130012, P. R. China

    Shu Xing & Xueqi Fu

Authors
  1. Xinhua Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Caixia Yuan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Liping Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Miaoli Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Shu Xing
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Xueqi Fu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Caixia Yuan or Shu Xing.

Additional information

Supported by the National Natural Science Foundation of China(Nos.21471092, 21571118) and the Project of the Scientific Instrument Center of Shanxi University of China.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, X., Yuan, C., Lu, L. et al. Exploration of Zinc(II) Complexes as Potent Inhibitors Against Protein Tyrosine Phosphatase 1B. Chem. Res. Chin. Univ. 35, 186–192 (2019). https://doi.org/10.1007/s40242-019-8265-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40242-019-8265-8

Keywords

Search

Navigation