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Construction of pH-Triggered DNA Hydrogels Based on Hybridization Chain Reactions

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Abstract

As a novel type of bio-functional material, DNA hydrogels have attracted more and more attention due to their successful applications in 3D cell culturing and tissue engineering for the designable and programmable responsiveness. Herein, we have developed a pH-triggered DNA hydrogel based on a clamped hybridization chain reaction(C-HCR). In this system, a DNA switch was designed, which can release the initiator strand in a controllable way via the formation of the C-G·C+ triplex under the pH stimuli. While the pre-gelation solution is stable in neutral environment, the C-HCR will trigger the sol-gel transition as the pH decreased to 5.0. This strategy has endowed the DNA hydrogel with good controllability for triggering, which also shows potential in intellectual responsiveness to certain stimuli.

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Authors and Affiliations

  1. Key Laboratory of Organic Optoelectronics & Molecular Engineering, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China

    Yujie Li & Dongsheng Liu

  2. School of Chemical Science and Engineering, Shanghai Research Institute for Intelligent Autonomous Systems, Key Laboratory of Advanced Civil Engineering Materials, Ministry of Education, Tongji University, Shanghai, 200092, P. R. China

    Yujie Li & Huajie Liu

  3. Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, P. R. China

    Jie Chen

  4. CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China

    Yuanchen Dong

Authors
  1. Yujie Li
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  2. Jie Chen
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  3. Yuanchen Dong
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  4. Huajie Liu
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  5. Dongsheng Liu
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Corresponding authors

Correspondence to Huajie Liu or Dongsheng Liu.

Additional information

Supported by the National Natural Science Foundation of China(Nos.21890731, 21534007, 21821001, 21722310).

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Li, Y., Chen, J., Dong, Y. et al. Construction of pH-Triggered DNA Hydrogels Based on Hybridization Chain Reactions. Chem. Res. Chin. Univ. 36, 243–246 (2020). https://doi.org/10.1007/s40242-019-0034-1

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  • DOI: https://doi.org/10.1007/s40242-019-0034-1

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