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A Highly Selective and Sensitive Ratiometric Fluorescent Probe for Hypochlorite and Its Application

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Abstract

A novel water-soluble hybrid fluorescein-coumarin dye(FLNC) fluorescence ratiometric probe to recognize OCl− was designed and synthesized. The most prominent feature of the probe is that the molecular structure contains two different fluorophores, and the fluorescein moiety was connected to coumarin moiety by diacylhydrazine linker. When OCl− was added, the two fluorophores in the FLNC probe could have a rapid respond simultaneously, with high selectivity and sensitivity towards OCl– among other reactive oxygen species/reactive nitrogen species(ROS/RNS) and anions, and the detection limit was measured to be 0.30 μmol/L. In addition, the color changes of the solution could be observed by the naked eye and have a short response time(completed within 1 min), which suggestes that the probe FLNC has the potential to be used for real-time detection.

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Authors and Affiliations

  1. China-Japan Union Hospital, Jilin University, Changchun, 130031, P. R. China

    Longqi Xue, Dahai Liu & Jianshi Du

  2. College of Chemistry, Jilin University, Changchun, 130021, P. R. China

    Longqi Xue, Yusha Feng, Rui Wang, Qingbiao Yang & Yaoxian Li

  3. College of Materials Science and Engineering, Jilin University of Chemical Technology, Jilin, 132022, P. R. China

    Yusha Feng & Yan Song

Authors
  1. Longqi Xue
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  2. Yusha Feng
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  3. Yan Song
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  4. Rui Wang
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  5. Dahai Liu
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  6. Jianshi Du
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  7. Qingbiao Yang
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  8. Yaoxian Li
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Corresponding author

Correspondence to Jianshi Du.

Additional information

Supported by the Natural Science Foundation of Jilin Province, China(Nos.20160101311JC, 20170101105JC) and the Jilin Provincial Science and Technology Research Plan, China(No.20170204039GX).

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Xue, L., Feng, Y., Song, Y. et al. A Highly Selective and Sensitive Ratiometric Fluorescent Probe for Hypochlorite and Its Application. Chem. Res. Chin. Univ. 34, 536–540 (2018). https://doi.org/10.1007/s40242-018-8028-y

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  • DOI: https://doi.org/10.1007/s40242-018-8028-y

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