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CXCR4 Peptide Conjugated Au-Fe2O3 Nanoparticles for Tumor-targeting Magnetic Resonance Imaging

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Abstract

Peptide-functionalized Au-Fe2O3 nanoparticles(termed as anti-CXCR4-Au-Fe2O3 NPs) have been constructed through conjugation of dumbbell-like Au-Fe2O3 NPs with C-X-C motif chemokine receptor 4(CXCR4) binding cyclic peptide. One dumbbell-like Au-Fe2O3 NP composes an Au NP[(3.3±0.3) nm in diameter] for conjugating CXCR4 binding cyclic peptide through Au-S covalent bond and a Fe2O3 NP[(8.7±0.8) nm in diameter] for using as T2-weighted magnetic resonance imaging(MRI) contrast agent. The anti-CXCR4-Au-Fe2O3 NPs have reasonable biocompatibility and integration of T2-weighted MRI contrast and tumor-targeting functionalities. The anti-CXCR4-Au-Fe2O3 NPs exhibit strong interactions with two kinds of breast tumor cells, MCF-7 cells and MDA-MB-231 cells, and high negative contrast in MRI of MDA-MB-231 tumor bearing mouse with 62% decreasing of MRI signal, indicating that the anti-CXCR4-Au-Fe2O3 NPs can recognize tumor with high efficacy and specificity.

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Authors and Affiliations

  1. Department of Radiology, China-Japan Union Hospital of Jilin University, Changchun, 130033, P. R. China

    Guifeng Liu & Shaonan Yu

  2. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China

    Hongda Chen & Zhenxin Wang

  3. Department of Radiology, the First Hospital of Jilin University, Changchun, 130021, P. R. China

    Xiaodong Li

Authors
  1. Guifeng Liu
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  2. Hongda Chen
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  3. Shaonan Yu
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  4. Xiaodong Li
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  5. Zhenxin Wang
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Corresponding author

Correspondence to Zhenxin Wang.

Additional information

Supported by the National Natural Science Foundation of China(No.80151459).

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Liu, G., Chen, H., Yu, S. et al. CXCR4 Peptide Conjugated Au-Fe2O3 Nanoparticles for Tumor-targeting Magnetic Resonance Imaging. Chem. Res. Chin. Univ. 34, 584–589 (2018). https://doi.org/10.1007/s40242-018-8010-8

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  • DOI: https://doi.org/10.1007/s40242-018-8010-8

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