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Chemical Research in Chinese Universities

, Volume 33, Issue 6, pp 890–894 | Cite as

Total synthesis and biological evaluation of Wewakazole

  • Bohua Long
  • Jingzhao Zhang
  • Xueyan Wang
  • Xudong Tang
  • Zhengzhi Wu
Article

Abstract

The total synthesis of Wewakazole was achieved on a gram scale, unambiguously confirming its structure. Three different substituted oxazoles present in this natural product were prepared efficiently. Biological evaluation indicated that Wewakazole significantly inhibited cancer cell proliferation in a dose-dependent manner.

Keywords

Wewakazole Total synthesis Biological evaluation 

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Supplementary material

40242_2017_7129_MOESM1_ESM.pdf (2.3 mb)
Total Synthesis of Wewakazole

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Copyright information

© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH Germany, part of Springer Nature 2017

Authors and Affiliations

  • Bohua Long
    • 1
    • 2
    • 3
  • Jingzhao Zhang
    • 4
  • Xueyan Wang
    • 4
  • Xudong Tang
    • 4
  • Zhengzhi Wu
    • 1
    • 2
    • 3
  1. 1.The Fourth People’s Hospital of ShenzhenShenzhenP. R. China
  2. 2.Shenzhen Institute of GeriatricsShenzhenP. R. China
  3. 3.The Second People’s Hospital of ShenzhenShenzhenP. R. China
  4. 4.Key Lab for New Drug Research of TCM and Shenzhen Branch, State R&D Centre for Viro-BiotechResearch Institute of Tsinghua University in ShenzhenShenzhenP. R. China

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