FeCl3·6H2O-catalyzed synthesis of β-ketothioesters from chain α-oxo ketene dithioactals
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A FeCl3·6H2O-catalyzed synthesis of β-ketothioesters from the hydrolysis reaction of chain α-oxoketene dithioacetals was carried out. Subsequently, we explored the FeCl3·6H2O-catalyzed Friedel-Crafts alkylation of the synthesized β-ketothioesters with alcohols in CH3CN at 25 °C, affording the desired α-alkylated β-ketothioesters in excellent yields. Wide scope of the substrates, use of inexpensive reagents, high yields under mild reaction conditions are notable features of these reactions.
KeywordsIron(III) chloride Thioester Ketene dithioacetal Hydrolysis Friedel-Crafts alkylation
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