Two new baccharane glycosides from seeds of Impatientis balsamina L. with in vitro growth inhibitory activity in human cancer A375 cells
- 46 Downloads
Two new baccharane-type glycosides (1 and 2), together with seven known baccharane-type glycosides (3―9) hosenkoside A, hosenkoside B, hosenkoside C, hosenkoside F, hosenkoside M, hosenkoside K and hosenkoside G were isolated from the dried seeds of Impatientis balsamina L. The new baccharane-type glycosides were identified as honsenkol A-3-O-β-D-glucopyranosyl-26-O-β-D-glucopyranosyl-28-O-β-D-glucopyranosyl-O-β-D-glucopyranosyl(1) and (3S,4R,17R,20S)-17-hydroxy-3-O-β-D-xylopyranose(12)-β-D-glucopyranosyl-26-O-β-D-glucopyranosyl-28-O-β-D-glucopyranosyl-21,24-epoxybaccharane(2), respectively, by spectroscopic methods, including NMR(1D and 2D), IR and HR-ESI-MS. Compounds 1 and 2 were evaluated for in vitro inhibitory activity against the cell lines. Compound 2 with a new baccharane skeleton had anti-hepatic fibrosis activity against A375 cells in bioassay results, which means the new compounds have potential value in antitumor applications.
KeywordsImpatientis balsamina L. Seed Baccharane-type glycoside Cytotoxic activity
Unable to display preview. Download preview PDF.
- Li Q. G., Hu D. M., Li Y. F., China Pharm., 2012, 2, 262Google Scholar
- Tan L. N., Lu J., Zhu N., Chin. J. Pharm. Anal., 2009, 29(5), 717Google Scholar
- Meng L., Li Q. M., Tong Y. N., Jin Y. R., J. Jilin University Sci. Ed., 2011, 49(5), 951Google Scholar
- Lei J., Qian S. H., Jiang J. Q., J. China Pharm.Univ., 2010, 41(2), 118Google Scholar
- Chen M. X., Wang X. L., Zhang Y. J., Chin. Mat. Med., 2006, 31(11), 928Google Scholar
- Rumampuk R. J., Pongoh E. J., Tarigan P., Herlt A. J., Mander L. N., Indones. J. Chem., 2010, 3(3), 149Google Scholar
- Pavela R., Vrchotová N., Será B., Biopesticides, 2009, 2(1), 48Google Scholar