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Chemical Research in Chinese Universities

, Volume 33, Issue 5, pp 753–757 | Cite as

Two new baccharane glycosides from seeds of Impatientis balsamina L. with in vitro growth inhibitory activity in human cancer A375 cells

  • Qian Wu
  • Yongri Jin
  • Hua Yao
  • Ying Liu
  • Peng Li
  • Xuwen Li
Article
  • 51 Downloads

Abstract

Two new baccharane-type glycosides (1 and 2), together with seven known baccharane-type glycosides (39) hosenkoside A, hosenkoside B, hosenkoside C, hosenkoside F, hosenkoside M, hosenkoside K and hosenkoside G were isolated from the dried seeds of Impatientis balsamina L. The new baccharane-type glycosides were identified as honsenkol A-3-O-β-D-glucopyranosyl-26-O-β-D-glucopyranosyl-28-O-β-D-glucopyranosyl-O-β-D-glucopyranosyl(1) and (3S,4R,17R,20S)-17-hydroxy-3-O-β-D-xylopyranose(12)-β-D-glucopyranosyl-26-O-β-D-glucopyranosyl-28-O-β-D-glucopyranosyl-21,24-epoxybaccharane(2), respectively, by spectroscopic methods, including NMR(1D and 2D), IR and HR-ESI-MS. Compounds 1 and 2 were evaluated for in vitro inhibitory activity against the cell lines. Compound 2 with a new baccharane skeleton had anti-hepatic fibrosis activity against A375 cells in bioassay results, which means the new compounds have potential value in antitumor applications.

Keywords

Impatientis balsamina L. Seed Baccharane-type glycoside Cytotoxic activity 

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References

  1. [1]
    Li H. J., Yu J. J., Li P., J. Pharm. Biomed. Anal., 2011, 54(4), 674CrossRefGoogle Scholar
  2. [2]
    Li Q. G., Hu D. M., Li Y. F., China Pharm., 2012, 2, 262Google Scholar
  3. [3]
    Lei J., Qian S. H., Jiang J. Q., J.Asian Nat. Prod. Res., 2010, 12(12), 1033CrossRefGoogle Scholar
  4. [4]
    Shoji N., Umeyama A., Taira Z., Takemoto T., Nomoto K., Mizuka-wa K., Ohizumi Y., J. Chem. Soc. Chem. Commun., 1983, 16(16), 871CrossRefGoogle Scholar
  5. [5]
    Shoji N., Umeyama A., Yoshikawa K., Kan Y., Arihara S., Tetrahe-dron, 1994, 50(17), 4973CrossRefGoogle Scholar
  6. [6]
    Shoji N., Umeyama A., Saitou N., Yoshikawa K., Nagai M., Arihara S., Chem. Pharm. Bull., 1994, 42(7), 1422CrossRefGoogle Scholar
  7. [7]
    Shoji N., Umeyama A., Saitou N., Yoshikawa K., Nagai M., Arihara S., Phytochemistry, 1994, 37(37), 1437CrossRefGoogle Scholar
  8. [8]
    Tan L. N., Lu J., Zhu N., Chin. J. Pharm. Anal., 2009, 29(5), 717Google Scholar
  9. [9]
    Meng L., Li Q. M., Tong Y. N., Jin Y. R., J. Jilin University Sci. Ed., 2011, 49(5), 951Google Scholar
  10. [10]
    Lei J., Qian S. H., Jiang J. Q., J. China Pharm.Univ., 2010, 41(2), 118Google Scholar
  11. [11]
    Chen M. X., Wang X. L., Zhang Y. J., Chin. Mat. Med., 2006, 31(11), 928Google Scholar
  12. [12]
    Rumampuk R. J., Pongoh E. J., Tarigan P., Herlt A. J., Mander L. N., Indones. J. Chem., 2010, 3(3), 149Google Scholar
  13. [13]
    Zhou X. F., Zhao X. Y., Tang L., Ruan H. L., Zhang Y. H., Pi H. F., Wu J. Z., J. Asian Nat. Prod. Res., 2007, 9(4), 379CrossRefGoogle Scholar
  14. [14]
    Motz V. A., Bowers C. P., Kneubehl A. R., Lendrum E. C., Young L. M., Kinder D. H., J. Ethnopharmacol., 2015, 162(4), 163CrossRefGoogle Scholar
  15. [15]
    Motz V. A., Bowers C. P., Young L. M., Kinder D. H., J. Ethnophar-macol., 2012, 143(1), 314CrossRefGoogle Scholar
  16. [16]
    Pavela R., Vrchotová N., Será B., Biopesticides, 2009, 2(1), 48Google Scholar
  17. [17]
    Yang J., Yu X., Chen Y. X., Zhang H. M., Li X. W., Jin Y. R., Chem. Res. Chinese Universities, 2016, 32(1), 35CrossRefGoogle Scholar
  18. [18]
    Li M., Jin Y. R., Wang X. Z., Wu Q., Liu Y., Li P., Chem. Res. Chinese Universities, 2016, 32(6), 943CrossRefGoogle Scholar

Copyright information

© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Qian Wu
    • 1
  • Yongri Jin
    • 1
  • Hua Yao
    • 2
  • Ying Liu
    • 1
  • Peng Li
    • 1
  • Xuwen Li
    • 1
  1. 1.College of ChemistryJilin UniversityChangchunP. R. China
  2. 2.Scientific Research CenterChina-Japan Union Hospital of Jilin UniversityChangchunP. R. China

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