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Disulfide-crosslinked poly(L-glutamic acid) grafted mesoporous silica nanoparticles and their potential application in drug delivery

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Abstract

Poly(L-glutamic acid)(PLGA) was grafted onto the surface of mesoporous silica nanoparticles(MSN) via the ring opening polymerization of γ-benzyl-L-glutamate N-carboxyanhydride(BLG-NCA) and its subsequent deprotection of benzyl groups. The PLGA chains were cross-linked with cystamine, and thus forming a type of redox responsive drug delivery system(MSN-cPLGA). The structures were characterized by Fourier transform infrared spectrometry(FTIR), transmission electron microscopy(TEM) and energy disperse spectrometry(EDS), demonstrating that disulfide groups existed on the surfaces of MSN-cPLGA particles. The thermal gravimetric analysis(TGA) results show that the PLGA mass fraction is about 33.4% in the MSN-cPLGA hybrid. The in vitro drug release experiments showed that the MSN-cPLGA hybrid can realize the controlled release of model drugs(5-fluorouracil) in response to redox environment. Even 0.1 mmol/L dithiothreitol(DTT) can accelerate the drug release speed, and a concentration of 10.0 mmol/L DTT is higher enough to trigger the open of cross-linked PLGA network so as to realize rapid release of drugs. All the results demonstrate that the cross-linked PLGA chains on the surface of MSN could act as efficient gatekeepers to control the on-off of the pores, showing potential application in drug delivery system.

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Authors and Affiliations

  1. Department of Chemistry, Nanchang University, Nanchang, 330031, P. R. China

    Huiyong Wu, Jianhui Li, Junchao Wei, Yanfeng Dai, Zhiping Peng, Yiwang Chen & Tianxi Liu

  2. State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200433, P. R. China

    Tianxi Liu

Authors
  1. Huiyong Wu
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  2. Jianhui Li
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  3. Junchao Wei
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  4. Yanfeng Dai
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  5. Zhiping Peng
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  6. Yiwang Chen
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  7. Tianxi Liu
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Corresponding author

Correspondence to Junchao Wei.

Additional information

Supported by the National Natural Science Foundation of China(Nos.51203073, 51463013, 51263017) and the Natural Science Foundation of Jiangxi Province, China(Nos.20142BAB203018, 20151BAB206011).

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Wu, H., Li, J., Wei, J. et al. Disulfide-crosslinked poly(L-glutamic acid) grafted mesoporous silica nanoparticles and their potential application in drug delivery. Chem. Res. Chin. Univ. 31, 890–894 (2015). https://doi.org/10.1007/s40242-015-5075-5

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  • DOI: https://doi.org/10.1007/s40242-015-5075-5

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