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RETRACTED ARTICLE: Synthesis and biological evaluation of entecavir 4′-ester derivatives

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Chemical Research in Chinese Universities Aims and scope

This article was retracted on 22 December 2015

Abstract

Entecavir can significantly inhibit the replication of HBV-DNA, reduce the HBV-DNA level in blood serum. But suffering from low oral bioavailability, entecavir has low intestinal membrane permeability and poor metabolic stability. In this study, 12 different derivatives of entecavir 4′-ester were regioselectively synthesized and their apical-to-basolateral permeabilities across Caco-2 cells and HBV-DNA inhibitory efficacies were evaluated. Most of the compounds showed high permeabilities across Caco-2 cells compared with entecavir, compounds 5b and 5e also exhibited comparable anti-HBV activities with that of entecavir, especially.

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Authors and Affiliations

  1. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China

    Deri Feng, Jiaan Liu, Shuang Liang, Yanyan Wang & Youjun Xu

Authors
  1. Deri Feng
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  2. Jiaan Liu
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  3. Shuang Liang
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  4. Yanyan Wang
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  5. Youjun Xu
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Corresponding author

Correspondence to Youjun Xu.

Additional information

Supported by the National Natural Science Foundation of China(No.51209024) and the Science and Technology Plan of Sichuan Province, China(No.2010JY0122).

This article is retracted because the corresponding author XU Youjun was put as the corresponding author without knowing anything before its publication. All were arranged by the first author, Mr. FENG Deri, in abnormal ways. Hence all other authors and XU states here that this paper has no relation with other authors and with Xu’s working university. XU also states that he has never used “xuyoujun65@163.com”as corresponding author contact email. Therefore XU declares that the paper should be withdrawn from the journal as soon as possible in case any negative effects on other authors and on this journal.

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Feng, D., Liu, J., Liang, S. et al. RETRACTED ARTICLE: Synthesis and biological evaluation of entecavir 4′-ester derivatives. Chem. Res. Chin. Univ. 30, 749–754 (2014). https://doi.org/10.1007/s40242-014-4183-y

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  • DOI: https://doi.org/10.1007/s40242-014-4183-y

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