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Design and synthesis of hydrazine and oxadiazole-containing derivatives of Sorafenib as antitumor agents

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Abstract

A series of hydrazine and oxadiazole analogs of Sorafenib was designed, synthesized and characterized by proton nuclear magnetic resonance(1H NMR) spectrometry and high resolution mass spectrometry(HRMS). The antiproliferative activities of these compounds against human colorectal carcinoma(HCT-116) and human breast cancer (MDA-MB-231) tumor cell lines were evaluated in vitro by MTT method[MTT=3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide]. The bioassay results suggest that most of the synthesized compounds have antitumor potential to HCT-116 cell line compared with MDA-MB-231 cell line. Compounds 8a, 8b, 8d, 8e, 9f and 9j competitive with Sorafenib demonstrated antiproliferative activities on HCT-116 cell line.

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Authors and Affiliations

  1. Key Laboratory of Chemical Biology, Ministry of Education, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Jinan, China

    Yuan-you Wang, Jian-zhen Liu, Xiao-yue Yu, De-zhi Yang & Gui-sen Zhao

  2. Qilu Hospital, Shandong University, Jinan, 250012, P. R. China

    Lin-na Zhang

Authors
  1. Yuan-you Wang
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  2. Jian-zhen Liu
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  3. Xiao-yue Yu
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  4. De-zhi Yang
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  5. Lin-na Zhang
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  6. Gui-sen Zhao
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Corresponding authors

Correspondence to Lin-na Zhang or Gui-sen Zhao.

Additional information

Supported by the National Natural Science Foundation of China(No.21072115) and the Student Training Programs for Innovation of Shandong University, China(No.201210422076).

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Wang, Yy., Liu, Jz., Yu, Xy. et al. Design and synthesis of hydrazine and oxadiazole-containing derivatives of Sorafenib as antitumor agents. Chem. Res. Chin. Univ. 29, 454–459 (2013). https://doi.org/10.1007/s40242-013-2490-3

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  • DOI: https://doi.org/10.1007/s40242-013-2490-3

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