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Synthesis and anti-HIV activity of Triazolo-fused 3′,4′-cyclic and 4′-spiro nucleoside analogues

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Abstract

Triazolo-fused 3′,4′-cyclic nucleoside 4′-spiro nucleoside analogues were synthesized by an intramolecular 1,3-dipolar cycloaddition of 4′-azido nucleoside derived azido-alkynes in a regio- and stereo-specific manner. The thymine nucleoside base in these target compounds was transformed into the corresponding 5-methyl cytosine component. The synthesized compounds were examined in an MAGI(multinuclear-activation galactosidase indicator) assay for exploring the anti-HIV activity and in a H9 T(human T lymphocytes H9) assay for measuring the cell toxicity.

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Authors and Affiliations

  1. College of Chemistry, Jilin University, Changchun, 130012, P. R. China

    Jing-bo Sun, Rong-wang Liu & Jin-chang Wu

  2. China-Japan Union Hospital of Jilin University, Changchun, 130033, P. R. China

    Li-li Xuan & Wei-chun Leng

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  1. Jing-bo Sun
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  2. Rong-wang Liu
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  3. Li-li Xuan
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  4. Wei-chun Leng
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  5. Jin-chang Wu
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Correspondence to Jin-chang Wu.

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Sun, Jb., Liu, Rw., Xuan, Ll. et al. Synthesis and anti-HIV activity of Triazolo-fused 3′,4′-cyclic and 4′-spiro nucleoside analogues. Chem. Res. Chin. Univ. 29, 473–476 (2013). https://doi.org/10.1007/s40242-013-2375-5

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  • DOI: https://doi.org/10.1007/s40242-013-2375-5

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