Abstract
A novel amphiphilic β-cyclodextrin/poly(L-aspartate)(β-CD-PASP) copolymer was prepared by ring-opening polymerization of polysuccinimide(PSI). This copolymer bears β-CD units along the macromolecular chain and the structure was characterized by infrared(IR) and proton nuclear magnetic resonance(1H NMR). The molecular weight of the copolymer was determined by gel permeation chromatography(GPC). The copolymer micelle were prepared by direct dissolution method. The critical micelle concentration(CMC) of the copolymer micelle was measured by flourescence technique with pyrene as probe. The size distribution of micelle was characterized on a dynamic laser light scattering particle size analyzer and its shape was observed by transmission electron microscopy(TEM). The results show that the copolymer could self-assemble into micelle with a low CMC, and the effective diameter of the micelle was 116.3 nm. The methotrexate(MTX)-loaded micelle were prepared and the drug loading content(DLC) was 22.86%. The MTX-loaded copolymer exhibited a better water-solubility than the free drug.
Similar content being viewed by others
References
Yang L. H., Chu H., Chen M. Q., Hu N., Zhao Y. F., Chem. Res. Chinese Universities, 2011, 27(2), 334
Yang Y. G., Liu D., Xia Y., Zhou Y. H., Zhong X. Y., Liu J., Chem. Res. Chinese Universities, 2011, 27(3), 345
Ji J. G., Zhang J. F., Hao S. L., Wu D. J., Liu L., Xu Y., Chem. Res. Chinese Universities, 2012, 28(1), 166
Jiang H. G., Yang Z. J., Zhou X. T., Fang Y. X., Ji H. B., Chin. J. Chem. Eng., 2012, 20(4), 784
Li B., Zhang L. M., Carbohydrate Polymers, 2008, 74, 390
Wang H. J., Ma J. B., He B. L., Chinese Journal of Polymer Science, 2000, 18(2), 155
Zhang J. X., Kristin E., Peter X. M., Journal of Controlled Release, 2010, 145, 116
Zhao Y., Chen S. J., Journal of Functional Polymers, 2004, 17(4), 595
Li P. Z., Li X. R., Zhou H. X., Chinese Journal of New Drugs, 2009, 18(3), 262
Masayuki T., Takeshi N., Polymer, 1997, 9(38), 4733
Huang Y., Synthesis of Novel Cyelodextrin Polymers and Study of Their Controlled Drug Release Mechanism, Northwestern Polytechnical University, Xi’an, 2004
Robert J., Kim L., Donlar C., Corrosion, 1996, 3(96), 24
Lodge T. P., Bang J., Hanley K. J., Langmuir, 2003, 2(19), 2103
Turro N. J., Chung C. J., Macromolecules, 1984, 1(17), 2123
Kalyanasundaram K., Thomas J. K., Journal of the American Chemical Society, 1977, (99), 2039
Yeon K. S., Gyun S. I., Journal of Controlled Release, 1998, (51), 13
Author information
Authors and Affiliations
Corresponding author
Additional information
Supported by the Fund of the Key Laboratory of Tianjin Biomedical Materials, China(No.2011-116-1).
Rights and permissions
About this article
Cite this article
Guo, Yl., Cui, Zs. & Han, M. Synthesis, micellization and characterization of novel amphiphilic β-cyclodextrin/poly(L-aspartate) copolymer. Chem. Res. Chin. Univ. 29, 603–606 (2013). https://doi.org/10.1007/s40242-013-2373-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40242-013-2373-7