Abstract
A series of new hydantoin compounds was synthesized with 3-bromo phenylacetic acid and 3,4-dimethylbromobenzene as starting material, 7-bromo-2-tetralone and 2-bromo-5,6,8,9-tetrahydro-7-benzocyclo-heptenone as intermediate and Ullmann reaction, Suzuki reaction and Bucherer-Berg’s reaction as key steps. The structures of the key intermediate and target compounds were confirmed by 1H NMR, 13C NMR, IR and MS. Bioactivity research showed that target compounds 6a, 6c, 6d, 6e and 15i had significant antitussive effect on the ammonia-induced cough of mice.
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Zhang, Ql., Song, Lj. & Wang, Es. Synthesis and antitussive effect of new hydantoin compounds. Chem. Res. Chin. Univ. 29, 76–81 (2013). https://doi.org/10.1007/s40242-012-2064-9
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DOI: https://doi.org/10.1007/s40242-012-2064-9