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Das Zusammenwirken von Rhodiola rosea (Eisenwurz) und Antidepressiva

The interaction of Rhodiola rosea and antidepressants. A case report

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An Erratum to this article was published on 27 April 2023

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Zusammenfassung

Anliegen

Rhodiola rosea (Eisenwurz) ist eine Hochgebirgspflanze aus den arktischen Gebieten Europas und Asiens, die als einzige aller Rhodiola-Arten spezifische Wirkstoffe, nämlich die Phenylpropanoide, beinhaltet. Rhodiola rosea wirkt beruhigend, antidepressiv, antriebssteigernd und stressmodulierend und moduliert Dopamin und Serotonin im Gehirn; Extrakte aus dem Rhizom können in Kombination mit anderen Arzneimitteln Nebenwirkungen mit sich bringen.

Methode

Anhand eines Fallberichts soll dieser Zusammenhang beschrieben werden.

Ergebnisse

Wir berichten über eine 68-jährige Patientin mit rezidivierender mittelgradiger Depression mit somatischem Syndrom (ICD-10 F33.11), die unter der Selbstmedikation von Eisenwurz bei gleichzeitiger Einnahme von Paroxetin u. a. vegetative Syndrome, Unruhe-Gefühl und leichtes Zittern entwickelt hatte.

Schlussfolgerungen

Rhodiola rosea kann mit anderen Arzneimitteln pharmakokinetische sowie -dynamische Interaktionsphänomene auslösen. Das Auftreten der Symptome der Patientin lässt sich am ehesten als serotonerges Syndrom erklären. Aufgrund der weitverbreiteten Verschreibung der Pflanze sollte an Wechselwirkungen und Risikoprofile gedacht werden.

Summary

Objective

Rhodiola rosea (Russian Rhodiola/Golden Root) is a high mountain plant from the arctic regions of Europe and Asia which has the active substance phenylpropanoide. It has sedative, anti-depressive, drive-enhancing and stress-modulated properties stimulating the distribution of dopamine and serotonin; in combination with other drugs, an increase of side effects and risk profile has to be expected.

Methods

A case report is presented in order to illustrate the interaction between Rhodiola rosea and antidepressants.

Results

We report the case of a 68-year-old female patient with recurrent moderate depressive disorder with somatic syndrome (ICD-10 F33.11) who developed vegetative syndrome, restlessness feeling and trembling since she began to ingest Rhodiola rosea in addition to paroxetine.

Conclusions

Prescribing Rhodiola rosea with paroxetine, pharmacokinetic and -dynamic interactions have to be assumed. The symptoms of the patient can be interpreted as a serotonergic syndrome. Because of its different effects, the plant is widely used. An increase of clinical relevant risks should be considered in the add-on treatments.

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Authors and Affiliations

  1. Psychiatrischer Dienst, Gesundheitsbezirk Bozen, Böhlerstrasse 5, 39100, Bozen, Italien

    Ignazio Maniscalco, Elda Toffol, Giancarlo Giupponi & Andreas Conca

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  1. Ignazio Maniscalco
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  2. Elda Toffol
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  3. Giancarlo Giupponi
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  4. Andreas Conca
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Correspondence to Ignazio Maniscalco.

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Maniscalco, I., Toffol, E., Giupponi, G. et al. Das Zusammenwirken von Rhodiola rosea (Eisenwurz) und Antidepressiva. Neuropsychiatr 29, 36–38 (2015). https://doi.org/10.1007/s40211-014-0124-8

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  • DOI: https://doi.org/10.1007/s40211-014-0124-8

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