Polymers in topical delivery of anti-psoriatic medications and other topical agents in overcoming the barriers of conventional treatment strategies

Progress in Biomaterials volume 10, pages1–17(2021)Cite this article

Abstract

In recent decades, topical treatments to dermal disorders have shown ineffectiveness in delivering the medication at a particular location without a suitable drug carrier. Psoriasis treatment is hindered because of the ineffective delivery and efficacy of conventional pharmaceutical treatment. In conventional medication formulation approach, it is difficult to breach the transdermal layer of a skin membrane for topical drugs, i.e. cyclosporine, methotrexate. This problem is further complicated by extreme disease-associated conditions such as hyperkeratosis and irritation. Intending to assure better drug delivery carriers, this review emphasizes the therapeutic efficacy of polymers and their potential to deliver the drug into the deeper layer of the skin membrane. The polymers are essential in structural and physiochemical perspectives as it works as a carrier for the medication. A vast variety of delivery carriers is available nowadays but their applicability in such dermal cases like psoriasis is still lacking due to less knowledge on an appropriate polymer. The current investigation of suitable polymer would assist in brushing our expertise to optimize the advantages of a wide spectrum of polymers to fulfill the topical targeting of psoriasis.

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References

  1. Abbina S, Parambath A (2018) 14 -PEGylation and its alternatives: a summary. In: Parambath A (ed) Engineering of Biomaterials for Drug Delivery Systems. Woodhead Pub, pp 363–376

  2. Abdelbary AA, Aboughaly MHH (2015) Design and optimization of topical methotrexate loaded niosomes for enhanced management of psoriasis: application of Box-Behnken design, in-vitro evaluation and in-vivo skin deposition study. Int J Pharm 485:235–243. https://doi.org/10.1016/j.ijpharm.2015.03.020

    CAS  Article  Google Scholar 

  3. Abdelgawad R, Nasr M, Hamza MY, Awad GAS (2016) Topical and systemic dermal carriers for psoriasis. Int J Curr Pharm Rev Res 8:4–9

    CAS  Google Scholar 

  4. Abdelgawad R, Nasr M, Moftah NH, Hamza MY (2017) Phospholipid membrane tubulation using ceramide doping “Cerosomes”: characterization and clinical application in psoriasis treatment. Eur J Pharm Sci 101:258–268. https://doi.org/10.1016/j.ejps.2017.02.030

    CAS  Article  Google Scholar 

  5. Abed SN, Deb PK, Surchi HS, et al (2019) Nanocarriers in Different Preclinical and Clinical Stages. Elsevier Inc

  6. Acharya U (2017) Formulation and evaluation of nano emulsion based system for transdermal delivery of antipsoriatic drug. World J Pharm Pharm Sci. https://doi.org/10.20959/wjpps20177-9430

  7. Agrawal U, Mehra NK, Gupta U, Jain NK (2013) Hyperbranched dendritic nano-carriers for topical delivery of dithranol. J Drug Target 21:497–506. https://doi.org/10.3109/1061186X.2013.771778

    CAS  Article  Google Scholar 

  8. Alama T, Kusamori K, Morishita M et al (2019) Mechanistic studies on the absorption-enhancing effects of gemini surfactant on the intestinal absorption of poorly absorbed hydrophilic drugs in rats. Pharmaceutics. https://doi.org/10.3390/pharmaceutics11040170

    Article  Google Scholar 

  9. Alvarez-Figueroa MJ, Blanco-Méndez J (2001) Transdermal delivery of methotrexate: Iontophoretic delivery from hydrogels and passive delivery from microemulsions. Int J Pharm 215:57–65. https://doi.org/10.1016/S0378-5173(00)00674-8

    CAS  Article  Google Scholar 

  10. Anselmo AC, Mitragotri S (2014) An overview of clinical and commercial impact of drug delivery systems. J Control Release 190:15–28. https://doi.org/10.1016/j.jconrel.2014.03.053

    CAS  Article  Google Scholar 

  11. Avasatthi V, Pawar H, Dora CP et al (2016) A novel nanogel formulation of methotrexate for topical treatment of psoriasis: optimization, in vitro and in vivo evaluation. Pharm Dev Technol 21:554–562. https://doi.org/10.3109/10837450.2015.1026605

    CAS  Article  Google Scholar 

  12. Badıllı U, Sen T, Tarımcı N (2011) Microparticulate based topical delivery system of clobetasol propionate. AAPS PharmSciTech 12:949–957. https://doi.org/10.1208/s12249-011-9661-7

    CAS  Article  Google Scholar 

  13. Bakshi H, Nagpal M, Singh M et al (2020) Treatment of psoriasis: a comprehensive review of entire therapies. Curr Drug Saf. https://doi.org/10.2174/1574886315666200128095958

    Article  Google Scholar 

  14. Batheja P, Sheihet L, Kohn J et al (2011) Topical drug delivery by a polymeric nanosphere gel: formulation optimization and in vitro and in vivo skin distribution studies. J Control Release 149:159–167. https://doi.org/10.1016/j.jconrel.2010.10.005

    CAS  Article  Google Scholar 

  15. Beber TC, De Andrade DF, Dos Santos CP et al (2016) Cationic polymeric nanocapsules as a strategy to target dexamethasone to viable epidermis: skin penetration and permeation studies. J Nanosci Nanotechnol 16:1331–1338. https://doi.org/10.1166/jnn.2016.11670

    CAS  Article  Google Scholar 

  16. Bennet D, Kim S (2013) A transdermal delivery system to enhance quercetin nanoparticle permeability. J Biomater Sci Polym Ed 24:185–209. https://doi.org/10.1163/156856212X630258

    CAS  Article  Google Scholar 

  17. Borowska K, Wołowiec S, Rubaj A et al (2012) Effect of polyamidoamine dendrimer G3 and G4 on skin permeation of 8-methoxypsoralene–in vivo study. Int J Pharm 426:280–283. https://doi.org/10.1016/j.ijpharm.2012.01.041

    CAS  Article  Google Scholar 

  18. Cai XJ, Mesquida P, Jones SA (2016) Investigating the ability of nanoparticle-loaded hydroxypropyl methylcellulose and xanthan gum gels to enhance drug penetration into the skin. Int J Pharm 513:302–308. https://doi.org/10.1016/j.ijpharm.2016.08.055

    CAS  Article  Google Scholar 

  19. Calzoni E, Cesaretti A, Polchi A et al (2019) Biocompatible polymer nanoparticles for drug delivery applications in cancer and neurodegenerative disorder therapies. J Funct Biomater. https://doi.org/10.3390/jfb10010004

    Article  Google Scholar 

  20. Chan TC, Hawkes JE, Krueger JG (2018) Interleukin 23 in the skin: role in psoriasis pathogenesis and selective interleukin 23 blockade as treatment. Ther Adv Chronic Dis 9:111–119. https://doi.org/10.1177/2040622318759282

    CAS  Article  Google Scholar 

  21. Chandrashekara S (2012) The treatment strategies of autoimmune disease may need a different approach from conventional protocol: a review. Indian J Pharmacol 44:665–671. https://doi.org/10.4103/0253-7613.103235

    CAS  Article  Google Scholar 

  22. Chenthamara D, Subramaniam S, Ramakrishnan SG et al (2019) Therapeutic efficacy of nanoparticles and routes of administration. Biomater Res 23:20. https://doi.org/10.1186/s40824-019-0166-x

    CAS  Article  Google Scholar 

  23. Collado-González M, Montalbán MG, Peña-García J et al (2017) Chitosan as stabilizing agent for negatively charged nanoparticles. Carbohydr Polym 161:63–70. https://doi.org/10.1016/J.CARBPOL.2016.12.043

    Article  Google Scholar 

  24. Damiani G, Pacifico A, Linder D et al (2019) Nanodermatology-based solutions for psoriasis: state-of-the art and future prospects. Dermatol Ther. https://doi.org/10.1111/dth.13113

    Article  Google Scholar 

  25. Danhier F, Ansorena E, Silva JM et al (2012) PLGA-based nanoparticles: an overview of biomedical applications. J Control Release 161:505–522

    CAS  Article  Google Scholar 

  26. Dayal S, Kaura R, Sahu P, Jain VK (2018) Tazarotene gel with narrow-band UVB phototherapy: a synergistic combination in psoriasis. An Bras Dermatol 93:385–390. https://doi.org/10.1590/abd1806-4841.20186723

    Article  Google Scholar 

  27. De CV, Sutera FM, Giannola LI (2017) In situ delivery of corticosteroids for treatment of oral diseases. Ther Deliv 8:899–914

    Article  Google Scholar 

  28. de Britto D, Campana-Filho SP (2007) Kinetics of the thermal degradation of chitosan. Thermochim Acta 465:73–82. https://doi.org/10.1016/j.tca.2007.09.008

    CAS  Article  Google Scholar 

  29. de Britto D, Celi Goy R, Campana Filho SP, Assis OBG (2011) Quaternary salts of chitosan: history, antimicrobial features, and prospects. Int J Carbohydr Chem 2011:1–12. https://doi.org/10.1155/2011/312539

    CAS  Article  Google Scholar 

  30. Desai PR, Marepally S, Patel AR et al (2013) Topical delivery of anti-TNFα siRNA and capsaicin via novel lipid-polymer hybrid nanoparticles efficiently inhibits skin inflammation in vivo. J Control Release 170:51–63. https://doi.org/10.1016/j.jconrel.2013.04.021

    CAS  Article  Google Scholar 

  31. Dhaneshwar SS, Kandpal M, Gairola N, Kadam SS (2006) Dextran: a promising macromolecular drug carrier. Indian J Pharm Sci 68:705–714

    CAS  Article  Google Scholar 

  32. Di Meglio P, Villanova F, Nestle FO (2014) Psoriasis. Cold Spring Harb Perspect Med 4:a015354–a015354. https://doi.org/10.1101/cshperspect.a015354

    CAS  Article  Google Scholar 

  33. Dodane V, Amin Khan M, Merwin JR (1999) Effect of chitosan on epithelial permeability and structure. Int J Pharm 182:21–32. https://doi.org/10.1016/S0378-5173(99)00030-7

    CAS  Article  Google Scholar 

  34. Domínguez-delgado CL, Rodríguez-cruz IM, Fuentes-prado E, et al (2014) Drug Carrier Systems Using Chitosan for Non Parenteral Routes. Pharmacol Ther 273–275

  35. Elder JT, Bruce AT, Gudjonsson JE, et al (2010) Molecular Dissection of Psoriasis : Integrating Genetics and Biology. https://doi.org/10.1038/jid.2009.319

  36. Essaghraoui A, Belfkira A, Hamdaoui B et al (2019) Improved dermal delivery of cyclosporine a loaded in solid lipid nanoparticles. Nanomaterials. https://doi.org/10.3390/nano9091204

    Article  Google Scholar 

  37. Fan T, Wang S, Yu L et al (2016) Treating psoriasis by targeting its susceptibility gene. Rel Clin Immunol 165:47–54. https://doi.org/10.1016/j.clim.2016.03.009

    CAS  Article  Google Scholar 

  38. Farajzadeh R, Pilehvar-Soltanahmadi Y, Dadashpour M et al (2018) Nano-encapsulated metformin-curcumin in PLGA/PEG inhibits synergistically growth and hTERT gene expression in human breast cancer cells. Artif Cells Nanomed Biotechnol 46:917–925. https://doi.org/10.1080/21691401.2017.1347879

    CAS  Article  Google Scholar 

  39. Ferreira M, Silva E, Barreiros L et al (2016) Methotrexate loaded lipid nanoparticles for topical management of skin-related diseases: design, characterization and skin permeation potential. Int J Pharm 512:14–21. https://doi.org/10.1016/j.ijpharm.2016.08.008

    CAS  Article  Google Scholar 

  40. Ferreira M, Barreiros L, Segundo MA et al (2017) Topical co-delivery of methotrexate and etanercept using lipid nanoparticles: a targeted approach for psoriasis management. Colloids Surfaces B Biointerfaces 159:23–29. https://doi.org/10.1016/j.colsurfb.2017.07.080

    CAS  Article  Google Scholar 

  41. Gabriel D, Mugnier T, Courthion H et al (2016) Improved topical delivery of tacrolimus: a novel composite hydrogel formulation for the treatment of psoriasis. J Control Release 242:16–24. https://doi.org/10.1016/j.jconrel.2016.09.007

    CAS  Article  Google Scholar 

  42. Gaikwad DV, Yadav V, Dhavale R et al (2012) Effect of carbopol 934 and 940 on fluconazole release from topical gel formulation: a factorial approach. Curr Pharma Res 2:487–493

    Article  Google Scholar 

  43. Ghannoum MA, Long L, Isham N et al (2015) Ability of hydroxypropyl Chitosan nail lacquer to protect against dermatophyte nail infection. Antimicrob Agents Chemother 59:1844–1848. https://doi.org/10.1128/AAC.04842-14

    CAS  Article  Google Scholar 

  44. Goel A, Ahmad F, Singh R, Singh GN (2009) Anti-inflammatory activity of nanogel formulation of 3-acetyl-11-keto- β-boswellic acid. Pharmacologyonline 3:311–318

    Google Scholar 

  45. Gong J, Chen M, Zheng Y et al (2012) Polymeric micelles drug delivery system in oncology. J Control Release 159:312–323. https://doi.org/10.1016/j.jconrel.2011.12.012

    CAS  Article  Google Scholar 

  46. Gordon KB, Blauvelt A, Papp KA et al (2016) Phase 3 trials of ixekizumab in moderate-to-severe plaque psoriasis. N Engl J Med 375:345–356. https://doi.org/10.1056/NEJMoa1512711

    CAS  Article  Google Scholar 

  47. Gul A, Kunwar B, Mazhar M et al (2018) Rutin and rutin-conjugated gold nanoparticles ameliorate collagen-induced arthritis in rats through inhibition of NF-κB and iNOS activation. Int Immunopharmacol 59:310–317. https://doi.org/10.1016/j.intimp.2018.04.017

    CAS  Article  Google Scholar 

  48. Gupta S, Bansal R, Gupta S et al (2013) Nanocarriers and nanoparticles for skin care and dermatological treatments. Indian Dermatol Online J 4:267–272. https://doi.org/10.4103/2229-5178.120635

    Article  Google Scholar 

  49. Hoffman MB, Hill D, Feldman SR (2016) Current challenges and emerging drug delivery strategies for the treatment of psoriasis. Expert Opin Drug Deliv 13:1461–1473. https://doi.org/10.1080/17425247.2016.1188801

    CAS  Article  Google Scholar 

  50. Huang G, Huang H (2018) Application of dextran as nanoscale drug carriers. Nanomedicine 13:3149–3158

    CAS  Article  Google Scholar 

  51. Huang S, Huang G (2019) The dextrans as vehicles for gene and drug delivery. Future Med Chem 11:1659–1667

    CAS  Article  Google Scholar 

  52. Hussain A, Samad A, Ramzan M et al (2014a) Elastic liposome-based gel for topical delivery of 5-fluorouracil: in vitro and in vivo investigation. Drug Deliv 23:1–15. https://doi.org/10.3109/10717544.2014.976891

    CAS  Article  Google Scholar 

  53. Hussain A, Samad A, Singh S (2014b) Nanoemulsion gel-based topical delivery of an antifungal drug: in vitro activity and in vivo evaluation. Drug Deliv 21:1–16

    Article  Google Scholar 

  54. Irey EA, Lassiter CM, Brady NJ et al (2019) JAK/STAT inhibition in macrophages promotes therapeutic resistance by inducing expression of protumorigenic factors. Proc Natl Acad Sci 116:12442–12451. https://doi.org/10.1073/pnas.1816410116

    CAS  Article  Google Scholar 

  55. Ishihara T, Izumo N, Higaki M et al (2005) Role of zinc in formulation of PLGA/PLA nanoparticles encapsulating betamethasone phosphate and its release profile. J Control Release 105:68–76. https://doi.org/10.1016/j.jconrel.2005.02.026

    CAS  Article  Google Scholar 

  56. Jackson JE, Kopecki Z, Cowin AJ (2013) Nanotechnological advances in cutaneous medicine. J Nanomater 2013:808234. https://doi.org/10.1155/2013/808234

    CAS  Article  Google Scholar 

  57. Jain AK, Thareja S (2019) In vitro and in vivo characterization of pharmaceutical nanocarriers used for drug delivery. Artif Cells Nanomed Biotechnol 47:524–539. https://doi.org/10.1080/21691401.2018.1561457

    CAS  Article  Google Scholar 

  58. Jain A, Doppalapudi S, Domb AJ, Khan W (2016) Tacrolimus and curcumin co-loaded liposphere gel: Synergistic combination towards management of psoriasis. J Control Release 243:132–145. https://doi.org/10.1016/j.jconrel.2016.10.004

    CAS  Article  Google Scholar 

  59. Jijie R, Barras A, Boukherroub R, Szunerits S (2017) Nanomaterials for transdermal drug delivery: beyond the state of the art of liposomal structures. J Mater Chem B. https://doi.org/10.1039/C7TB02529G

    Article  Google Scholar 

  60. Jin Y, Zhang X, Zhang B et al (2015) Nanostructures of an amphiphilic zinc phthalocyanine polymer conjugate for photodynamic therapy of psoriasis. Colloids Surfaces B Biointerfaces 128:405–409. https://doi.org/10.1016/j.colsurfb.2015.02.038

    CAS  Article  Google Scholar 

  61. Jose C, Amra K, Bhavsar C et al (2018) Polymeric lipid hybrid nanoparticles: properties and therapeutic applications. Crit Rev Ther Drug Carrier Syst 35:555–588. https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2018024751

    Article  Google Scholar 

  62. Kamoun EA, Kenawy ERS, Chen X (2017) A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings. J Adv Res 8:217–233

    CAS  Article  Google Scholar 

  63. Kapoor DN, Dhawan S (2013) Biocompatible Nanomaterials for Targeted and Controlled Delivery of Biomacromolecules. ASME

  64. Kapoor DN, Bhatia A, Kaur R et al (2015) PLGA: A unique polymer for drug delivery. Ther Deliv 6:41–58

    CAS  Article  Google Scholar 

  65. Katare O, Raza K, Singh B, Dogra S (2010) Novel drug delivery systems in topical treatment of psoriasis: rigors and vigors. Indian J Dermatol Venereol Leprol 76:612. https://doi.org/10.4103/0378-6323.72451

    Article  Google Scholar 

  66. Kaur A, Katiyar SS, Kushwah V, Jain S (2017) Nanoemulsion loaded gel for topical co-delivery of clobitasol propionate and calcipotriol in psoriasis. Nanomed Nanotechnol Biol Med 13:1473–1482. https://doi.org/10.1016/j.nano.2017.02.009

    CAS  Article  Google Scholar 

  67. Keijsers RRMC, Hendriks AGM, Van Erp PEJ et al (2014) In vivo induction of cutaneous inflammation results in the accumulation of extracellular trap-forming neutrophils expressing RORγt and IL-17. J Invest Dermatol 134:1276–1284. https://doi.org/10.1038/jid.2013.526

    CAS  Article  Google Scholar 

  68. Khadka P, Ro J, Kim H et al (2014) Pharmaceutical particle technologies: an approach to improve drug solubility, dissolution and bioavailability. Asian J Pharm Sci 9:304–316

    Article  Google Scholar 

  69. Kilfoyle BE, Sheihet L, Zhang Z et al (2012) Development of paclitaxel-TyroSpheres for topical skin treatment. J Control Release 163:18–24. https://doi.org/10.1016/j.jconrel.2012.06.021

    CAS  Article  Google Scholar 

  70. Kim J-Y, Song J-Y, Lee E-J, Park S-K (2003) Rheological properties and microstructures of carbopol gel network system. Colloid Polym Sci 281:614–623. https://doi.org/10.1007/s00396-002-0808-7

    CAS  Article  Google Scholar 

  71. Kim JM, Kim DH, Park HJ et al (2020) Nanocomposites-based targeted oral drug delivery systems with infliximab in a murine colitis model. J Nanobiotechnology 18:133. https://doi.org/10.1186/s12951-020-00693-4

    CAS  Article  Google Scholar 

  72. Knudsen NØ, Rønholt S, Salte RD et al (2012) Calcipotriol delivery into the skin with PEGylated liposomes. Eur J Pharm Biopharm 81:532–539. https://doi.org/10.1016/j.ejpb.2012.04.005

    CAS  Article  Google Scholar 

  73. Kumari A, Yadav SK, Yadav SC (2010) Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surfaces B Biointerfaces 75:1–18. https://doi.org/10.1016/j.colsurfb.2009.09.001

    CAS  Article  Google Scholar 

  74. Kumirska J, Weinhold MX, Thöming J, Stepnowski P (2011) Biomedical activity of chitin/chitosan based materials- influence of physicochemical properties apart from molecular weight and degree of N-Acetylation. Polymers (Basel) 3:1875–1901. https://doi.org/10.3390/polym3041875

    CAS  Article  Google Scholar 

  75. Kuwabara T, Ishikawa F, Kondo M, Kakiuchi T (2017) The Role of IL-17 and Related Cytokines in Inflammatory Autoimmune Diseases. Mediators Inflamm. 2017

  76. Lakshmi PK, Devi GS, Bhaskaran S, Sacchidanand S (2007) Niosomal methotrexate gel in the treatment of localized psoriasis: Phase I and phase II studies. Indian J Dermatol Venereol Leprol 73:157–161. https://doi.org/10.4103/0378-6323.32709

    CAS  Article  Google Scholar 

  77. Lapteva M, Mondon K, Möller M et al (2014) Polymeric micelle nanocarriers for the cutaneous delivery of tacrolimus: a targeted approach for the treatment of psoriasis. Mol Pharm 11:2989–3001. https://doi.org/10.1021/mp400639e

    CAS  Article  Google Scholar 

  78. Li Y, Pei Y, Zhang X et al (2001) PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats. J Control Release 71:203–211

    CAS  Article  Google Scholar 

  79. Lima T, Bernfur K, Vilanova M, Cedervall T (2020) Understanding the lipid and protein corona formation on different sized polymeric nanoparticles. Sci Rep. https://doi.org/10.1038/s41598-020-57943-6

    Article  Google Scholar 

  80. Lombardo D, Kiselev MA, Caccamo MT (2019) Smart nanoparticles for drug delivery application: development of versatile nanocarrier platforms in biotechnology and nanomedicine. J Nanomater 2019:1–26. https://doi.org/10.1155/2019/3702518

    CAS  Article  Google Scholar 

  81. Lotfi-Attari J, Pilehvar-Soltanahmadi Y, Dadashpour M et al (2017) Co-delivery of curcumin and chrysin by polymeric nanoparticles inhibit synergistically growth and hTERT gene expression in human colorectal cancer cells. Nutr Cancer 69:1290–1299. https://doi.org/10.1080/01635581.2017.1367932

    CAS  Article  Google Scholar 

  82. Lou Y, Zhang Y, Zhu J, Tao J (2019) Dextran-based mycophenolic acid nanoparticle ameliorates imiquimod-induced psoriasis-like skin inflammation. J Invest Dermatol 139:S11. https://doi.org/10.1016/j.jid.2019.03.137

    Article  Google Scholar 

  83. Ludbrook VJ, Hicks KJ, Hanrott KE et al (2016) Investigation of selective JAK1 inhibitor GSK2586184 for the treatment of psoriasis in a randomized placebo-controlled phase IIa study. Br J Dermatol 174:985–995. https://doi.org/10.1111/bjd.14399

    CAS  Article  Google Scholar 

  84. Makadia HK, Siegel SJ (2011) Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers (Basel) 3:1377–1397. https://doi.org/10.3390/polym3031377

    CAS  Article  Google Scholar 

  85. Mao KL, Fan ZL, Yuan JD et al (2017) Skin-penetrating polymeric nanoparticles incorporated in silk fibroin hydrogel for topical delivery of curcumin to improve its therapeutic effect on psoriasis mouse model. Colloids Surfaces B Biointerfaces 160:704–714. https://doi.org/10.1016/j.colsurfb.2017.10.029

    CAS  Article  Google Scholar 

  86. Marchiori ML, Lubini G, Dalla Nora G et al (2010) Hydrogel containing dexamethasone-loaded nanocapsules for cutaneous administration: preparation, characterization, and in vitro drug release study. Drug Dev Ind Pharm 36:962–971. https://doi.org/10.3109/03639041003598960

    CAS  Article  Google Scholar 

  87. Mathew A, Fukuda T, Nagaoka Y et al (2012) Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer’s disease. PLoS ONE 7:e32616. https://doi.org/10.1371/journal.pone.0032616

    CAS  Article  Google Scholar 

  88. Maurya A, Singh AK, Mishra G et al (2019) Strategic use of nanotechnology in drug targeting and its consequences on human health: a focused review. Interv Med Appl Sci 11:38–54. https://doi.org/10.1556/1646.11.2019.04

    Article  Google Scholar 

  89. Md S, Bhattmisra SK, Zeeshan F et al (2018) Nano-carrier enabled drug delivery systems for nose to brain targeting for the treatment of neurodegenerative disorders. J Drug Deliv Sci Technol 43:295–310. https://doi.org/10.1016/j.jddst.2017.09.022

    CAS  Article  Google Scholar 

  90. Mease PJ, McInnes IB, Reich K, et al (2017) FRI0511 Secukinumab demonstrates consistent safety over long-term exposure in patients with psoriatic arthritis and moderate-to-severe plaque psoriasis: updated pooled safety analyses

  91. Milton Harris J, Chess RB (2003) Effect of pegylation on pharmaceuticals. Nat Rev Drug Discov 2:214–221

    Article  Google Scholar 

  92. Mirtič J, Papathanasiou F, Temova Rakuša Ž et al (2017) Development of medicated foams that combine incompatible hydrophilic and lipophilic drugs for psoriasis treatment. Int J Pharm 524:65–76. https://doi.org/10.1016/j.ijpharm.2017.03.061

    CAS  Article  Google Scholar 

  93. Morganti P, Ruocco E, Wolf R, Ruocco V (2001) Percutaneous absorption and delivery systems. Clin Dermatol 19:489–501. https://doi.org/10.1016/S0738-081X(01)00183-3

    CAS  Article  Google Scholar 

  94. Mourya VK, Inamdar NN (2009) Trimethyl chitosan and its applications in drug delivery. J Mater Sci Mater Med 20:1057–1079. https://doi.org/10.1007/s10856-008-3659-z

    CAS  Article  Google Scholar 

  95. Naga S, Maheshwari PV, Navya M et al (2014) Calcipotriol delivery into the skin as emulgel for effective permeation. Saudi Pharm J 22:591–599. https://doi.org/10.1016/j.jsps.2014.02.007

    Article  Google Scholar 

  96. Nemati H, Ghahramani MH, Faridi-Majidi R et al (2017) Using siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation in psoriasis. J Control Release 268:259–268. https://doi.org/10.1016/j.jconrel.2017.10.034

    CAS  Article  Google Scholar 

  97. Nguyen HX, Banga AK (2018) Electrically and ultrasonically enhanced transdermal delivery of methotrexate. Pharmaceutics. https://doi.org/10.3390/pharmaceutics10030117

    Article  Google Scholar 

  98. Ourique AF, Pohlmann AR, Guterres SS, Beck RCR (2008) Tretinoin-loaded nanocapsules: preparation, physicochemical characterization, and photostability study. Int J Pharm 352:1–4. https://doi.org/10.1016/j.ijpharm.2007.12.035

    CAS  Article  Google Scholar 

  99. Ourique AF, Melero A, BonadaSilva C et al (2011) Improved photostability and reduced skin permeation of tretinoin: development of a semisolid nanomedicine. Eur J Pharm Biopharm 79:95–101. https://doi.org/10.1016/j.ejpb.2011.03.008

    CAS  Article  Google Scholar 

  100. Palmer BC, DeLouise LA (2016) Nanoparticle-enabled transdermal drug delivery systems for enhanced dose control and tissue targeting. Molecules 21

  101. Pandey SK, Haldar C, Patel DK, Maiti P (2013) Biodegradable polymers for potential delivery systems for therapeutics. pp 169–202

  102. Panonnummal R, Sabitha M (2018) Anti-psoriatic and toxicity evaluation of methotrexate loaded chitin nanogel in imiquimod induced mice model. Int J Biol Macromol 110:245–258. https://doi.org/10.1016/j.ijbiomac.2017.10.112

    CAS  Article  Google Scholar 

  103. Papp KA, Griffiths CEM, Gordon K et al (2013) Long-term safety of ustekinumab in patients with moderate-to-severe psoriasis: final results from 5 years of follow-up. Br J Dermatol 168:844–854. https://doi.org/10.1111/bjd.12214

    CAS  Article  Google Scholar 

  104. Papp KA, Krueger JG, Feldman SR et al (2016) Tofacitinib, an oral Janus kinase inhibitor, for the treatment of chronic plaque psoriasis: long-term efficacy and safety results from 2 randomized phase-III studies and 1 open-label long-term extension study. J Am Acad Dermatol 74:841–850. https://doi.org/10.1016/j.jaad.2016.01.013

    CAS  Article  Google Scholar 

  105. Paredes KO, Alarcón DI (2019) The state of the art of investigational and approved nanomedicine products for nucleic acid delivery. Nucleic Acid Nanotheranostics. https://doi.org/10.1016/B978-0-12-814470-1.00015-0

    Article  Google Scholar 

  106. Patel S, Dwivedi SD, Yadav K, et al (2020) Pathogenesis and Molecular Targets in Treatment of Diabetic Wounds. In: Obesity and Diabetes, J. Faintuc. Springer Nature Switzerland AG 2020, pp 747–758

  107. Pinelli F, Perale G, Rossi F (2020) Coating and functionalization strategies for nanogels and nanoparticles for selective drug delivery. Gels (Basel, Switzerland). https://doi.org/10.3390/gels6010006

    Article  Google Scholar 

  108. Prabaharan M, Mano JF (2005) Chitosan-based particles as controlled drug delivery systems. Drug Deliv J Deliv Target Ther Agents 12:41–57. https://doi.org/10.1080/10717540590889781

    CAS  Article  Google Scholar 

  109. Pradhan M, Singh D, Singh MR (2013) Novel colloidal carriers for psoriasis: current issues, mechanistic insight and novel delivery approaches. J Control Release 170:380–395. https://doi.org/10.1016/j.jconrel.2013.05.020

    CAS  Article  Google Scholar 

  110. Pradhan M, Alexander A, Singh MR et al (2018) Understanding the prospective of nano-formulations towards the treatment of psoriasis. Biomed Pharmacother 107:447–463

    CAS  Article  Google Scholar 

  111. Pradhan M, Alexander A, Singh MR et al (2020) Statistically optimized calcipotriol fused nanostructured lipid carriers for effectual topical treatment of psoriasis. J Drug Deliv Sci Technol. https://doi.org/10.1016/j.jddst.2020.102168

    Article  Google Scholar 

  112. Pradhan M, Yadav K, Singh D, Singh MR (2021) Topical delivery of fluocinolone acetonide integrated NLCs and salicylic acid enriched gel: a potential and synergistic approach in the management of psoriasis. J Drug Deliv Sci Technol 61:102282. https://doi.org/10.1016/j.jddst.2020.102282

    CAS  Article  Google Scholar 

  113. Prasad V, Chaurasia S (2017) Performance evaluation of non-ionic surfactant based tazarotene encapsulated proniosomal gel for the treatment of psoriasis. Mater Sci Eng C 79:168–176. https://doi.org/10.1016/j.msec.2017.05.036

    CAS  Article  Google Scholar 

  114. Prausnitz MR, Elias PM, Franz TJ, et al (2012) Skin Barrier and Transdermal Drug Delivery. Med Ther 2065–2073

  115. Proniuk S, Blanchard J (2002) Anhydrous Carbopol polymer gels for the topical delivery of oxygen/water sensitive compounds. Pharm Dev Technol 7:249–255. https://doi.org/10.1081/pdt-120003492

    CAS  Article  Google Scholar 

  116. Prosperi D, Colombo M, Zanoni I, Granucci F (2017) Drug nanocarriers to treat autoimmunity and chronic inflammatory diseases. Semin Immunol 34:61–67

    CAS  Article  Google Scholar 

  117. Rahman M, Akhter S, Ahmad J et al (2015) Nanomedicine-based drug targeting for psoriasis: potentials and emerging trends in nanoscale pharmacotherapy. Expert Opin Drug Deliv 12:635–652. https://doi.org/10.1517/17425247.2015.982088

    CAS  Article  Google Scholar 

  118. Ramanunny AK, Wadhwa S, Singh SK et al (2020) Treatment strategies against psoriasis: principle, perspectives and practices. Curr Drug Deliv 17:52–73. https://doi.org/10.2174/1567201816666191120120551

    CAS  Article  Google Scholar 

  119. Ramezanli T, Kilfoyle BE, Zhang Z, Michniak-Kohn BB (2017) Polymeric nanospheres for topical delivery of vitamin D3. Int J Pharm 516:196–203. https://doi.org/10.1016/j.ijpharm.2016.10.072

    CAS  Article  Google Scholar 

  120. Raza K, Singh B, Lohan S et al (2013) Nano-lipoidal carriers of tretinoin with enhanced percutaneous absorption, photostability, biocompatibility and anti-psoriatic activity. Int J Pharm 456:65–72. https://doi.org/10.1016/j.ijpharm.2013.08.019

    CAS  Article  Google Scholar 

  121. Ridolfi DM, Marcato PD, Justo GZ et al (2012) Chitosan-solid lipid nanoparticles as carriers for topical delivery of tretinoin. Colloids Surfaces B Biointerfaces 93:36–40. https://doi.org/10.1016/j.colsurfb.2011.11.051

    CAS  Article  Google Scholar 

  122. Roberts MS, Mohammed Y, Pastore MN et al (2017) Topical and cutaneous delivery using nanosystems. J Control Release 247:86–105

    CAS  Article  Google Scholar 

  123. Rønholt K, Iversen L (2017) Old and new biological therapies for psoriasis. Int J Mol Sci 18:2297. https://doi.org/10.3390/ijms18112297

    CAS  Article  Google Scholar 

  124. Rosado C, Silva C, Reis CP (2013) Hydrocortisone-loaded poly(ε-caprolactone) nanoparticles for atopic dermatitis treatment. Pharm Dev Technol 18:710–718. https://doi.org/10.3109/10837450.2012.712537

    CAS  Article  Google Scholar 

  125. Sala M, Diab R, Elaissari A, Fessi H (2018) Lipid nanocarriers as skin drug delivery systems: properties, mechanisms of skin interactions and medical applications. Int J Pharm 535:1–17

    CAS  Article  Google Scholar 

  126. Saleem S, Iqubal MK, Garg S et al (2020) Trends in nanotechnology-based delivery systems for dermal targeting of drugs: an enticing approach to offset psoriasis. Expert Opin Drug Deliv. https://doi.org/10.1080/17425247.2020.1758665

    Article  Google Scholar 

  127. Schipper NG, Vârum KM, Stenberg P et al (1999) Chitosans as absorption enhancers of poorly absorbable drugs. 3: influence of mucus on absorption enhancement. Eur J Pharm Sci 8:335–343. https://doi.org/10.1016/s0928-0987(99)00032-9

    CAS  Article  Google Scholar 

  128. Şenyiğit T, Sonvico F, Barbieri S et al (2010) Lecithin/chitosan nanoparticles of clobetasol-17-propionate capable of accumulation in pig skin. J Control Release 142:368–373. https://doi.org/10.1016/j.jconrel.2009.11.013

    CAS  Article  Google Scholar 

  129. Shah PP, Desai PR, Patel AR, Singh MS (2012) Skin permeating nanogel for the cutaneous co-delivery of two anti-inflammatory drugs. Biomaterials 33:1607–1617. https://doi.org/10.1016/j.biomaterials.2011.11.011

    CAS  Article  Google Scholar 

  130. Shah PP, Desai PR, Boakye CHA et al (2016) Percutaneous delivery of α -melanocyte-stimulating hormone for the treatment of imiquimod-induced psoriasis. J Drug Target 24:537–547. https://doi.org/10.3109/1061186X.2015.1103743

    CAS  Article  Google Scholar 

  131. Siepmann J (2001) Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug Deliv Rev 48:139–157. https://doi.org/10.1016/S0169-409X(01)00112-0

    CAS  Article  Google Scholar 

  132. Singh A, Thotakura N, Kumar R et al (2017) PLGA-soya lecithin based micelles for enhanced delivery of methotrexate: cellular uptake, cytotoxic and pharmacokinetic evidences. Int J Biol Macromol 95:750–756. https://doi.org/10.1016/j.ijbiomac.2016.11.111

    CAS  Article  Google Scholar 

  133. Singka GSLL, Samah NA, Zulfakar MH et al (2010) Enhanced topical delivery and anti-inflammatory activity of methotrexate from an activated nanogel. Eur J Pharm Biopharm 76:275–281. https://doi.org/10.1016/j.ejpb.2010.06.014

    CAS  Article  Google Scholar 

  134. Sivaram AJ, Rajitha P, Maya S et al (2015) Nanogels for delivery, imaging and therapy. Wiley Interdiscip Rev Nanomed Nanobiotechnol 7:509–533. https://doi.org/10.1002/wnan.1328

    CAS  Article  Google Scholar 

  135. Srisuk P, Thongnopnua P, Raktanonchai U, Kanokpanont S (2012) Physico-chemical characteristics of methotrexate-entrapped oleic acid-containing deformable liposomes for in vitro transepidermal delivery targeting psoriasis treatment. Int J Pharm 427:426–434. https://doi.org/10.1016/j.ijpharm.2012.01.045

    CAS  Article  Google Scholar 

  136. Suk JS, Xu Q, Kim N et al (2016) PEGylation as a strategy for improving nanoparticle-based drug and gene delivery. Adv Drug Deliv Rev 99:28–51. https://doi.org/10.1016/j.addr.2015.09.012

    CAS  Article  Google Scholar 

  137. Sumit S, Shikha L, Murthy RSR (2012) Potential of chitosan for nose to brain drug delivery. Int J Pharm Sci Rev Res 16:47–55

    Google Scholar 

  138. Sun L, Liu Z, Wang L et al (2017) Enhanced topical penetration, system exposure and anti-psoriasis activity of two particle-sized, curcumin-loaded PLGA nanoparticles in hydrogel. J Control Release 254:44–54. https://doi.org/10.1016/J.JCONREL.2017.03.385

    CAS  Article  Google Scholar 

  139. Talele S, Nikam P, Ghosh B et al (2017) A research article on nanogel as topical promising drug delivery for diclofenac sodium. Indian J Pharm Educ Res 51:s580–s587. https://doi.org/10.5530/ijper.51.4s.86

    CAS  Article  Google Scholar 

  140. Tanghetti EA, Stein Gold L, Del Rosso JQ et al (2019) Optimized formulation for topical application of a fixed combination halobetasol/tazarotene lotion using polymeric emulsion technology. J Dermatolog Treat. https://doi.org/10.1080/09546634.2019.1668907

    Article  Google Scholar 

  141. Thanou M, Verhoef JC, Junginger HE (2001) Chitosan and its derivatives as intestinal absorption enhancers. Adv Drug Deliv Rev 50(Suppl 1):S91-101. https://doi.org/10.1016/s0169-409x(01)00180-6

    CAS  Article  Google Scholar 

  142. Tomoda K, Watanabe A, Suzuki K et al (2012) Enhanced transdermal permeability of estradiol using combination of PLGA nanoparticles system and iontophoresis. Colloids Surfaces B Biointerfaces 97:84–89. https://doi.org/10.1016/j.colsurfb.2012.04.002

    CAS  Article  Google Scholar 

  143. Tonel G, Conrad C, Laggner U et al (2010) Cutting edge: a critical functional role for IL-23 in psoriasis. J Immunol 185:5688–5691. https://doi.org/10.4049/jimmunol.1001538

    CAS  Article  Google Scholar 

  144. Urdaneta M, Jethwa H, Sultan R, Abraham S (2017) A review on golimumab in the treatment of psoriatic arthritis. Immunotherapy 9:871–889. https://doi.org/10.2217/imt-2017-0063

    CAS  Article  Google Scholar 

  145. Venditti I (2019) Morphologies and functionalities of polymeric nanocarriers as chemical tools for drug delivery: a review. J King Saud Univ - Sci 31:398–411

    Article  Google Scholar 

  146. Veronese FM, Pasut G (2005) PEGylation, successful approach to drug delivery. Drug Discov Today 10:1451–1458

    CAS  Article  Google Scholar 

  147. Vlaia L, Coneac G, Olariu I et al (2016) Cellulose-Derivatives-Based Hydrogels as Vehicles for Dermal and Transdermal Drug Delivery. In: Emerging Concepts in Analysis and Applications of Hydrogels. InTech

  148. Vyas SP, Rawat M, Rawat A et al (2006) Pegylated protein encapsulated multivesicular liposomes: a novel approach for sustained release of interferon α. Drug Dev Ind Pharm 32:699–707. https://doi.org/10.1080/03639040500528954

    CAS  Article  Google Scholar 

  149. Wan T, Pan J, Long Y et al (2017) Dual roles of TPGS based microemulsion for tacrolimus: enhancing the percutaneous delivery and anti-psoriatic efficacy. Int J Pharm 528:511–523. https://doi.org/10.1016/j.ijpharm.2017.06.050

    CAS  Article  Google Scholar 

  150. Wang L-Y, Jelle M, Yang D-P (2008) Preparations of psoralen-loaded PLGA nanoparticles and its characteristics of penetration across human skin. Chine Pharm J 43:1317+1318–1321

  151. Wang H, Syrovets T, Kess D et al (2009) Targeting NF-kappa B with a natural triterpenoid alleviates skin inflammation in a mouse model of psoriasis. J Immunol 183:4755–4763. https://doi.org/10.4049/jimmunol.0900521

    CAS  Article  Google Scholar 

  152. Wang Y, Wang C, Fu S et al (2011) Preparation of Tacrolimus loaded micelles based on poly(ɛ-caprolactone)-poly(ethylene glycol)-poly(ɛ-caprolactone). Int J Pharm 407:184–189. https://doi.org/10.1016/j.ijpharm.2011.01.018

    CAS  Article  Google Scholar 

  153. Yadav K, Singh D, Singh MRMRMR (2018b) Protein biomarker for psoriasis: a systematic review on their role in the pathomechanism, diagnosis, potential targets and treatment of psoriasis. Int J Biol Macromol 118:1796–1810. https://doi.org/10.1016/j.ijbiomac.2018.07.021

    CAS  Article  Google Scholar 

  154. Yadav K, Pawar J, Singh D, Singh MR (2018a) Promising phytoactives candidates for efficacious treatment of psoriasis and other skin disorders. J Ravishankar Univ (Part-B; Sci 31:10–22

  155. Yadav K, Singh D, Singh MR, Pradhan M (2020) Multifaceted targeting of cationic liposomes via co-delivery of anti-IL-17 siRNA and corticosteroid for topical treatment of psoriasis. Med Hypotheses 145:110322. https://doi.org/10.1016/j.mehy.2020.110322

    CAS  Article  Google Scholar 

  156. Yadav K, Chauhan NS, Saraf S, et al (2020a) Challenges and need of delivery carriers for bioactives and biological agents: an introduction. In: Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents. Elsevier, pp 1–36

  157. Yadav K, Singh MR, Rai VK, et al (2020c) Commercial aspects and market potential of novel delivery systems for bioactives and biological agents. In: Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents. Elsevier, pp 595–620

  158. Yang L, Zhang CS, May B et al (2015) Efficacy of combining oral Chinese herbal medicine and NB-UVB in treating psoriasis vulgaris: a systematic review and meta-analysis. Chin Med 10:27. https://doi.org/10.1186/s13020-015-0060-y

    CAS  Article  Google Scholar 

  159. Yu K, Wang Y, Wan T et al (2018) Tacrolimus nanoparticles based on chitosan combined with nicotinamide: enhancing percutaneous delivery and treatment efficacy for atopic dermatitis and reducing dose. Int J Nanomed 13:129–142. https://doi.org/10.2147/IJN.S150319

    CAS  Article  Google Scholar 

  160. Zhang X, Zhang T, Ma X et al (2020) The design and synthesis of dextran-doxorubicin prodrug-based pH-sensitive drug delivery system for improving chemotherapy efficacy. Asian J Pharm Sci. https://doi.org/10.1016/j.ajps.2019.10.001

    Article  Google Scholar 

  161. Zhao J, Zhang Z, Xue Y et al (2018) Anti-tumor macrophages activated by ferumoxytol combined or surface-functionalized with the TLR3 agonist poly (I: C) promote melanoma regression. Theranostics 8:6307–6321. https://doi.org/10.7150/thno.29746

    CAS  Article  Google Scholar 

  162. Zielińska A, Costa B, Ferreira MV et al (2020) Nanotoxicology and nanosafety: safety-by-design and testing at a glance. Int J Environ Res Public Health. https://doi.org/10.3390/ijerph17134657

    Article  Google Scholar 

  163. Zielińska A, Carreiró F, Oliveira AM et al (2020) Polymeric nanoparticles: production, characterization. Toxicol Ecotoxicol Mol. https://doi.org/10.3390/molecules25163731

    Article  Google Scholar 

  164. Zuchi MF, Azevedo P de O, Tanaka AA, et al (2015) Serum levels of 25-hydroxy vitamin D in psoriatic patients. An Bras Dermatol 90:430–432. https://doi.org/10.1590/abd1806-4841.20153524

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The authors would like to mention DHR-ICMR (FN.V.25011/286-HRD/2016-HR) for financial support.

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  1. University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh, 492010, India

    Krishna Yadav, Akanksha Soni, Deependra Singh & Manju Rawat Singh

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  1. Krishna Yadav
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Yadav, K., Soni, A., Singh, D. et al. Polymers in topical delivery of anti-psoriatic medications and other topical agents in overcoming the barriers of conventional treatment strategies. Prog Biomater 10, 1–17 (2021). https://doi.org/10.1007/s40204-021-00154-7

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Keywords

  • Psoriasis
  • Hyperkeratosis
  • Inflammation
  • Polymeric carrier
  • Immune-mediated skin disorder