In Silico Pharmacology

, 6:7 | Cite as

lncRNA-based study of epigenetic regulations in diabetic peripheral neuropathy

  • Muhamad Fachrul
  • Didik H. Utomo
  • Arli A. Parikesit
Original Research


Diabetes remains one of the most prevalent non-communicable diseases in the world, affecting over 400 million of people worldwide, causing serious complications leading to amputations and even death. Over the years, researchers have found that, in addition to genomic mutations, epigenetic mechanisms also play a role in the development of diabetes-specifically type-2 diabetes. Long noncoding RNAs (lncRNAs) have been linked to mediate epigenetic mechanisms, including those in late-stage diabetes. This study attempts to assess the unexplored topic of how lncRNAs could be used to assess the epigenetic mechanisms present in diabetic peripheral neuropathy (DPN); a serious complication of the disease often leading to amputation. Differential lncRNA expression analysis was done with a dataset containing DPN and healthy patients. Standard and corrected t test, and also LIMMA was applied. Results of this study indicates the usefulness of lncRNAs as an exploratory tool to elucidate the complexity of the epigenetic mechanisms of human DPN.


Epigenetic lncRNA In Silico Type-2 diabetes 



Authors thanks to Indonesia International Institute for Life Sciences for facilitated this research.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Muhamad Fachrul
    • 1
  • Didik H. Utomo
    • 2
    • 3
  • Arli A. Parikesit
    • 1
  1. 1.Bioinformatics Department, School of Life SciencesIndonesia International Institute for Life SciencesJakartaIndonesia
  2. 2.Biology Department, Faculty of SciencesBrawijaya UniversityMalangIndonesia
  3. 3.Research and Education Center for BioinformaticsNusantara Institute for Life Science and TechnologyJakartaIndonesia

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