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Air pollution and exacerbation of skin itching and sleep disturbance in Iranian atopic dermatitis patients

  • Pegah Nakhjirgan
  • Masoumeh Mahmoodi
  • Homa KashaniEmail author
  • Alireza Firooz
  • Ramin Nabizadeh
  • Majid Kermani
  • Masud YunesianEmail author
Research article
  • 56 Downloads

Abstract

Background

For about three decades now, the number of people suffering from atopy including atopic dermatitis (AD) has been increasing in developed countries. Genetic background and environmental factors including air pollution play an effective role in its incidence. This study examined the association between air pollutants and exacerbation of AD symptoms including sleep disturbance and itching in AD patients of Tehran.

Methods

In this panel study, 31 patients with AD who admitted to Razi Hospital, dermatology hospital in Tehran, entered the research. Daily information including questions on disease symptoms (sleep disturbance, itching) and duration of outdoor stay (in hours) were collected using a questionnaire. The mean 24-h concentrations of PM2.5 and PM10 pollutants were obtained from the Air Quality Control Company. The relationship between the concentrations of the pollutants and exacerbation of the disease symptoms was investigated using the GEE (Generalized Estimating Equations) model.

Results

There was a significant relationship between the concentrations of air pollutants and exacerbation of sleep disturbance and itching on the same day, before, and after adjusting the effects of the confounding variables, so that the estimated odds ratios (95% confidence interval) between PM10 and PM2.5 and exacerbation of itching were 1.06 (1.02–1.10) and 1.17 (1.07–1.28), respectively.

Conclusions

There was a significant statistical relationship between the concentration of particulate matter (PM2.5 and PM10) and exacerbation of sleep disturbance and itching. PM2.5 showed a stronger relationship with the exacerbation of symptoms compared to PM10.

Keywords

Air pollution Atopic dermatitis Particulate matter Itching Sleep disturbance 

Abbreviations

AD

atopic dermatitis

CIs

Confidence intervals

GEE

Generalized Estimating Equations

NCDC

National Climatic Data Center

ORs

Odds ratios

PM2.5

Particulate matter ≤2.5 μm in aerodynamic diameter

PM10

Particulate matter ≤10 μm in aerodynamic diameter

SCORAD

Scoring Atopic Dermatitis

SD

Standard deviation

Notes

Acknowledgments

This research was financially supported by the Institute for Environmental Research (IER) of Tehran University of Medical Sciences (grant number 92-01-46-22328). We thank all the patients who participated in this research, and the Razi hospital staffs for their cooperation.

Compliance with ethical standards

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Pegah Nakhjirgan
    • 1
  • Masoumeh Mahmoodi
    • 1
  • Homa Kashani
    • 2
    Email author
  • Alireza Firooz
    • 3
  • Ramin Nabizadeh
    • 1
  • Majid Kermani
    • 4
  • Masud Yunesian
    • 1
    • 5
    Email author
  1. 1.Department of Environmental Health Engineering, School of Public HealthTehran University of Medical SciencesTehranIran
  2. 2.Department of Research Methodology and Data Analysis, Institute for Environmental ResearchTehran University of Medical SciencesTehranIran
  3. 3.Center for Research and Training in Skin Diseases and LeprosyTehran University of Medical SciencesTehranIran
  4. 4.Department of Environmental Health Engineering, School of Public HealthIran University of Medical SciencesTehranIran
  5. 5.Center for Air Pollution Research, Institute for Environmental ResearchTehran University of Medical SciencesTehranIran

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