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Inflammation and immunological disarrays are associated with acute exercise in type 2 diabetes

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Abstract

Objective

Type 2 diabetes (T2D) is the most common metabolic disorder that is associated with insulin resistance. The aim of the present study is to discover details of the molecular mechanism of exercise on control or progress of diabetic condition in patients via network analysis.

Methods

Gene expression profiles of patients with T2D before and after doing exercise are retrieved from Gene Expression Omnibus (GEO) and are pre-evaluated by the GEO2R program. Data are studied based on expression values, regulatory relationships between the differentially expressed genes (DEGs), gene ontology analyses, and protein-protein interaction PPI network analysis.

Results

A number of 118 significant DEGs were identified and classified based on fold change (FC) values as most dysregulated genes and dysregulated individuals. Action map analysis revealed that 18 DEGs appeared as the critical genes. Gene ontology analysis showed that 24 DEGs are connected to at least four pathways. JUN, IL6, IL1B, PTGS2, FOS, MYC, ATF3, CXCL8, EGR1, EGR2, NR4A1, PLK3, TTN, and UCP3 were identified as central DEGs.

Conclusion

Finally; JUN, IL6, IL1B, PTGS2, FOS, ATF3, CXCL8, EGR1, and EGR2 were introduced as the critical targeted genes by exercise. Since the critical genes after exercise are upregulated and mostly are known as the risk factors of T2D, it can be concluded that unsuitable exercise can develop diabetic conditions in patients. Acute exercise-induced inflammation and immune disturbances seem to be associated with the development of T2D in patients.

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Acknowledgements

This project is supported by Shahid Beheshti University of Medical Sciences.

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Authors and Affiliations

  1. Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Vahid Mansouri, Parisa Sarabi & Mostafa Rezaei-Tavirani

  2. Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Reza Vafaee

  3. Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mahsa Mohammadi Maram & Hassan Karimi

  4. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Fatemeh Bandarian

  5. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Farideh Razi

  6. Laser application in medical sciences research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Zahra Razzaghi

  7. Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Majid Rezaei Tavirani

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  1. Vahid Mansouri
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Correspondence to Mostafa Rezaei-Tavirani.

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Mansouri, V., Vafaee, R., Mohammadi Maram, M. et al. Inflammation and immunological disarrays are associated with acute exercise in type 2 diabetes. J Diabetes Metab Disord (2024). https://doi.org/10.1007/s40200-024-01417-3

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