Abstract
This case report presents a 9-year-old child without underlying pathology, with a severe life-threatening non-diabetic metabolic ketoacidosis occurring less than 48 h after the onset of fasting and vomiting. The patient was admitted to the pediatric intensive care unit. He received volume expansion and maintenance fluid therapy which allowed a favorable evolution. Because of the unusual rapid onset of intense ketonemia and acidosis, a hereditary metabolic disease was investigated. The association between short fasting period and severe metabolic ketoacidosis has never been described in children outside of the neonatal period. This clinical case emphasizes urgent recognition, rigorous diagnostic and appropriate management in clinical practice.
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Abbreviations
- AG:
-
Anion Gap
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Dr C.R conceptualized and designed the study, drafted the initial manuscript, and critically reviewed and revised the manuscript. Drs C.F, C.A, C.L, A.A and I.G collected data, carried out the initial analyses, and critically reviewed and revised the manuscript. Dr D.B conceptualized and designed the study, coordinated and supervised data collection, and critically reviewed and revised the manuscript for important intellectual content. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.
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Roulland, C., Le Pallec, C., Faucon, C. et al. A severe pediatric life-threatening metabolic ketoacidosis. J Diabetes Metab Disord (2024). https://doi.org/10.1007/s40200-024-01410-w
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DOI: https://doi.org/10.1007/s40200-024-01410-w