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The global prevalence of sexual dysfunction in men with thyroid gland disorders: a systematic review and meta-analysis

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Abstract

Introduction

fluctuation in serum levels of thyroid hormones or thyroid-associated dysfunction can negatively affect the sexual behaviors or performance, and disruption in couples` relationship or satisfaction. Thus, this systematic review and meta-analysis study was aimed to investigate the global prevalence of sexual dysfunction in men with thyroid gland disorders (TGD).

Methods

this systematic review and meta-analysis study conducted based on PRISMA statement criteria regarding the available evidences representing the prevalence of sexual dysfunction in men with TGD. The initial searching process was applied on July, 2023. In this era, the main keywords of “Prevalence”, “Sexual disorders”, “Sexual disorder”, “Sexual dysfunction”, “Male sexual dysfunction”, “Erectile dysfunction”, “Males”, “Men”, “Thyroid disorders”, “Thyroid diseases”, “Hyperthyroidism”, “Thyroid”, and “Thyroiditis” were hired. Also, “AND” and “OR” operators were used for keywords combination. All intended studies were searched using the databases of Web of Science, Google Scholar, Scopus, ScienceDirect, PubMed, and Embase. Random effects model was used to perform the analysis and the heterogeneity of the studies was assessed through I2 index. Data analysis was applied with CMA software (v.2).

Results

following the assessment of 17 eligible studies with a sample size of 501 individuals, the global prevalence of male sexual dysfunction with TGD was found 51.5% (95% CI:38.7–64). Also, the prevalence of male sexual dysfunction in hypothyroidism and hyperthyroidism cases was 59.1% (95% CI:37.2–77.8) and 41.5% (95% CI:25.9–59.1), respectively. The meta-regression analysis showed that following incremental trend in sample size, the global prevalence of male sexual dysfunction with TGD decreases. This assessment also revealed that the prevalence of male sexual dysfunction increases with the year of study conduction, significantly (p < 0.05).

Conclusion

the global prevalence of sexual dysfunction in men with TGD was found relatively high. also, the highest prevalence of sexual disorders was reported in hypothyroid cases. Thus, health policymakers are suggested to inform the individuals prone to this pathology regarding the negative effects of TGD on sexual dysfunction. Besides, TGD-affected cases can prevent sexual disorders and unpleasant consequences through timely medical treatments.

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Data availability

Datasets are available through the corresponding author upon reasonable request.

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Acknowledgements

By Student Research Committee of Kermanshah University of Medical Sciences.

Funding

ByDeputy for Research and Technology, Kermanshah University of Medical Sciences (IR)(4020665). This deputy has no role in the study process.

Author information

Authors and Affiliations

  1. Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Nader Salari

  2. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Negin Fattahi

  3. Department of Operating Room, Nahavand School of Allied Medical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran

    Amir Abdolmaleki

  4. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Pegah Heidarian

  5. Department of Biology, Faculty of Science, University Putra Malaysia, Serdang, Selangor, Malaysia

    Shamarina Shohaimi

  6. Cellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash, Iran

    Masoud Mohammadi

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Contributions

NS and PH and NF and MM contributed to the design, MM statistical analysis, and participated in most of the study steps. MM and NF and PH and AA and SS prepared the manuscript. All authors have read and approved the content of the manuscript.

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Correspondence to Masoud Mohammadi.

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Ethics approval was received from the ethics committee of deputy of research and technology, Kermanshah University of Medical Sciences (IR.KUMS.REC.1402.373).

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Salari, N., Fattahi, N., Abdolmaleki, A. et al. The global prevalence of sexual dysfunction in men with thyroid gland disorders: a systematic review and meta-analysis. J Diabetes Metab Disord (2024). https://doi.org/10.1007/s40200-024-01408-4

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