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Exploring the metabolomics profile of frailty- a systematic review

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Abstract

Background

Frailty is a multifaceted geriatric syndrome characterized by an increased vulnerability to stressful events. metabolomics studies are valuable tool for better understanding the underlying mechanisms of pathologic conditions. This review aimed to elucidate the metabolomics profile of frailty.

Method

This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) 2020 statement. A comprehensive search was conducted across multiple databases. Initially, 5027 results were retrieved, and after removing duplicates, 1838 unique studies were subjected to screening. Subsequently, 248 studies underwent full-text screening, with 21 studies ultimately included in the analysis. Data extraction was performed meticulously by two authors, and the quality of the selected studies was assessed using the Critical Appraisal Skills Program (CASP) checklist.

Results

The findings revealed that certain Branched-chain amino acids (BCAAs) levels were lower in frail subjects compared to robust subjects, while levels of glutamate and glutamine were higher in frail individuals. Moreover, sphingomyelins and phosphatidylcholines (PC) displayed a decreasing trend as frailty advanced. Additionally, other metabolic derivatives, such as carnitine, exhibited significant associations with frailty. These metabolites were primarily interconnected through biochemical pathways related to the tricarboxylic acid and urea cycles. Notably, frailty was associated with a decrease in metabolic derivatives, including carnitine.

Conclusion

This study underscores the intricate relationship between essential metabolites, including amino acids and lipids, and their varying levels in frail individuals compared to their robust counterparts. It provides a comprehensive panel of metabolites, shedding light on their potential associations with frailty and expanding our understanding of this complex syndrome.

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Data availability

The datasets generated during and analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

This systematic review was carried out without the provision of external financial support or research grants.

Author information

Author notes

  1. Ahmadreza Shekarchian and Fatemeh Bandarian contributed equally to this work.

Authors and Affiliations

  1. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular- Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Ahmadreza Shekarchian

  2. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Fatemeh Bandarian

  3. Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

    Alireza Hadizadeh, Aryan Ayati & Mahbube Ebrahimpur

  4. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Zahra Amirsardari

  5. Department of Radiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Yasaman Sharifi

  6. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran university of medical sciences, Tehran, Iran

    Yasaman Sharifi & Bagher Larijani

  7. Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Mehdi Varmaghani

  8. School of Pharmacy, Mashhad University of Medical Science, Mashhad, Iran

    Ashkan Fatemi Shandiz

  9. Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Farshad Sharifi

  10. Department of Radiology, Advanced Diagnostic, and Interventional Radiology Research Center (ADIR), Tehran, Iran

    Abdolkarim Haji Ghadery & Mahbube Ebrahimpur

  11. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Akram Tayanloo

  12. Department of Internal Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Tahereh Yavari

  13. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Moloud Payab

  14. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Mahbube Ebrahimpur

  15. EMRI (Endocrinology and Metabolism Research Institute), First Floor, No 10, Jalal-Al-Ahmad Street, North Kargar Avenue, Tehran, 14117-13137, Iran

    Moloud Payab & Mahbube Ebrahimpur

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  1. Ahmadreza Shekarchian
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Contributions

Conceptualization: MP, ME, BL

Supervision: MP, BL, ME

Search and Review: AS, YS, MV, AG, TY, FS

Manuscript Writing: ASH, AH, YS, ZA

Revision and Editing: AA, ASH, ZA

Figure: ASH, AA

All authors reviewed and approved the final version of the manuscript

Corresponding authors

Correspondence to Moloud Payab or Mahbube Ebrahimpur.

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The ethical committee of EMRI approved the present study (IR.TUMS.EMRI.REC.1399.060)

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Shekarchian, A., Bandarian, F., Hadizadeh, A. et al. Exploring the metabolomics profile of frailty- a systematic review. J Diabetes Metab Disord 23, 289–303 (2024). https://doi.org/10.1007/s40200-023-01379-y

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