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Association of vaspin rs2236242 with type 2 diabetes mellitus and obesity: a meta-analysis of case-control studies

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Elevated circulating vaspin levels is linked with type 2 diabetes mellitus (T2DM) and obesity. The genetic basis of the association between vaspin rs2236242 and T2DM and obesity is still being investigated. We executed a meta-analysis to evaluate the magnitude of effect caused by vaspin rs2236242 on T2DM and obesity.


We searched Pubmed, Embase, MEDLINE, Scopus, Web of Science, and Google Scholar for relevant articles published up to 19 February 2022. Data were extracted and summary estimates of the association between vaspin rs2236242 and T2DM and obesity were assessed. Odds ratios (ORs) and confidence intervals (CIs) were used to measure the effect.


This meta-analysis included 2206 cases and 2715 controls in the T2DM cohort, meanwhile 271 cases and 444 controls in the obesity cohort. The pooled estimates revealed no link between vaspin rs2236242 and T2DM, but allele-A was significantly higher in the controls of the obesity cohort, showing that this single nucleotide polymorphism (SNP) has a reduced obesity risk effect. Sensitivity analysis revealed no studies that would modify the estimates or the heterogeneity. Begg and Mazumdar’s and Egger’s tests indicated no substantial publication bias.


Our meta-analysis provides evidence of significant association between vaspin rs2236242 and reduced risk of obesity but not T2DM.

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The authors wish to thank Sareh Kamran at the Department of Pharmacology, Faculty of Medicine, Universiti Malaya for her assistance in interpreting an article by Zarei et al.

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SMZ and YFP performed the literature search and data extraction. SMZ performed the data analysis. SMZ and YFP participated in the data interpretation and the writing of the manuscript. RM revised the article for important intellectual content. All authors read and approved the final manuscript.

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Correspondence to S. M. Zain.

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Zain, S.M., Pung, Y.F. & Mohamed, R. Association of vaspin rs2236242 with type 2 diabetes mellitus and obesity: a meta-analysis of case-control studies. J Diabetes Metab Disord 22, 237–243 (2023).

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