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RETRACTED ARTICLE: Systematisation of biological protectors for managing the metabolic syndrome development

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This article was retracted on 30 May 2023

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Abstract

Background

Metabolic syndrome (MS) is becoming a major health risk in the world. Disorders of homeostasis are a trigger for MS and subsequent cardiometabolic diseases (CMDs). Its physiological role can be supported by biological protectors (BP). The purpose of this study is to develop a BP system for managing the MS development.

Methods

Within the framework of the case-control study, 3000 participants aged 20–60 years formed 2 groups: the main group and the control group.

Results

The study compared traditional markers of oxidative stress, chronic inflammation, and insulin resistance, which reflect the state of homeostasis. The BP system, proposed based on the concept of maintaining homeostasis, offers the following points for investigating the possibilities of therapeutic intervention: confronting dysregulation of homeostasis, resisting chronic inflammation and oxidative stress, resisting the consequences of disturbed homeostasis. This approach not only contributed to the understanding of general biological processes, but also provided a targeted search and development of BP to maintain the stability of homeostasis with MS.

Conclusions

The study results provided insight into new opportunities in the MS management.

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Funding

The study was carried out within the framework of the technological programme BR05236375 “Study of the features concerning genetic risk of diseases associated with metabolic syndrome in the Kazakh population, by order of the State Institution “Committee of Science under the Ministry of Education and Science of the Republic of Kazakhstan”.

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Authors and Affiliations

  1. Administrative Department, Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan, 010000, 80 Mangilik El Ave., Nur-Sultan, Republic of Kazakhstan

    Valery V. Benberin

  2. Sector оf Clinical Research, Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan, 010000, 80 Mangilik El Ave., Nur-Sultan, Republic of Kazakhstan

    Ainur S. Sibagatova

  3. Gerontology Centre, Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan, 010000, 80 Mangilik El Ave., Nur-Sultan, Republic of Kazakhstan

    Almagul A. Nagimtayeva, Kamshat M. Akhmetova & Tamara A. Voshchenkova

Authors
  1. Valery V. Benberin
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  2. Ainur S. Sibagatova
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  3. Almagul A. Nagimtayeva
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  4. Kamshat M. Akhmetova
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  5. Tamara A. Voshchenkova
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Corresponding author

Correspondence to Valery V. Benberin.

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This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1007/s40200-023-01242-0

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Benberin, V.V., Sibagatova, A.S., Nagimtayeva, A.A. et al. RETRACTED ARTICLE: Systematisation of biological protectors for managing the metabolic syndrome development. J Diabetes Metab Disord 20, 1449–1454 (2021). https://doi.org/10.1007/s40200-021-00883-3

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  • DOI: https://doi.org/10.1007/s40200-021-00883-3

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