Skip to main content

Advertisement

SpringerLink
Log in

Post-stroke Cognitive Impairment and Malnutrition in the Elderly (PCIME): study design and protocol

  • Study Protocol
  • Published:
Journal of Diabetes & Metabolic Disorders Aims and scope Submit manuscript

Abstract

Purpose

Stroke and dementia are burdensome non communicable diseases but preventable. A joint prevention of stroke and dementia requires a comprehensive approach by controlling common risk factors. Little is known about the role of malnutrition in post-stroke cognitive impairments. The main aim of this study is to evaluate the presence of cognitive impairment after stroke and its association with malnutrition.

Methods

Post-stroke Cognitive Impairment and Malnutrition in the Elderly (PCIME) is a prospective hospital-based cohort study, started on January 2nd, 2018 at Ziaeian Hospital, a referral center for elderly, Tehran, Iran, Middle East. We have used a battery of neuropsychiatric tests, including the Montreal Cognitive Assessment and Mini-Mental State Examination. We have assessed malnutrition using the Mini Nutritional Assessment and Geriatric Nutritional Risk Index.

Conclusion

PCIME will enable us to assess the role of malnutrition in development of post stroke dementia. This study will help clinicians and researchers develop preventive measures to reduce the burden of stroke and dementia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

Data availability

Data available.

References

  1. Avan A, Digaleh H, Napoli MD, Stranges S, Shojaeianbabaei G, Amiri A, Tabrizi R, Mokhber N, Spence D, Azarpazhooh MR. Socioeconomic status and stroke incidence, prevalence, mortality, and worldwide burden: an ecological analysis from the Global Burden of Disease Study 2017. BMC Med. 2019;17:191.

    Article  Google Scholar 

  2. Al-Qazzaz NK, Ali SH, Ahmad SA, Islam Sh. Cognitive assessments for the early diagnosis of dementia after stroke. Neuropsychiatr Dis Treat. 2014;10:1743–51.

    Article  Google Scholar 

  3. Azarpazhooh MR, Avan A, Cipriano LE, Munoz G, Sposato LA, Hachinski V. Concomitant vascular and neurodegenerative pathologies double the risk of dementia. Alzheimers Dement. 2018;14(2):148–56.

    Article  Google Scholar 

  4. Gomes F, Emery PW, Weekes CE. Risk of malnutrition is an independent predictor of mortality, length of hospital stay, and hospitalization costs in stroke patients. J Stroke Cerebrovasc Dis. 2016;25(4):799–806.

    Article  Google Scholar 

  5. Sabbouh T, Torbey MT. Malnutrition in stroke patients: risk factors, assessment, and management. Neurocrit Care. 2018;29(3):374–84.

    Article  Google Scholar 

  6. Yildiz D, BüyükkoyuncuPekel N, Kiliç AK, Tolgay EN, Tufan F. Malnutrition is associated with dementia severity and geriatric syndromes in patients with Alzheimer disease. Turk J Med Sci. 2015;45(5):1078–81.

    Article  CAS  Google Scholar 

  7. Gonzalez EW, Slaughter J, Di Maria-Ghalili R, Abeysekara P, Resnick H, Guenter H. Malnutrition a risk factor of mortality in hospitalized adults with dementia in the united states. Innov Aging. 2017;1(suppl_1):659.

    Article  Google Scholar 

  8. Otsuka M, Yamaguchi K, Ueki A. Similarities and differences between Alzheimer’s disease and vascular dementia from the viewpoint of nutrition. Ann N Y Acad Sci. 2002;977:155–61.

    Article  CAS  Google Scholar 

  9. Aho K, Harmsen P, Hatano S, Marquardsen J, Smirnov VE, Strasser T. Cerebrovascular disease in the community: results of a WHO collaborative study. Bull World Health Organ. 1980;58(1):113–30.

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Casadei K, Kiel J. Anthropometric measurement. Treasure Island: StatPearlsPublishing; 2020.

    Google Scholar 

  11. NIH_Stroke_Scale_Booklet.pdf. https://www.ninds.nih.gov/sites/default/files/NIH_Stroke_Scale_Booklet.pdf.

  12. Seyedian M, Falah M, Nourouzian M, Nejat S, Delavar A, Ghasemzadeh HA. Validity of the farsi version of mini-mental state examination. JIMC. 2008;25:408–14.

    Google Scholar 

  13. Emsaki G, Molavi H, Chitsaz A, MovahedAbtahi M, Asgari K. Psychometric Properties of the Montreal Cognitive Assessment (MoCA) in Parkinson’s Disease Patients in Isfahan. JIMS. 2011;158:1391–400.

    Google Scholar 

  14. Malakouti SK, Panaghi L, Foroughan M, Salehi M, Zandi T. Farsi version of the Neuropsychiatric Inventory: validity and reliability study among Iranian elderly with dementia. Intpsychogeriatrics. 2012;24(2):223–30.

    Google Scholar 

  15. Malakouti K, Fathollahi P, Mirabzadeh A, Salavati M, Kahani SH. Validation of geriatric depression scale (GDS-15) in Iran 2006. Res Med. 2006;30(4):361–9.

    Google Scholar 

  16. Amirkalali B, Sharifi F, Fakhrzadeh H, Mirarefin M, Ghaderpanahi M, Larijani B. Evaluation of the Mini Nutritional Assessment in the elderly, Tehran. Iran Public Health Nutr. 2010;13(9):1373–9.

    Article  Google Scholar 

  17. Durán Alert P, MilàVillarroel R, Formiga F, Virgili Casas N, Vilarasau FC. Assessing risk screening methods of malnutrition in geriatric patients: Mini Nutritional Assessment (MNA) versus Geriatric Nutritional Risk Index (GNRI). Nutr Hosp. 2012;27(2):590–8.

    PubMed  Google Scholar 

  18. Abd-El-Gawad WM, Abou-Hashem RM, El Maraghy MO, Amin GE. The validity of Geriatric Nutrition Risk Index: simple tool for prediction of nutritional-related complication of hospitalized elderly patients. Comparison with Mini Nutritional Assessment. Clin Nutr. 2014;33(6):1108–16.

    Article  Google Scholar 

  19. Azad A, Mohammadinezhad T, Taghizadeh G, Lajevardi L. Clinical assessment of activities of daily living in acute stroke: validation of the Persian version of Katz Index. Med J Islam RepubIran. 2017;31:30.

    Google Scholar 

  20. Hassani Mehraban A, Soltanmohamadi Y, Akbarfahimi M, Taghizadeh GH. Validity and reliability of the persian version of lawton instrumental activities of daily living scale in patients with dementia. Med J Islam Repub Iran. 2014;28:25.

    PubMed  PubMed Central  Google Scholar 

  21. Ghandehari K. Epidemiology of stroke in Iran. GMJ. 2016;5:3–9.

    Google Scholar 

  22. Azarpazhooh MR, Etemadi MM, Donnan GA, Mokhber N, Majdi MR, Ghayour-Mobarhan M, Ghandehary K, Farzadfard MT, Kiani R, Panahandeh M, Thrift AG. Excessive incidence of stroke in Iran: evidence from the Mashhad Stroke Incidence Study (MSIS), a population-based study of stroke in the Middle East. Stroke. 2010;41(1):3–10.

    Article  Google Scholar 

  23. Saadat S, Yousefifard M, Asady H, MoghadasJafari A, Fayaz M, Hosseini M. The most important causes of death in Iranian population; a retrospective cohort study. Emerg. 2015;3(1):16–21.

    Google Scholar 

Download references

Acknowledgements

We acknowledge the support of colleagues at Ziaeian hospital and Iranian Center of Neurological Research who provide insight and expertise greatly assisting the research.

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Author information

Authors and Affiliations

  1. Department of Geriatric Medicine, Ziaeian Hospital, Tehran University of Medical Sciences (TUMS), Abuzar St., P.O. Box 14155-6117, Tehran, Iran

    Zahra Vahabi, Shima Raeesi, Farnaz Etesam & Rezvan Hashemi

  2. Memory and Behavioral Neurology Division, Roozbeh Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Zahra Vahabi

  3. Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, ON, Canada

    M. Reza Azarpazhooh

  4. Department of Clinical Neurological Sciences, Western University, London, ON, Canada

    M. Reza Azarpazhooh

  5. Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada

    M. Reza Azarpazhooh

  6. Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA

    Shahram Oveisgharan

  7. Psychosomatic Medicine Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Farnaz Etesam

  8. Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Elahe Abedi-Taleb

Authors
  1. Zahra Vahabi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Reza Azarpazhooh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shima Raeesi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shahram Oveisgharan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Farnaz Etesam
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Elahe Abedi-Taleb
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Rezvan Hashemi
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

“ZV” and” SOG designed the study and developing the protocol. “RH” is the corresponding author, drafted the protocol paper and approving the final version.” RH” and” SR” contributed in study design and the development of outcome measures. “FE” and” EA” participated in manuscript preparation.” All authors read and approved the final manuscript.

Corresponding author

Correspondence to Rezvan Hashemi.

Ethics declarations

Ethics approval

This study was approved by the Ethic Committee of Iranian Center of Neurological Research with the ethics code of IR.TUMS.VCR.REC.1396.4098. Informed consent was obtained from all participants (the next of kin) prior to any interview or assessments.

Consent to participate

Not applicable for this manuscript.

Conflict of interest

Not applicable.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vahabi, Z., Azarpazhooh, M.R., Raeesi, S. et al. Post-stroke Cognitive Impairment and Malnutrition in the Elderly (PCIME): study design and protocol. J Diabetes Metab Disord 20, 2081–2084 (2021). https://doi.org/10.1007/s40200-021-00841-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40200-021-00841-z

Keywords

Search

Navigation