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The effect of probiotics on lipid profile & anthropometric indices in diabetic nephropathy; a systematic review and meta-analysis of clinical trials

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Abstract

Purpose

Recent trials have demonstrated the possible improvements in lipid profile & anthropometric indices after probiotics supplementation. We aimed to reanalyze the related literature to explore the efficacy of probiotics in Diabetic Nephropathy (DN) patients.

Methods

PubMed, Embase, Web of science, google scholar, Scopus, and Cochrane Library databases were systematically searched to find the related data on diabetic nephropathy population. All Randomized controlled trials (RCTs) that investigated the effect of probiotics on serum lipid markers (High-Density Lipoprotein [HDL], Triglyceride, Total Cholesterol, TC-to-HDL ratio, Low-Density Lipoprotein, Very Low-Density Lipoprotein) and anthropometric indices (Body Weight, Body Mass Index, waist-to-hip ratio) were included (PROSPERO No.CRD42020186189). Meta-analysis was performed using the random-effect model.

Results

Of 156 studies, seven were eligible for inclusion. Lipid biomarkers had a marginal reduction (except for HDL; WMD = 2.59 mg/dl; 95% CI = -0.28, 5.47; P = 0.077); whereas anthropometric indices increased in a non-significant manner.

Conclusion

There is limited evidence to support the efficacy of probiotics for the modulation of lipid profile and anthropometric indices in DN patients.

Graphical abstract

Probiotics did not beneficial effect on lipid profile & anthropometric markers in Diabetic Nephropathy; anyway, more trials should be conducted.

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Acknowledgements

This research was supported by Isfahan University of Medical Sciences, Isfahan, Iran.

PROSPERO Registration ID. CRD42020186189.

Authors’ contributions (CRediT author statement)

Amir Reza Moravejolahkami: Conceptualization, Investigation, Methodology, Software, Validation, Formal analysis, Writing - Original Draft.

Mohammad Ali Hojjati Kermani: Visualization, Project administration, Writing - Review & Editing.

Zakiyeh Balouch Zehi: Data Curation, Resources, Writing - Review & Editing.

Seyed Mohammad Sadegh Mirenayat: Writing - Review & Editing.

Marjan Mansourian: Supervision, Funding acquisition.

Author information

Authors and Affiliations

  1. Department of Clinical Nutrition, School of Nutrition & Food Science, Isfahan University of Medical Sciences, P.O. Box 81746-73461, Hezar-Jerib Ave, Isfahan, Iran

    Amir Reza Moravejolahkami

  2. Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mohammad Ali Hojjati Kermani

  3. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Zakiyeh Balouch Zehi

  4. Department of Community Nutrition, School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

    Seyed Mohammad Sadegh Mirenayat

  5. Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Science, P.O. Box 81746-73461, Hezar-Jerib Ave, Isfahan, Iran

    Marjan Mansourian

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  1. Amir Reza Moravejolahkami
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Correspondence to Amir Reza Moravejolahkami or Marjan Mansourian.

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Moravejolahkami, A., Hojjati Kermani, M., Balouch Zehi, Z. et al. The effect of probiotics on lipid profile & anthropometric indices in diabetic nephropathy; a systematic review and meta-analysis of clinical trials. J Diabetes Metab Disord 20, 893–904 (2021). https://doi.org/10.1007/s40200-021-00765-8

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  • DOI: https://doi.org/10.1007/s40200-021-00765-8

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