A low level of physical activity has a potential association with high levels of homocysteine, which implies an increased chance of older adults with type 2 diabetes mellitus developing cardiovascular disease (CVD). However, the effects of physical activity on homocysteine levels have been poorly explored in the literature. Therefore, this study compared homocysteine levels and cardiovascular risk among physically active and inactive older women with type 2 diabetes mellitus. Fifty-nine women with type 2 diabetes mellitus, between 60 and 91 years old, were evaluated. The level of physical activity was assessed using the International Physical Activity Questionnaire (IPAQ) long version to identify active and inactive older women. Blood samples were collected and anthropometric, body composition, and blood pressure measurements were performed to determine homocysteine levels and cardiovascular risk. The results demonstrated that active older women with type 2 diabetes mellitus have lower homocysteine values (F = 17.79, p < 0.001, ηp2 = 0.238), cardiovascular risk scores (F = 15.84, p = p < 0.001, ηp2 = 0.217), and waist circumferences (F = 2.95, p = 0.013, ηp2 = 0.049) when compared with inactive older women. It was concluded that there was a difference in the levels of homocysteine, cardiovascular risk, and waist circumference between active and inactive older women with type 2 diabetes. Active older women are less likely to have cardiovascular risk than inactive older women.
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International physical activity questionnaire
Informed consent form
High-performance liquid chromatography
Statistical Package for the Social Sciences
Body mass index
Physical activity of moderate to vigorous intensity
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The authors would like to thank the volunteers, collaborators of the research, and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES) for the financial support through scholarships—Finance Code 001.
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de Oliveira, J.J., e Silva, A.d.S., Ribeiro, A.G.S.V. et al. The effect of physical activity on total homocysteine concentrations and cardiovascular risk in older Brazilian adults with type 2 diabetes. J Diabetes Metab Disord (2021). https://doi.org/10.1007/s40200-021-00759-6
- Cardiac risk
- Cardiovascular diseases
- Physical inactivity