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RETRACTED ARTICLE: Luffa cylindrica: a promising herbal treatment in progesterone induced obesity in mice

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This article was retracted on 12 May 2023

This article has been updated

Abstract

Objective

The present study investigates the anti-obesity activity of Luffa cylindrica in progesterone induced obesity model.

Method

Swiss albino mice were grouped into 7 (n = 6). Obesity was induced by administration of progesterone (10 mg/kg s.c.) for 28 days. Normal group received ad libitum and water. Disease control, positive control and treatment groups received progesterone (10 mg/kg s.c.). Further positive control group received Orlistat (10 mg/kg p.o). Treatment groups received hydro-alcoholic and fractionation extract of Luffa cylindrica at doses 400, 200, 100 mg/kg b.w. Food and water intake were recorded daily, Body weight, BMI and blood glucose were checked weekly. On completion of the study, animals were sacrificed and blood serum being utilized to accesses in vitro to estimate the various biochemical parameters. Serotonin levels and antioxidant biomarkers were also estimated. Histopathology of liver and adipose tissue was studied.

Result

After the 28 days of treatment with plant extract and fraction, it was observed to improve the progestrogen-induced obesity by improving BMI, body weight, brain serotionin, locomotor activity, blood glucose level, anti-oxidant biomarkers, and lipid profile.

Conclusion

After assimilating the In vivo and in vitro studies Luffa cylindrical extract highlighted the antilipidemic, anti-hyperglycaemic, antioxidant potential in hormone-induced obesity.

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Abbreviations

BMI:

Body Mass Index

BW:

Body Weight

TG:

Triglycerides

TC:

Total Cholesterol

HDL:

High Density Lipoprotein

LDL:

Low Density-Lipoprotein

VLDL:

Very Low Density Lipoprotein

SGPT:

Serum Glutamic Pyruvic Transaminase

SGOT:

Serum Glutamic Oxaloacetic Transminase

LC extract:

Luffa cylindrical extract

Fraction of LC:

Luffa cylindrical extract fraction group

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Acknowledgements

The authors are thankful to Prof. Dr. S. S. Jalalpure Principal, KLE college of Pharmacy, Belagavi, Karnataka, India for providing necessary facilities, Prof. Dr. B. M. Patil and HOD for their suggestions. Further, we thank KAHER for cosidering for research funding the project.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research (KAHER), Belagavi, 590010, India

    Wilnoska Wilnellia D’silva, Prakash Rajshekhar Biradar & Ashwini Patil

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  1. Wilnoska Wilnellia D’silva
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  2. Prakash Rajshekhar Biradar
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  3. Ashwini Patil
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Contributions

All the Authors are designed equally involved in the study and the experiments and Reviewed the written drafted the manuscript. Contributed in conduct of the experiments, performed data analysis. The author(s) read and approved the final manuscript.

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Correspondence to Prakash Rajshekhar Biradar.

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This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1007/s40200-023-01233-1"

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D’silva, W.W., Biradar, P.R. & Patil, A. RETRACTED ARTICLE: Luffa cylindrica: a promising herbal treatment in progesterone induced obesity in mice. J Diabetes Metab Disord 20, 329–340 (2021). https://doi.org/10.1007/s40200-021-00749-8

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