Evaluation of MASP1, CMPF and U.A serum levels in pre-diabetic subjects in comparison to Normal individuals for early diagnosis of subjects with pre-diabetes, a case-control study

Abstract

Background

The present study designed to evaluate the Serum levels of CMPF, MASP1 and UA in pre-diabetic subjects was compared to normal subjects.

Methods

This research is a case-control study. We studied 44 pre-diabetics with 44 normal subjects and were evaluated serum concentration of CMPF, Masp1 and U.Ain both groups andfurthermore serum concentration FPG, BUN, Cr, Cho, TG, HDLc, LDLc, AST, ALT, ALP, HbA1c was examined and correlation between of CMPF, Masp1 and U.Aand other parameters was statistically analyzed.

Results

Serum levels of MASP1, CMPF, fasting plasma glucose (P < 0.001)and uric acid (P < 0.002) were significantly increased in pre-diabetic subjects. In this study, a significant difference was found between MASP1 and CMPF in pre-diabetic subjects compared to normal subjects (P=0.005, r=0.291). There was also a significant difference between serum levels of MASP1 with HbA1C (P=0.01, r=0.269).

Conclusion

Serum levels of CMPF, MASP1 and uric acid were increased in pre-diabetic subjects. These parameters can be used as a biomarker for the diagnosis of pre-diabetes.

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Acknowledgments

Authors wish to thank the patients that participated in the current study.

Funding

The study was financially supported by Hormozgan University of Medical Sciences (grant number: 960326).

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Correspondence to Soheila Moein.

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The authors declared no conflict of interest.

Ethical considerations

The study was approved by the Ethical Committee of Hormozgan University of Medical Sciences, Bandar Abbas, Iran (Code: IR.HUMS.REC.1397.048). All patients signed consent form before participation in the study.

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Authors declared no financial disclosure related to the material in the manuscript.

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Fardipour, S., Moein, S., Teshnizi, S.H. et al. Evaluation of MASP1, CMPF and U.A serum levels in pre-diabetic subjects in comparison to Normal individuals for early diagnosis of subjects with pre-diabetes, a case-control study. J Diabetes Metab Disord (2020). https://doi.org/10.1007/s40200-020-00697-9

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Keywords

  • Diabetes mellitus
  • Prediabetes
  • MASP1
  • CMPF
  • Uric acid
  • HbA1C
  • FBS