Abstract
Backgroud
Prevalence of skin lesions among diabetic patients is a major health concern. Therefore, this systematic review and meta-analysis study was conducted to determine the prevalence of skin lesions in diabetic patients.
Methods
To identify and select relevant articles, the SID, MagIran, IranMedex, IranDoc, Google Scholar, Cochrane, Embase, ScienceDirect, Scopus, PubMed, and Web of Science (WoS) databases were searched without a lower time limit and until April 2020. The random effects model was used to perform the analysis, and the heterogeneity of studies was assessed using the I2 index. Data were analyzed within the Comprehensive Meta-Analysis (Version 2) software.
Results
After evaluating the 22 final articles with a total sample size of 8406, the prevalence of skin lesions among diabetes patients were found as 70.3% (95% CI: 63–76.7%). Moreover, according to the meta-regression analysis, the effect of ‘sample size’ on th prevalence of skin lesions was significantly different in diabetes patients (p < 0.05).
Conclusion
The results of this study show that skin lesions are common in diabetes patients. Therefore, appropriate policies needs to be adopted to improve the situation and to monitor patients and outcomes at all levels.
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Data availability
Datasets are available through the corresponding author upon reasonable request.
Abbreviations
- DM:
-
Diabetes mellitus
- STROBE:
-
Strengthening the Reporting of Observational Studies in Epidemiology for cross- sectional Study
- PRISMA:
-
Preferred Reporting Items for Systematic Reviews and Meta-Analysis.
References
Mukherjee PK, Maiti K, Mukherjee K, Houghton PJ. Leads from Indian medicinal plants with hypoglycemic potentials. J Ethnopharmacol. 2006;106(1):1–28.
Wild SH, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030: response to Rathman and Giani. Diabetes care. 2004;27(10):2569.
Echouffo-Tcheugui JB, Dagogo-Jack S. Preventing diabetes mellitus in developing countries. Nat Rev Endocrinol. 2012;8(9):557–62.
Ferinkel R, Freinkel N. Cutaneous manifestations of endocrine diseases. u: Fitzpatrick TB i dr.[ur.]. Dermatology in general medicine, New York, itd: McGraw-Hill. 1993:2113–31.
Sibbald RG, Schachter RK. The skin and diabetes mellitus. Int J Dermatol. 1984;23(9):567–84.
Perez MI, Kohn SR. Cutaneous manifestations of diabetes mellitus. J Am Acad Dermatol. 1994;30(4):519–31.
Ragunatha S, Anitha B, Inamadar AC, Palit A, Devarmani SS. Cutaneous disorders in 500 diabetic patients attending diabetic clinic. Indian journal of dermatology. 2011;56(2):160–4.
Wohlrab J, Wohlrab D, Meiss F. Skin diseases in diabetes mellitus. Journal der Deutschen Dermatologischen Gesellschaft =. Journal of the German Society of Dermatology : JDDG. 2007;5(1):37–53.
Darjani A. Attar khataie A, Farrokhian K, Sobhani A. Kalantari S Prevalence of Skin Lesions in Diabetic Patients jour guilan uni med sci. 2002;11(43):60–6.
Majeed M, Iqbal F, Mehboob A. Frequency and association of cutaneous manifestations of diabetes mellitus with HbA1c. Proc Shaikh Zayed Postgrad Med Inst. 2004;18:85–9.
Khuraiya S, Lal N, Naseerudin VJ, Kachhawa D. A cross sectional study of cutaneous manifestations in 300 patients of diabetes mellitus. International Journal of Advances in Medicine. 2019;6(1):150.
Avula S, Masthansahib D, Latha MM. Cutaneous manifestations of diabetes mellitus: a cross-sectional study in a tertiary care hospital. Indian Journal of Mednodent and Allied Sciences. 2014;2(3):261–6.
Zimmo SK. Prevalence of skin manifestations in diabetes mellitus at King Abdulaziz University hospital. Saudi Journal of Internal Medicine. 2012;2(1):19–22.
Gupta SK, Singh P. Pattern of dermatological diseases in patients of diabetes mellitus. Journal of Pakistan Association of Dermatology. 2017;26(3):214–8.
Vathsala S, Murthy SC, Shashibhushan J. Cutaneous manifestations in diabetes mellitus: a study among 500 patients in a tertiary care center in South India. IP Indian Journal of Clinical and Experimental Dermatology. 2019;5(2):141–5.
Fatima K. Skin manifestations of diabetes mellitus. Journal of Rawalpindi Medical College. 2018:252–5.
Galdeano F, Zaccaria S, Parra V, Giannini ME, Salomón S. Cutaneous manifestations of diabetes mellitus: clinical meaning. Dermatología Argentina. 2013;16(2010):117–21.
Furqan S, Kamani L, Jabbar A. Skin manifestations in diabetes mellitus. Journal of Ayub Medical College Abbottabad. 2014;26(1):46–8.
Kiprono S, Minde E, Mavura D, Masenga J. Prevalence of cutaneous manifestations of diabetes mellitus: a hospital-based cross-sectional study in northern Tanzania. East Afr Med J. 2015;92(5):221–5.
Alwaash SS, Al-Shibly K. Dermatological manifestations of diabetes mellitus in Hilla City. Medical Journal of Babylon. 2017;14(3):495–500.
Sasmaz S, Buyukbese M, Cetinkaya A, Celik M, Arican O. The prevalence of skin disorders in type-2 diabetic patients. Int J Dermatol. 2005;3(1):1–4.
Hossaini MS, Ehsani AH, Hossainpanah F, Azizi F. Frequency of skin lesions among 1135 diabetic patients and their association with microvascular complications. Pejouhesh dar Pezeshki (Research in Medicine). 2006;30(3):193–9.
Ahmed K, Muhammad Z, Qayum I. Prevalence of cutaneous manifestations of diabetes mellitus. J Ayub Med Coll Abbottabad. 2009;21(2):76–9.
Verma A, Pandya P, Sharma D. Skin manifestations in patients with type-II diabetes mellitus. International Journal of Research and Review. 2019;6(9):59–65.
Devi AS, Lal BM. Skin manifestations in type 2 Dianetes mellitus. J Evid Based Med Healthc. 2016;3(61):3292–4.
Ahmed Wani M, Hassan I, Hayat Bhat M, Masood AQ. Cutaneous manifestations of diabetes mellitus: a hospital based study in Kashmir. India Egyptian Dermatology Online Journal. 2009;5(2):1–6.
Majeed M, Iqbal F, Mehboob A. Cutaneous manifestations in type-1 and type-2 diabetes mellitus (a study profile of 200 patients). Proc Shaikh Zayed Postgrad Med Inst. 2004;18:63–8.
Yaghmaei R, Rahimi E. A study on frequency of skin complications in diabetec patiences referring to tohid hospital in Sanandaj (Iran) in 2000. Scientific Journal of Kurdistan University of Medical Sciences. 2004;9(1):43–7.
Mahmood T. Ul Bari a, agha H. cutaneous manifestations of diabetes mellitus. Journal of Pakistan Association of Dermatology. 2016;15(3):227–32.
Vinnarasan M, Sindhuja R, Vinothiney K, Balaji G. Cutaneous manifestations of diabetes mellitus. Journal of Evolution of Medical and Dental Sciences-JEMDS. 2017;6(83):5815–9.
Kalus AA, Chien AJ, Olerud JE. Diabetes mellitus and other endocrine diseases. Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ Fitzpatrick’s Dermatology in General Medicine 7th edn New York: McGraw Hill. 2008:1461–84.
Mendes AL, Miot HA, Haddad VJ. Diabetes mellitus and the skin. An Bras Dermatol. 2017;92(1):8–20.
Duff M, Demidova O, Blackburn S, Shubrook J. Cutaneous manifestations of diabetes mellitus. Clinical diabetes : a publication of the American Diabetes Association. 2015;33(1):40–8.
de Macedo GM, Nunes S, Barreto T. Skin disorders in diabetes mellitus: an epidemiology and physiopathology review. Diabetology & metabolic syndrome. 2016;8(1):63–70.
Romano G, Moretti G, Di Benedetto A, Giofre C, Di Cesare E, Russo G, et al. Skin lesions in diabetes mellitus: prevalence and clinical correlations. Diabetes Res Clin Pract. 1998;39(2):101–6.
Vella J. Cutaneous markers of systemic disease in the lower extremity. Clin Podiatr Med Surg. 2016;33(3):423–40.
Rao GS, Pai GS. Cutaneous manifestations of diabetes mellitus. Indian journal of dermatology, venereology and leprology. 1997;63(4):232–4.
Mahajan S, Koranne R, Sharma S. Cutaneous manifestation of diabetes melitus. Indian Journal of Dermatology, Venereology, and Leprology. 2003;69(2):105.
Al-Mutairi N, Zaki A, Sharma AK, Al-Sheltawi M. Cutaneous manifestations of diabetes mellitus. Study from Farwaniya hospital, Kuwait. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2006;15(6):427–30.
Goyal A, Raina S, Kaushal SS, Mahajan V, Sharma NL. Pattern of cutaneous manifestations in diabetes mellitus. Indian journal of dermatology. 2010;55(1):39–41.
Chatterjee N, Chattopadhyay C, Sengupta N, Das C, Sarma N, Pal SK. An observational study of cutaneous manifestations in diabetes mellitus in a tertiary care Hospital of Eastern India. Indian journal of endocrinology and metabolism. 2014;18(2):217–20.
Nigam P, Pande S. Pattern of dermatoses in diabetics. Indian Journal of Dermatology, Venereology, and Leprology. 2003;69(2):83.
Acknowledgements
The authors would like to thank the faculty members of the Faculty of Nursing and Midwifery, Kermanshah University of Medical Sciences for their support with this research.
Authors’contributions
SHR and NS and SHR contributed to the design, MM and RJ statistical analysis, participated in most of the study steps. SHSH and AHF and AVR and SHR and MHF and HK prepared the manuscript. NS and MM and SHR assisted in designing the study, and contributed to the interpretation of the study. All authors have read and approved the content of the manuscript.
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Salari, N., Hosseinian-Far, A., Hosseinian-Far, M. et al. Evaluation of skin lesions in diabetic patients: a systematic review and meta-analysis. J Diabetes Metab Disord 19, 1909–1916 (2020). https://doi.org/10.1007/s40200-020-00629-7
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DOI: https://doi.org/10.1007/s40200-020-00629-7