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Evaluation of skin lesions in diabetic patients: a systematic review and meta-analysis

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Abstract

Backgroud

Prevalence of skin lesions among diabetic patients is a major health concern. Therefore, this systematic review and meta-analysis study was conducted to determine the prevalence of skin lesions in diabetic patients.

Methods

To identify and select relevant articles, the SID, MagIran, IranMedex, IranDoc, Google Scholar, Cochrane, Embase, ScienceDirect, Scopus, PubMed, and Web of Science (WoS) databases were searched without a lower time limit and until April 2020. The random effects model was used to perform the analysis, and the heterogeneity of studies was assessed using the I2 index. Data were analyzed within the Comprehensive Meta-Analysis (Version 2) software.

Results

After evaluating the 22 final articles with a total sample size of 8406, the prevalence of skin lesions among diabetes patients were found as 70.3% (95% CI: 63–76.7%). Moreover, according to the meta-regression analysis, the effect of ‘sample size’ on th prevalence of skin lesions was significantly different in diabetes patients (p < 0.05).

Conclusion

The results of this study show that skin lesions are common in diabetes patients. Therefore, appropriate policies needs to be adopted to improve the situation and to monitor patients and outcomes at all levels.

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Data availability

Datasets are available through the corresponding author upon reasonable request.

Abbreviations

DM:

Diabetes mellitus

STROBE:

Strengthening the Reporting of Observational Studies in Epidemiology for cross- sectional Study

PRISMA:

Preferred Reporting Items for Systematic Reviews and Meta-Analysis.

References

  1. Mukherjee PK, Maiti K, Mukherjee K, Houghton PJ. Leads from Indian medicinal plants with hypoglycemic potentials. J Ethnopharmacol. 2006;106(1):1–28.

    Article  CAS  PubMed  Google Scholar 

  2. Wild SH, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030: response to Rathman and Giani. Diabetes care. 2004;27(10):2569.

    Article  Google Scholar 

  3. Echouffo-Tcheugui JB, Dagogo-Jack S. Preventing diabetes mellitus in developing countries. Nat Rev Endocrinol. 2012;8(9):557–62.

    Article  PubMed  Google Scholar 

  4. Ferinkel R, Freinkel N. Cutaneous manifestations of endocrine diseases. u: Fitzpatrick TB i dr.[ur.]. Dermatology in general medicine, New York, itd: McGraw-Hill. 1993:2113–31.

  5. Sibbald RG, Schachter RK. The skin and diabetes mellitus. Int J Dermatol. 1984;23(9):567–84.

    Article  CAS  PubMed  Google Scholar 

  6. Perez MI, Kohn SR. Cutaneous manifestations of diabetes mellitus. J Am Acad Dermatol. 1994;30(4):519–31.

    Article  CAS  PubMed  Google Scholar 

  7. Ragunatha S, Anitha B, Inamadar AC, Palit A, Devarmani SS. Cutaneous disorders in 500 diabetic patients attending diabetic clinic. Indian journal of dermatology. 2011;56(2):160–4.

    PubMed  PubMed Central  Google Scholar 

  8. Wohlrab J, Wohlrab D, Meiss F. Skin diseases in diabetes mellitus. Journal der Deutschen Dermatologischen Gesellschaft =. Journal of the German Society of Dermatology : JDDG. 2007;5(1):37–53.

    PubMed  Google Scholar 

  9. Darjani A. Attar khataie A, Farrokhian K, Sobhani A. Kalantari S Prevalence of Skin Lesions in Diabetic Patients jour guilan uni med sci. 2002;11(43):60–6.

    Google Scholar 

  10. Majeed M, Iqbal F, Mehboob A. Frequency and association of cutaneous manifestations of diabetes mellitus with HbA1c. Proc Shaikh Zayed Postgrad Med Inst. 2004;18:85–9.

    Google Scholar 

  11. Khuraiya S, Lal N, Naseerudin VJ, Kachhawa D. A cross sectional study of cutaneous manifestations in 300 patients of diabetes mellitus. International Journal of Advances in Medicine. 2019;6(1):150.

    Article  Google Scholar 

  12. Avula S, Masthansahib D, Latha MM. Cutaneous manifestations of diabetes mellitus: a cross-sectional study in a tertiary care hospital. Indian Journal of Mednodent and Allied Sciences. 2014;2(3):261–6.

    Article  Google Scholar 

  13. Zimmo SK. Prevalence of skin manifestations in diabetes mellitus at King Abdulaziz University hospital. Saudi Journal of Internal Medicine. 2012;2(1):19–22.

    Article  Google Scholar 

  14. Gupta SK, Singh P. Pattern of dermatological diseases in patients of diabetes mellitus. Journal of Pakistan Association of Dermatology. 2017;26(3):214–8.

    Google Scholar 

  15. Vathsala S, Murthy SC, Shashibhushan J. Cutaneous manifestations in diabetes mellitus: a study among 500 patients in a tertiary care center in South India. IP Indian Journal of Clinical and Experimental Dermatology. 2019;5(2):141–5.

    Article  Google Scholar 

  16. Fatima K. Skin manifestations of diabetes mellitus. Journal of Rawalpindi Medical College. 2018:252–5.

  17. Galdeano F, Zaccaria S, Parra V, Giannini ME, Salomón S. Cutaneous manifestations of diabetes mellitus: clinical meaning. Dermatología Argentina. 2013;16(2010):117–21.

    Google Scholar 

  18. Furqan S, Kamani L, Jabbar A. Skin manifestations in diabetes mellitus. Journal of Ayub Medical College Abbottabad. 2014;26(1):46–8.

    Google Scholar 

  19. Kiprono S, Minde E, Mavura D, Masenga J. Prevalence of cutaneous manifestations of diabetes mellitus: a hospital-based cross-sectional study in northern Tanzania. East Afr Med J. 2015;92(5):221–5.

    Google Scholar 

  20. Alwaash SS, Al-Shibly K. Dermatological manifestations of diabetes mellitus in Hilla City. Medical Journal of Babylon. 2017;14(3):495–500.

    Google Scholar 

  21. Sasmaz S, Buyukbese M, Cetinkaya A, Celik M, Arican O. The prevalence of skin disorders in type-2 diabetic patients. Int J Dermatol. 2005;3(1):1–4.

    Google Scholar 

  22. Hossaini MS, Ehsani AH, Hossainpanah F, Azizi F. Frequency of skin lesions among 1135 diabetic patients and their association with microvascular complications. Pejouhesh dar Pezeshki (Research in Medicine). 2006;30(3):193–9.

    Google Scholar 

  23. Ahmed K, Muhammad Z, Qayum I. Prevalence of cutaneous manifestations of diabetes mellitus. J Ayub Med Coll Abbottabad. 2009;21(2):76–9.

    PubMed  Google Scholar 

  24. Verma A, Pandya P, Sharma D. Skin manifestations in patients with type-II diabetes mellitus. International Journal of Research and Review. 2019;6(9):59–65.

    Google Scholar 

  25. Devi AS, Lal BM. Skin manifestations in type 2 Dianetes mellitus. J Evid Based Med Healthc. 2016;3(61):3292–4.

    Article  Google Scholar 

  26. Ahmed Wani M, Hassan I, Hayat Bhat M, Masood AQ. Cutaneous manifestations of diabetes mellitus: a hospital based study in Kashmir. India Egyptian Dermatology Online Journal. 2009;5(2):1–6.

    Google Scholar 

  27. Majeed M, Iqbal F, Mehboob A. Cutaneous manifestations in type-1 and type-2 diabetes mellitus (a study profile of 200 patients). Proc Shaikh Zayed Postgrad Med Inst. 2004;18:63–8.

    Google Scholar 

  28. Yaghmaei R, Rahimi E. A study on frequency of skin complications in diabetec patiences referring to tohid hospital in Sanandaj (Iran) in 2000. Scientific Journal of Kurdistan University of Medical Sciences. 2004;9(1):43–7.

    Google Scholar 

  29. Mahmood T. Ul Bari a, agha H. cutaneous manifestations of diabetes mellitus. Journal of Pakistan Association of Dermatology. 2016;15(3):227–32.

    Google Scholar 

  30. Vinnarasan M, Sindhuja R, Vinothiney K, Balaji G. Cutaneous manifestations of diabetes mellitus. Journal of Evolution of Medical and Dental Sciences-JEMDS. 2017;6(83):5815–9.

    Article  Google Scholar 

  31. Kalus AA, Chien AJ, Olerud JE. Diabetes mellitus and other endocrine diseases. Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ Fitzpatrick’s Dermatology in General Medicine 7th edn New York: McGraw Hill. 2008:1461–84.

  32. Mendes AL, Miot HA, Haddad VJ. Diabetes mellitus and the skin. An Bras Dermatol. 2017;92(1):8–20.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Duff M, Demidova O, Blackburn S, Shubrook J. Cutaneous manifestations of diabetes mellitus. Clinical diabetes : a publication of the American Diabetes Association. 2015;33(1):40–8.

    Article  Google Scholar 

  34. de Macedo GM, Nunes S, Barreto T. Skin disorders in diabetes mellitus: an epidemiology and physiopathology review. Diabetology & metabolic syndrome. 2016;8(1):63–70.

    Article  Google Scholar 

  35. Romano G, Moretti G, Di Benedetto A, Giofre C, Di Cesare E, Russo G, et al. Skin lesions in diabetes mellitus: prevalence and clinical correlations. Diabetes Res Clin Pract. 1998;39(2):101–6.

    Article  CAS  PubMed  Google Scholar 

  36. Vella J. Cutaneous markers of systemic disease in the lower extremity. Clin Podiatr Med Surg. 2016;33(3):423–40.

    Article  PubMed  Google Scholar 

  37. Rao GS, Pai GS. Cutaneous manifestations of diabetes mellitus. Indian journal of dermatology, venereology and leprology. 1997;63(4):232–4.

    CAS  PubMed  Google Scholar 

  38. Mahajan S, Koranne R, Sharma S. Cutaneous manifestation of diabetes melitus. Indian Journal of Dermatology, Venereology, and Leprology. 2003;69(2):105.

    CAS  Google Scholar 

  39. Al-Mutairi N, Zaki A, Sharma AK, Al-Sheltawi M. Cutaneous manifestations of diabetes mellitus. Study from Farwaniya hospital, Kuwait. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2006;15(6):427–30.

    Article  Google Scholar 

  40. Goyal A, Raina S, Kaushal SS, Mahajan V, Sharma NL. Pattern of cutaneous manifestations in diabetes mellitus. Indian journal of dermatology. 2010;55(1):39–41.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Chatterjee N, Chattopadhyay C, Sengupta N, Das C, Sarma N, Pal SK. An observational study of cutaneous manifestations in diabetes mellitus in a tertiary care Hospital of Eastern India. Indian journal of endocrinology and metabolism. 2014;18(2):217–20.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Nigam P, Pande S. Pattern of dermatoses in diabetics. Indian Journal of Dermatology, Venereology, and Leprology. 2003;69(2):83.

    CAS  Google Scholar 

Download references

Acknowledgements

The authors would like to thank the faculty members of the Faculty of Nursing and Midwifery, Kermanshah University of Medical Sciences for their support with this research.

Authors’contributions

SHR and NS and SHR contributed to the design, MM and RJ statistical analysis, participated in most of the study steps. SHSH and AHF and AVR and SHR and MHF and HK prepared the manuscript. NS and MM and SHR assisted in designing the study, and contributed to the interpretation of the study. All authors have read and approved the content of the manuscript.

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Correspondence to Shna Rasoulpoor or Masoud Mohammadi.

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Salari, N., Hosseinian-Far, A., Hosseinian-Far, M. et al. Evaluation of skin lesions in diabetic patients: a systematic review and meta-analysis. J Diabetes Metab Disord 19, 1909–1916 (2020). https://doi.org/10.1007/s40200-020-00629-7

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