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Effect of Curculigo pilosa supplemented diet on blood sugar, lipid metabolism, hepatic oxidative stress and carbohydrate metabolism enzymes in streptozotocin-induced diabetic rats

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Abstract

Background

Diabetes mellitus (DM) has continued to raise concern globally and Curculigo pilosa (CP) is used for its treatment and management in folkloric medicine. In this study, the in vitro antioxidant abilities of CP and the effects of CP-supplemented diets on blood sugar, lipid metabolism, oxidative stress and key carbohydrate metabolizing enzymes in streptozotocin (STZ)-induced diabetic rats were investigated.

Methods

Polyphenol contents (total phenolic and total flavonoid) and antioxidant ability of different extracts of CP were determined in vitro. Diabetes mellitus were stimulated in healthy rats by single intraperitoneal administration of 50 mg/kg streptozotocin and it was confirmed by elevated blood glucose level after 3 days. Thirty six rats were distributed into six groups of six rats each and diabetic rats were fed with 5 and 10% CP-supplemented diet for 21 days. Thereafter, the effects of the dietary regimen were evaluated on blood glucose, body weight, hepatic carbohydrate metabolizing enzymes, lipid profile, oxidative stress markers, serum markers of hepatic and renal damages and histopathology studies.

Results

Different extracts of CP contained polyphenol contents and exhibited antioxidant properties in different models used. Diabetic rats showed elevated level of blood glucose and body weight loss. Treatment of diabetic rats with CP-supplemented diet significantly (p < 0.05) lowered the blood glucose and improved body weight loss. Also, the treatment with the CP-supplemented diet significantly (p < 0.05) enhanced the activities of hepatic glycolytic (hexokinase and glucose-6-dehydrogenase) and lowered the gluconeogenic (fructose 1, 6 biphosphatase and glucose-6-phosphatase) enzymes in diabetic rats. The lipid profile, oxidative stress markers and serum markers of hepatic and renal damages were significantly (p < 0.05) restored to near normalcy in the diabetic rats. Histopathological slides also showed improvements in pancreas and hepatic tissues of diabetic rats treated with CP-supplemented diet.

Conclusion

Data obtained in this study suggested that CP-supplemented diet could be used as dietary regimen in the management of DM.

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Authors and Affiliations

  1. Department of Chemical Sciences, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo state, Nigeria

    Kayode Olayele Karigidi, Emmanuel Sina Akintimehin & Foluso Olutope Adetuyi

  2. Nutritional and Industrial Biochemistry Research Laboratories, Department of Biochemistry, University of Ibadan, Ibadan, Nigeria

    Kayode Olayele Karigidi & Charles Ojo Olaiya

  3. Department of Biochemistry, Adekunle Ajasin University, Akungba Akoko, Nigeria

    Damilola Alex Omoboyowa

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Karigidi, K.O., Akintimehin, E.S., Omoboyowa, D.A. et al. Effect of Curculigo pilosa supplemented diet on blood sugar, lipid metabolism, hepatic oxidative stress and carbohydrate metabolism enzymes in streptozotocin-induced diabetic rats. J Diabetes Metab Disord 19, 1173–1184 (2020). https://doi.org/10.1007/s40200-020-00618-w

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