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The effect of green coffee extract supplementation on cardio metabolic risk factors: a systematic review and meta-analysis of randomized controlled trials

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Abstract

Purpose

Considering the present controversies on the association between green coffee supplementation and cardio metabolic risk factors, this systematic review and meta-analysis was conducted to evaluate the effect of green coffee supplementation on cardio metabolic risk factors.

Method

A systematic literature search was performed throughout the PubMed, Embase, Scopus, and Web of Science databases up to October 2019. As a result, all randomized controlled trials over the effect of green coffee supplementation on fasting blood sugar (FBS), insulin, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), C - reactive protein (CRP), and homeostatic model assessment for insulin resistance (HOMA-IR) in adults were examined. Data were extracted from the relevant studies and analyzed using the random-effect or pooled model and standardized mean difference (SMD) with 95% confidence interval (CI).

Results

After excluding the irrelevant articles, 27 studies were included in the final analysis. Pooled results revealed that green coffee supplementation significantly reduced FBS (WMD = −2.28, 95% CI: −4.49 to −0.07, P = 0.043), insulin (WMD = −0.53, 95% CI: −0.93 to −0.14, P = 0.008), and triglyceride (WMD = −9.28, 95% CI: −14.93 to - 3.63, P = 0.001). Furthermore, green coffee supplementation increased the HDL levels (WMD = 1.33, 95% CI: 0.08 to 2.58, P = 0.037). However, the changes in HOMA-IR, LDL, and CRP levels were not significant (P > 0.05).

Conclusion

This meta-analysis indicated that green coffee supplementation significantly decreased FBS, insulin, and triglyceride, but improved HDL. No statistically significant improvement was found in HOMA-IR, LDL, and CRP indices following the green coffee supplementation.

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References

  1. Zhang D, Tang X, Shen P, Si Y, Liu X, Xu Z, et al. Multimorbidity of cardiometabolic diseases: prevalence and risk for mortality from one million Chinese adults in a longitudinal cohort study. BMJ Open. 2019;9(3):e024476.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Takami H, Nakamoto M, Uemura H, Katsuura S, Yamaguchi M, Hiyoshi M, et al. Inverse correlation between coffee consumption and prevalence of metabolic syndrome: baseline survey of the Japan multi-institutional collaborative cohort (J-MICC) study in Tokushima. Japan J Epidemiol. 2013;23(1):12–20.

    Article  PubMed  Google Scholar 

  3. Dhingra R, Sullivan L, Jacques PF, Wang TJ, Fox CS, Meigs JB, et al. Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. Circulation. 2007;116(5):480–8.

    Article  PubMed  Google Scholar 

  4. Heidemann C, Scheidt-Nave C, Richter A, Mensink GB. Dietary patterns are associated with cardiometabolic risk factors in a representative study population of German adults. Br J Nutr. 2011;106(8):1253–62.

    Article  CAS  PubMed  Google Scholar 

  5. Goodpaster BH, DeLany JP, Otto AD, Kuller L, Vockley J, South-Paul JE, et al. Effects of diet and physical activity interventions on weight loss and cardiometabolic risk factors in severely obese adults: a randomized trial. JAMA. 2010;304(16):1795–802.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. J Nutr. 2000;130(8):2073S–85S.

    Article  CAS  PubMed  Google Scholar 

  7. Menezes R, Rodriguez-Mateos A, Kaltsatou A, González-Sarrías A, Greyling A, Giannaki C, et al. Impact of flavonols on cardiometabolic biomarkers: a meta-analysis of randomized controlled human trials to explore the role of inter-individual variability. Nutrients. 2017;9(2):117.

    Article  PubMed Central  CAS  Google Scholar 

  8. Gardiner P, Phillips RS, Shaughnessy AF. Herbal and dietary supplement-drug interactions in patients with chronic illnesses. Am Fam Physician. 2008;77(1):73–8.

    PubMed  Google Scholar 

  9. Cornelis MC. Toward systems epidemiology of coffee and health. Curr Opin Lipidol. 2015;26(1):20–9.

    Article  CAS  PubMed  Google Scholar 

  10. Li Q, Liu Y, Sun X, Yin Z, Li H, Cheng C, et al. Caffeinated and decaffeinated coffee consumption and risk of all-cause mortality: a dose–response meta-analysis of cohort studies. J Acad Nutr Diet. 2019;32(3):279–87.

    Article  CAS  Google Scholar 

  11. Gaafar A, El-Ghamery H, Mahmuod S. Effect of green and degree of roasted Arabic coffee on hyperlipidemia and antioxidant status in diabetic rats. Adv J Food Sci Technol. 2013;5(5):619–26.

    Article  Google Scholar 

  12. Farrell TL, Dew TP, Poquet L, Hanson P, Williamson G. Absorption and metabolism of chlorogenic acids in cultured gastric epithelial monolayers. Drug Metab Dispos. 2011;39(12):2338–46.

    Article  CAS  PubMed  Google Scholar 

  13. Tajik N, Tajik M, Mack I, Enck P. The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature. Eur J Nutr. 2017;56(7):2215–44.

    Article  CAS  PubMed  Google Scholar 

  14. Loader TB, Taylor CG, Zahradka P, Jones PJ. Chlorogenic acid from coffee beans: evaluating the evidence for a blood pressure-regulating health claim. Nutr Rev. 2017;75(2):114–33.

    PubMed  Google Scholar 

  15. Yamagata K, Izawa Y, Onodera D, Tagami M. Chlorogenic acid regulates apoptosis and stem cell marker-related gene expression in A549 human lung cancer cells. Mol Cell Biochem. 2018;441(1–2):9–19.

    Article  CAS  PubMed  Google Scholar 

  16. Santana-Galvez J, Cisneros-Zevallos L, Jacobo-Velazquez DA. Chlorogenic Acid: Recent Advances on Its Dual Role as a Food Additive and a Nutraceutical against Metabolic Syndrome. Molecules. 2017;22(3).

  17. Meng S, Cao J, Feng Q, Peng J, Hu Y. Roles of chlorogenic acid on regulating glucose and lipids metabolism: a review. Evid.-Based Complementary Altern. Med. 2013;2013.

  18. Ong KW, Hsu A, Tan BKH. Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation. Biochem Pharmacol. 2013;85(9):1341–51.

    Article  CAS  PubMed  Google Scholar 

  19. Cho AS, Jeon SM, Kim MJ, Yeo J, Seo KI, Choi MS, et al. Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice. Food Chem Toxicol. 2010;48(3):937–43.

    Article  CAS  PubMed  Google Scholar 

  20. Ma Y, Gao M, Liu D. Chlorogenic acid improves high fat diet-induced hepatic steatosis and insulin resistance in mice. Pharm Res. 2015;32(4):1200–9.

    Article  CAS  PubMed  Google Scholar 

  21. Han B, Nazary-Vannani A, Talaei S, Clark CCT, Rahmani J, Rasekhmagham R, et al. The effect of green coffee extract supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2019;33(11):2918–26.

    Article  CAS  PubMed  Google Scholar 

  22. Haidari F, Samadi M, Mohammadshahi M, Jalali MT, Engali KA. Energy restriction combined with green coffee bean extract affects serum adipocytokines and the body composition in obese women. Asia Pac J Clin Nutr. 2017;26(6):1048–54.

    CAS  PubMed  Google Scholar 

  23. Roshan H, Nikpayam O, Sedaghat M, Sohrab G. Effects of green coffee extract supplementation on anthropometric indices, glycaemic control, blood pressure, lipid profile, insulin resistance and appetite in patients with the metabolic syndrome: a randomised clinical trial. Br J Nutr. 2018;119(3):250–8.

    Article  CAS  PubMed  Google Scholar 

  24. Ochiai R, Jokura H, Suzuki A, Tokimitsu I, Ohishi M, Komai N, et al. Green coffee bean extract improves human vasoreactivity. Hypertens Res. 2004;27(10):731–7.

    Article  CAS  PubMed  Google Scholar 

  25. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264–9.

    Article  Google Scholar 

  26. Higgins JP, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Banitalebi E, Rahimi A, Faramarzi M, Ghahfarrokhi MM. The effects of elastic resistance band training and green coffee bean extract supplement on novel combined indices of cardiometabolic risk in obese women. Res Pharm Sci. 2019;14(5):414–23.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Fasihi M, Yousefi M. Safaiyan A. Rostami M, Barzegar A. Effects of green coffee extract supplementation on level of chemerin, malondialdehyde, nutritional and metabolic status in patients with metabolic syndrome. Nutrition & Food Science: Mele MM; 2019.

    Google Scholar 

  29. Mansour A, Mohajeri-Tehrani MR, Samadi M, Qorbani M, Merat S, Adibi H, et al. Effects of supplementation with Main coffee components on hepatic, metabolic, and inflammatory indices in patients with non-alcoholic fatty liver disease and type 2 diabetes: a randomized, double-blind, placebo-controlled. Clinical Trial J Diabetes Endocrinol. 2019;2.

  30. Sarriá B, Martínez-López S, Mateos R, Bravo-Clemente L. Long-term consumption of a green/roasted coffee blend positively affects glucose metabolism and insulin resistance in humans. Food Res Int. 2016;89:1023–8.

    Article  CAS  Google Scholar 

  31. Suzuki A, Nomura T, Jokura H, Kitamura N, Saiki A, Fujii A. Chlorogenic acid-enriched green coffee bean extract affects arterial stiffness assessed by the cardio-ankle vascular index in healthy men: a pilot study. Int J Food Sci Nutr. 2019:1–8.

  32. Alhamhany NN, Alassady EH. Does green coffee has a positive effect on body mass index and lipid profile in a sample of obese people. J Chem Pharm Res. 2018;10(3):627–30.

    CAS  Google Scholar 

  33. Aljamal A. Effect of Xenical and green coffee on BMI and lipid profiles among Jordanian people. J Chem Pharm Res. 2018;10(10):80–3.

    CAS  Google Scholar 

  34. Hosseinabadi S. Effect of green coffee extract supplementation on metabolic status, serum leptin level and anthropometric measurements in patients with non-alcoholic fatty liver disease (NAFLD): Tabriz University of Medical Sciences, Faculty of Nutrition and Food Sciences; 2018.

    Google Scholar 

  35. Katada S, Watanabe T, Mizuno T, Kobayashi S, Takeshita M, Osaki N, et al. Effects of Chlorogenic acid-enriched and Hydroxyhydroquinone-reduced coffee on postprandial fat oxidation and Antioxidative capacity in healthy men: a randomized, double-blind, placebo-controlled. Crossover Trial Nutrients. 2018;10(4):525.

    Google Scholar 

  36. Martinez-Lopez S, Sarria B, Mateos R, Bravo-Clemente L. Moderate consumption of a soluble green/roasted coffee rich in caffeoylquinic acids reduces cardiovascular risk markers: results from a randomized, cross-over, controlled trial in healthy and hypercholesterolemic subjects. Eur J Nutr. 2019;58(2):865–78.

    Article  CAS  PubMed  Google Scholar 

  37. Salamat S, Mohammadshahi FHM, Haghighizadeh M, Heli B, Mohammadshahi M. The effect of green coffee bean extract supplementation on anthropometric indices, lipid profile and high-sensitivity C-reactive protein in adult men with dyslipidemia. J Biochem Tech. 2018;2:75–81.

    Google Scholar 

  38. Zuniga LY, Aceves-de la Mora MCA, Gonzalez-Ortiz M, Ramos-Nunez JL, Martinez-Abundis E. effect of Chlorogenic acid administration on glycemic control, insulin secretion, and insulin sensitivity in patients with impaired glucose tolerance. J Med Food 2018;21(5):469–473.

  39. Fukagawa S, Haramizu S, Sasaoka S, Yasuda Y, Tsujimura H, Murase T. Coffee polyphenols extracted from green coffee beans improve skin properties and microcirculatory function. Biosci Biotechnol Biochem. 2017;81(9):1814–22.

    Article  CAS  PubMed  Google Scholar 

  40. Shahmohammadi HA, Hosseini SA, Hajiani E, Malehi AS, Alipour M. Effects of green coffee bean extract supplementation on patients with non-alcoholic fatty liver disease: a randomized clinical trial. Hepat Mon. 2017;17(4).

  41. Naderi L, Sharifi G. Comparison of the effect of 8 weeks concurrent training and green coffee supplementation on serum adipsin and insulin resistance in obese women. Armaghane danesh. 2017;22(5):623–36.

    Google Scholar 

  42. Nikpayam O, Roshan H, Sohrab G, Sedaghat M. Effects of Green Coffee Extract Supplementation on Oxidative Stress, Systemic and Vascular Inflammation in Patients with Metabolic Syndrome: A Randomized Clinical Trial. Iran Red Crescent Med J. 2018;20(6).

  43. Agudelo-Ochoa GM, Pulgarin-Zapata IC, Velasquez-Rodriguez CM, Duque-Ramirez M, Naranjo-Cano M, Quintero-Ortiz MM, et al. Coffee consumption increases the antioxidant capacity of plasma and has no effect on the lipid profile or vascular function in healthy adults in a randomized controlled trial. J Nutr. 2016;146(3):524–31.

    Article  CAS  PubMed  Google Scholar 

  44. Kim T-S, Yang W-S, Park S-I, Lee S-P, Kang M-H, Lee J-H, et al. Effect of green coffee bean extract supplementation on body fat reduction in mildly obese women. J Korean Soc Food Cult. 2012;27(4):407–13.

    Article  Google Scholar 

  45. van Rooij J, Van der Stegen G, Schoemaker RC, Kroon C, Burggraaf J, Hollaar L, et al. A placebo-controlled parallel study of the effect of two types of coffee oil on serum lipids and transaminases: identification of chemical substances involved in the cholesterol-raising effect of coffee. Am J Clin Nutr. 1995;61(6):1277–83.

    Article  PubMed  Google Scholar 

  46. Kozuma K, Tsuchiya S, Kohori J, Hase T, Tokimitsu I. Antihypertensive effect of green coffee bean extract on mildly hypertensive subjects. Hypertens Res. 2005;28(9):711–8.

    Article  CAS  PubMed  Google Scholar 

  47. Blum J, Lemaire B, Lafay S. Effect of a green decaffeinated coffee extract on glycaemia. NutraFoods Res. 2007;6:13–7.

    CAS  Google Scholar 

  48. Watanabe T, Arai Y, Mitsui Y, Kusaura T, Okawa W, Kajihara Y, et al. The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension. Clin Exp Hypertens. 2006;28(5):439–49.

    Article  CAS  PubMed  Google Scholar 

  49. Sarria B, Martinez-Lopez S, Sierra-Cinos JL, Garcia-Diz L, Mateos R, Bravo-Clemente L. Regularly consuming a green/roasted coffee blend reduces the risk of metabolic syndrome. Eur J Nutr. 2018;57(1):269–78.

    Article  CAS  PubMed  Google Scholar 

  50. Park JY, Kim JY, Lee SP, Lee JH. The effect of green coffee bean extract supplementation on body fat reduction in overweight/obese women. Korean J Nutr. 2010;43(4):374–81.

    Article  CAS  Google Scholar 

  51. Jin S, Chang C, Zhang L, Liu Y, Huang X, Chen Z. Chlorogenic acid improves late diabetes through adiponectin receptor signaling pathways in db/db mice. PLoS One. 2015;10(4):e0120842.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  52. Nikpayam O, Najafi M, Ghaffari S, Jafarabadi MA, Sohrab G, Roshanravan N. Effects of green coffee extract on fasting blood glucose, insulin concentration and homeostatic model assessment of insulin resistance (HOMA-IR): a systematic review and meta-analysis of interventional studies. Diabetol Metab Syndr. 2019;11:91.

    Article  PubMed  PubMed Central  Google Scholar 

  53. van Dijk AE, Olthof MR, Meeuse JC, Seebus E, Heine RJ, van Dam RM. Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance. Diabetes Care. 2009;32(6):1023–5.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  54. Song SJ, Choi S, Park T. Decaffeinated green coffee bean extract attenuates diet-induced obesity and insulin resistance in mice. Evid Based Complement Alternat Med. 2014;718379.

  55. Johnston KL, Clifford MN, Morgan LM. Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. Am J Clin Nutr. 2003;78(4):728–33.

    Article  CAS  PubMed  Google Scholar 

  56. Tunnicliffe JM, Eller LK, Reimer RA, Hittel DS, Shearer J. Chlorogenic acid differentially affects postprandial glucose and glucose-dependent insulinotropic polypeptide response in rats. Appl Physiol Nutr Metab. 2011;36(5):650–9.

    Article  PubMed  Google Scholar 

  57. Ong KW, Hsu A, Tan BKH. Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes. PloS one. 2012;7(3):e32718-e.

  58. Narita Y, Inouye K. Kinetic analysis and mechanism on the inhibition of chlorogenic acid and its components against porcine pancreas alpha-amylase isozymes I and II. J Agric Food Chem. 2009;57(19):9218–25.

    Article  CAS  PubMed  Google Scholar 

  59. Oboh G, Agunloye OM, Adefegha SA, Akinyemi AJ, Ademiluyi AO. Caffeic and chlorogenic acids inhibit key enzymes linked to type 2 diabetes (in vitro): a comparative study. J Basic Clin Physiol Pharmacol. 2015;26(2):165–70.

    Article  CAS  PubMed  Google Scholar 

  60. Li SY, Chang CQ, Ma FY, Yu CL. Modulating effects of chlorogenic acid on lipids and glucose metabolism and expression of hepatic peroxisome proliferator-activated receptor-alpha in golden hamsters fed on high fat diet. Biomed Environ Sci. 2009;22(2):122–9.

    Article  CAS  PubMed  Google Scholar 

  61. Henry-Vitrac C, Ibarra A, Roller M, Merillon JM, Vitrac X. Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract. J Agric Food Chem. 2010;58(7):4141–4.

    Article  CAS  PubMed  Google Scholar 

  62. Welsch CA, Lachance PA, Wasserman BP. Dietary phenolic compounds: inhibition of Na+−dependent D-glucose uptake in rat intestinal brush border membrane vesicles. J Nutr. 1989;119(11):1698–704.

    Article  CAS  PubMed  Google Scholar 

  63. Kempf K, Herder C, Erlund I, Kolb H, Martin S, Carstensen M, et al. Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial. Am J Clin Nutr. 2010;91(4):950–7.

    Article  CAS  PubMed  Google Scholar 

  64. Kondo Y, Goto A, Noma H, Iso H, Hayashi K, Noda M. Effects of Coffee and Tea Consumption on Glucose Metabolism: A Systematic Review and Network Meta-Analysis. Nutrients. 2018 ;11(1).

  65. Rodriguez de Sotillo DV, Hadley M. Chlorogenic acid modifies plasma and liver concentrations of: cholesterol, triacylglycerol, and minerals in (fa/fa) Zucker rats. J Nutr Biochem. 2002;13(12):717–26.

    Article  CAS  PubMed  Google Scholar 

  66. Ding F, Ma B, Nazary-Vannani A, Kord-Varkaneh H, Fatahi S, Papageorgiou M, et al. The effects of green coffee bean extract supplementation on lipid profile in humans: a systematic review and meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis. 2020;30(1):1–10.

    Article  CAS  PubMed  Google Scholar 

  67. Choi BK, Park SB, Lee DR, Lee HJ, Jin YY, Yang SH, et al. Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice. Asian Pac J Trop Med. 2016;9(7):635–43.

    Article  CAS  PubMed  Google Scholar 

  68. Yukawa GS, Mune M, Otani H, Tone Y, Liang XM, Iwahashi H, et al. Effects of coffee consumption on oxidative susceptibility of low-density lipoproteins and serum lipid levels in humans. Biochemistry (Mosc). 2004;69(1):70–4.

    Article  CAS  Google Scholar 

  69. Oboh G, Agunloye OM, Akinyemi AJ, Ademiluyi AO, Adefegha SA. Comparative study on the inhibitory effect of caffeic and chlorogenic acids on key enzymes linked to Alzheimer’s disease and some pro-oxidant induced oxidative stress in rats’ brain-in vitro. Neurochem Res. 2013;38(2):413–9.

    Article  CAS  PubMed  Google Scholar 

  70. Aro A, Tuomilehto J, Kostiainen E, Uusitalo U, Pietinen P. Boiled coffee increases serum low density lipoprotein concentration. Metabolism. 1987;36(11):1027–30.

    Article  CAS  PubMed  Google Scholar 

  71. Cai L, Ma D, Zhang Y, Liu Z, Wang P. The effect of coffee consumption on serum lipids: a meta-analysis of randomized controlled trials. Eur J Clin Nutr. 2012;66(8):872–7.

    Article  CAS  PubMed  Google Scholar 

  72. Silverio Ados S, Pereira RG, Lima AR, Paula FB, Rodrigues MR, Baldissera L Jr, et al. The effects of the decaffeination of coffee samples on platelet aggregation in hyperlipidemic rats. Plant Foods Hum Nutr. 2013;68(3):268–73.

    Article  PubMed  CAS  Google Scholar 

  73. Lopez-Garcia E, van Dam RM, Qi L, Hu FB. Coffee consumption and markers of inflammation and endothelial dysfunction in healthy and diabetic women. Am J Clin Nutr. 2006;84(4):888–93.

    Article  CAS  PubMed  Google Scholar 

  74. Arsenault BJ, Earnest CP, Despres JP, Blair SN, Church TS. Obesity, coffee consumption and CRP levels in postmenopausal overweight/obese women: importance of hormone replacement therapy use. Eur J Clin Nutr. 2009;63(12):1419–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  75. Maki T, Pham NM, Yoshida D, Yin G, Ohnaka K, Takayanagi R, et al. The relationship of coffee and green tea consumption with high-sensitivity C-reactive protein in Japanese men and women. Clin Chem Lab Med. 2010;48(6):849–54.

    Article  CAS  PubMed  Google Scholar 

  76. Suzuki A, Nomura T, Jokura H, Kitamura N, Saiki A, Fujii A. Chlorogenic acid-enriched green coffee bean extract affects arterial stiffness assessed by the cardio-ankle vascular index in healthy men: a pilot study. Int J Food Sci Nutr. 2019;70(7):901–8.

    Article  CAS  PubMed  Google Scholar 

  77. Li Kwok Cheong JD, Croft KD, Henry PD, Matthews V, Hodgson JM, Ward NC. Green coffee polyphenols do not attenuate features of the metabolic syndrome and improve endothelial function in mice fed a high fat diet. Arch Biochem Biophys. 2014;559:46–52.

  78. Priftis A, Panagiotou E-M, Lakis K, Plika C, Halabalaki M, Ntasi G, et al. Roasted and green coffee extracts show antioxidant and cytotoxic activity in myoblast and endothelial cell lines in a cell specific manner. Food Chem Toxicol. 2018;114:119–27.

    Article  CAS  PubMed  Google Scholar 

  79. Kajikawa M, Maruhashi T, Hidaka T, Nakano Y, Kurisu S, Matsumoto T, et al. Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension. Eur J Nutr. 2019;58(3):989–96.

    Article  CAS  PubMed  Google Scholar 

  80. Higashi Y. Coffee and Endothelial Function: A Coffee Paradox? Nutrients. 2019;11(9).

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Authors and Affiliations

  1. School of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Mehrnaz Morvaridi

  2. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Elham Rayyani & Malihe Jaafari

  3. School of medicine, Bam University of Medical Sciences, Bam, Iran

    Alireza Khiabani

  4. Student Research Committee, School of medicine, Bam University of Medical Sciences, Bam, Iran

    Mehran Rahimlou

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Contributions

MR designed the research; MM and ER performed the systematic search and study selection; MR and MJ extracted the data; MR and MM analyzed the data; MJ, ER and AKh wrote the manuscript; MR and AKh edited the manuscript and all authors read and approved the final version of the manuscript.

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Correspondence to Mehran Rahimlou.

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Morvaridi, M., Rayyani, E., Jaafari, M. et al. The effect of green coffee extract supplementation on cardio metabolic risk factors: a systematic review and meta-analysis of randomized controlled trials. J Diabetes Metab Disord 19, 645–660 (2020). https://doi.org/10.1007/s40200-020-00536-x

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